NLRP9

NLRP9
Identifiers
Aliases	NLRP9 , CLR19.1, NALP9, NOD6, PAN12, NLR family, pyrin domain containing 9, NLR family pyrin domain containing 9
External IDs	OMIM: 609663; MGI: 2675377; HomoloGene: 18530; GeneCards: NLRP9; OMA:NLRP9 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.42 Start 55,708,438 bp [1] End 55,738,402 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A3 Start 19,725,390 bp [2] End 19,807,231 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte gonad testicle muscle layer of sigmoid colon tibial arteries body of stomach prostate fundus right coronary artery body of uterus Top expressed in zygote secondary oocyte primary oocyte jejunum embryo embryo morula colon epithelium of small intestine ileum More reference expression data BioGPS n/a
Gene ontology Molecular function ATP binding nucleotide binding protein binding Cellular component cytoplasm inflammasome complex Biological process positive regulation of interleukin-18 production defense response to virus pyroptosis immune system process inflammatory response innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 338321 243874 Ensembl ENSG00000185792 ENSMUSG00000060508 UniProt Q7RTR0 Q66X22 RefSeq (mRNA) NM_176820 NM_194058 RefSeq (protein) NP_789790 NP_918947 Location (UCSC) Chr 19: 55.71 – 55.74 Mb Chr 7: 19.73 – 19.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

NLRP9, short for NOD-like receptor family pyrin domain containing 9, is an intracellular protein that is expressed in the ovaries, testes, oocytes, and preimplantation embryos of mammals that is likely involved in reproductive processes. ^{[5] [6] [7]} It is also known as NALP9, NOD6, PAN12, and CLR19.1, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.

References

1. GRCh38: Ensembl release 89: ENSG00000185792 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060508 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dalbiès-Tran R, Papillier P, Pennetier S, Uzbekova S, Monget P (August 2005). "Bovine mater-like NALP9 is an oocyte marker gene". Mol. Reprod. Dev. 71 (4): 414–21. doi:10.1002/mrd.20298. PMID   15892040. S2CID   33157680.
6. Ponsuksili S, Brunner RM, Goldammer T, et al. (March 2006). "Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos". Biol. Reprod. 74 (3): 577–84. doi:10.1095/biolreprod.105.045096. PMID   16339045. S2CID   2784688.
7. Tian X, Pascal G, Monget P (2009). "Evolution and functional divergence of NLRP genes in mammalian reproductive systems". BMC Evol. Biol. 9 (1) 202. Bibcode:2009BMCEE...9..202T. doi: 10.1186/1471-2148-9-202 . PMC   2735741 . PMID   19682372.

Further reading

• Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID   12766759. S2CID   8088987.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID   12563287. S2CID   31417018.