RRAGA

Last updated
RRAGA
Identifiers
Aliases RRAGA , FIP-1, FIP1, RAGA, Ras related GTP binding A
External IDs OMIM: 612194 MGI: 1915691 HomoloGene: 68522 GeneCards: RRAGA
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006570

NM_178376

RefSeq (protein)

NP_006561

NP_848463

Location (UCSC) Chr 9: 19.05 – 19.05 Mb Chr 4: 86.58 – 86.58 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related GTP-binding protein A is a protein that in humans is encoded by the RRAGA gene. [5] [6] [7]

Contents

Interactions

RRAGA has been shown to interact with NOL8 [8] and RRAGC. [9] [10]

Related Research Articles

RAP1A

Ras-related protein Rap-1A is a protein that in humans is encoded by the RAP1A gene.

RHEB

RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle.

RCC1

Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein.

RAC3

Ras-related C3 botulinum toxin substrate 3 (Rac3) is a G protein that in humans is encoded by the RAC3 gene. It is an important component of intracellular signalling pathways. Rac3 is a member of the Rac subfamily of the Rho family of small G proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.

ARHGAP1 Protein-coding gene in humans

Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARHGAP1 gene.

RALA

Ras-related protein Ral-A (RalA) is a protein that in humans is encoded by the RALA gene on chromosome 7. This protein is one of two paralogs of the Ral protein, the other being RalB, and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly cell division and transport, via signaling pathways. Its biological role thus implicates it in many cancers.

MTF1

Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.

RAB2A

Ras-related protein Rab-2A is a protein that in humans is encoded by the RAB2A gene.

RALB

Ras-related protein Ral-B (RalB) is a protein that in humans is encoded by the RALB gene on chromosome 2. This protein is one of two paralogs of the Ral protein, the other being RalA, and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly cell division and transport, via signaling pathways. Its biological role thus implicates it in many cancers.

RABAC1

RABAC1 is a gene that in humans encodes the protein Prenylated Rab acceptor 1, also called PRA1, PRAF1, or RABAC1. It is highly conserved in eukaryotes. The protein is localized to Golgi and late endosomes, where it plays a role in vesicular trafficking, lipid transport and cell migration.

RAB3B

Ras-related protein Rab-3B is a protein that in humans is encoded by the RAB3B gene.

PDE6D

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the PDE6D gene. PDE6D was originally identified as a fourth subunit of rod cell-specific cGMP phosphodiesterase (PDE). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport.

Rnd2

Rnd2 is a small signaling G protein, and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND2.

GALNAC4S-6ST

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene. It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.

NIP7

60S ribosome subunit biogenesis protein NIP7 homolog is a protein that in humans is encoded by the NIP7 gene.

NOL8

Nucleolar protein 8 is a protein that in humans is encoded by the NOL8 gene.

RIT2 Protein-coding gene in humans

GTP-binding protein Rit2 is a protein that in humans is encoded by the RIT2 gene.

RABL6

Rab-like protein 6 is a protein that in humans is encoded by the RABL6 gene.

RRAGC

Ras-related GTP binding C, also known as RRAGC, is a protein which in humans is encoded by the RRAGC gene.

RRAGB

Ras-related GTP-binding protein B is a protein that in humans is encoded by the RRAGB gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000155876 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070934 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Schürmann A, Brauers A, Massmann S, Becker W, Joost HG (Dec 1995). "Cloning of a novel family of mammalian GTP-binding proteins (raga d, RagBs, RagB1) with remote similarity to the Ras-related GTPases". The Journal of Biological Chemistry. 270 (48): 28982–8. doi: 10.1074/jbc.270.48.28982 . PMID   7499430.
  6. Li Y, Kang J, Horwitz MS (Feb 1997). "Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers". Journal of Virology. 71 (2): 1576–82. doi:10.1128/JVI.71.2.1576-1582.1997. PMC   191215 . PMID   8995684.
  7. "Entrez Gene: RRAGA Ras-related GTP binding A".
  8. Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". The Journal of Biological Chemistry. 279 (9): 8343–50. doi: 10.1074/jbc.M305935200 . PMID   14660641.
  9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
  10. Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi: 10.1074/jbc.M004389200 . PMID   11073942.

Further reading