NOL8

NOL8
Identifiers
Aliases	NOL8 , C9orf34, NOP132, bA62C3.3, bA62C3.4, nucleolar protein 8
External IDs	MGI: 1918180 HomoloGene: 41210 GeneCards: NOL8
Gene location (Human)
Chr.	Chromosome 9 (human) [1]
End	92,325,636 bp [1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse) [2]
End	49,679,016 bp [2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• protein binding ; • nucleic acid binding ; • RNA binding ;
Cellular component	• nucleolus ; • Cell nucleus ;
Biological process	• rRNA processing ; • protein localization to nucleolus ;
	Sources:Amigo / QuickGO
Orthologs
	55035
	70930
	ENSG00000198000
	ENSMUSG00000021392
	Q76FK4
	Q3UHX0
	NM_001256394 ; NM_017948 ; NM_001330722
	NM_001081350 ; NM_001271397
	NP_001243323 ; NP_001317651 ; NP_060418 ; NP_001243323.1
	NP_001258326
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 26, 2019

Nucleolar protein 8 is a protein that in humans is encoded by the NOL8 gene.^[5]^[6]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Interactions

NOL8 has been shown to interact with RRAGA ^[7] and NIP7.^[7]

Ras-related GTP-binding protein A is a protein that in humans is encoded by the RRAGA gene.

60S ribosome subunit biogenesis protein NIP7 homolog is a protein that in humans is encoded by the NIP7 gene.

Related Research Articles

Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene.

Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein.

DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.

Zyxin is a protein that in humans is encoded by the ZYX gene.

Ran-binding protein 9 is a protein that in humans is encoded by the RANBP9 gene.

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative splicing.

Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.

Putative ribosomal RNA methyltransferase NOP2 is an enzyme that in humans is encoded by the NOP2 gene.

Nucleolar protein 56 is a protein that in humans is encoded by the NOP56 gene.

Nucleolar protein 3 is a protein that in humans is encoded by the NOL3 gene.

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene.

Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene.

Prostaglandin F2 receptor negative regulator is a protein that in humans is encoded by the PTGFRN gene. PTGFRN has also been designated as CD315.

Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.

Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene.

Ras-related GTP binding C, also known as RRAGC, is a protein which in humans is encoded by the RRAGC gene.

Ras-related GTP-binding protein B is a protein that in humans is encoded by the RRAGB gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198000 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021392 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241  . PMID 12477932.
↑ "Entrez Gene: NOL8 nucleolar protein 8".
1 2 Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". J. Biol. Chem. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". J. Biol. Chem. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.
Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". J. Biol. Chem. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.
Jinawath N, Furukawa Y, Nakamura Y (2004). "Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer". Cancer Sci. 95 (5): 430–5. doi:10.1111/j.1349-7006.2004.tb03227.x. PMID 15132771.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198000 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021392 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241  . PMID 12477932.

[entrez-6] "Entrez Gene: NOL8 nucleolar protein 8".

[pmid14660641-7] 1 2 Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". J. Biol. Chem. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.

NOL8

Contents

Interactions

Related Research Articles

References

Further reading