NMD3

NMD3
Identifiers
Aliases	NMD3 , CGI-07, NMD3 ribosome export adaptor
External IDs	OMIM: 611021 MGI: 2140103 HomoloGene: 6127 GeneCards: NMD3
Gene location (Human)
Chr.	Chromosome 3 (human)
End	161,253,532 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	69,663,706 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; germinal epithelium; ; parotid gland; ; secondary oocyte; ; amniotic fluid; ; parietal pleura; ; visceral pleura; ; tibia; ; lactiferous duct; ; islet of Langerhans;
	Top expressed in
	secondary oocyte; ; primitive streak; ; morula; ; Paneth cell; ; yolk sac; ; hair follicle; ; neural tube; ; otic placode; ; esophagus; ; ureter;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-macromolecule adaptor activity ; RNA binding ; ribosomal large subunit binding ;
Cellular component	nucleus ; membrane ; nucleolus ; cytoplasm ; nucleoplasm ;
Biological process	protein transport ; ribosomal large subunit export from nucleus ; positive regulation of RNA biosynthetic process ; positive regulation of protein localization to nucleolus ; positive regulation of protein binding ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	51068
	97112
	ENSG00000169251
	ENSMUSG00000027787
	Q96D46
	Q99L48
	NM_015938 ; NM_001320227
	NM_133787
	NP_001307156 ; NP_057022
	NP_598548
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

60S ribosomal export protein NMD3 is a protein that in humans is encoded by the NMD3 gene.^[5]^[6]^[7]

Interactions

NMD3 has been shown to interact with XPO1.^[8]

Related Research Articles

Ribosome biogenesis is the process of making ribosomes. In prokaryotes, this process takes place in the cytoplasm with the transcription of many ribosome gene operons. In eukaryotes, it takes place both in the cytoplasm and in the nucleolus. It involves the coordinated function of over 200 proteins in the synthesis and processing of the three prokaryotic or four eukaryotic rRNAs, as well as assembly of those rRNAs with the ribosomal proteins. Most of the ribosomal proteins fall into various energy-consuming enzyme families including ATP-dependent RNA helicases, AAA-ATPases, GTPases, and kinases. About 60% of a cell's energy is spent on ribosome production and maintenance.

Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.

60S ribosomal protein L7a is a protein that in humans is encoded by the RPL7A gene.

40S ribosomal protein S3 is a protein that in humans is encoded by the RPS3 gene.

40S ribosomal protein S4, X isoform is a protein that in humans is encoded by the RPS4X gene.

60S ribosomal protein L7 is a protein that in humans is encoded by the RPL7 gene.

60S ribosomal protein L4 is a protein that in humans is encoded by the RPL4 gene.

60S ribosomal protein L14 is a protein that in humans is encoded by the RPL14 gene.

60S ribosomal protein L18a is a protein that in humans is encoded by the RPL18A gene.

40S ribosomal protein S5 is a ribosomal subunit of the Eukaryotic ribosome (80S) complex. In humans it is encoded by the RPS5 gene.

60S ribosomal protein L13a is a protein that in humans is encoded by the RPL13A gene.

39S ribosomal protein L28, mitochondrial is a protein that in humans is encoded by the MRPL28 gene.

28S ribosomal protein S30, mitochondrial is a protein that in humans is encoded by the MRPS30 gene.

28S ribosomal protein S7, mitochondrial is a protein that in humans is encoded by the MRPS7 gene.

39S ribosomal protein L11, mitochondrial is a protein that in humans is encoded by the MRPL11 gene.

28S ribosomal protein S28, mitochondrial is a protein that in humans is encoded by the MRPS28 gene.

39S ribosomal protein L30, mitochondrial is a protein that in humans is encoded by the MRPL30 gene.

39S ribosomal protein L39, mitochondrial is a protein that in humans is encoded by the MRPL39 gene.

28S ribosomal protein S11, mitochondrial is a protein that in humans is encoded by the MRPS11 gene.

39S ribosomal protein L24, mitochondrial is a protein that in humans is encoded by the MRPL24 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169251 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027787 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876 . PMID 10810093.
↑ Trotta CR, Lund E, Kahan L, Johnson AW, Dahlberg JE (May 2003). "Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates". EMBO J. 22 (11): 2841–51. doi:10.1093/emboj/cdg249. PMC 156746 . PMID 12773398.
↑ "Entrez Gene: NMD3 NMD3 homolog (S. cerevisiae)".
↑ Thomas F, Kutay U (Jun 2003). "Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway". J. Cell Sci. 116 (Pt 12): 2409–19. doi: 10.1242/jcs.00464 . PMID 12724356.

NMD3

Contents

Interactions

Related Research Articles

References

Further reading