RRAGC

RRAGC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LLU
Identifiers
Aliases	RRAGC , GTR2, RAGC, TIB929, Ras related GTP binding C
External IDs	OMIM: 608267 MGI: 1858751 HomoloGene: 39141 GeneCards: RRAGC
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p34.3 Start 38,838,198 bp [1] End 38,859,772 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D2.2 Start 123,811,239 bp [2] End 123,830,790 bp [2]
RNA expression pattern Bgee Top expressed in subcutaneous adipose tissue adipose tissue islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding GO:0001948 protein binding GO:0006184 GTPase activity magnesium ion binding GDP binding protein heterodimerization activity GTPase binding Cellular component cytoplasm cytosol intracellular membrane-bounded organelle lysosome nucleus Gtr1-Gtr2 GTPase complex Biological process regulation of TOR signaling small GTPase mediated signal transduction cellular response to amino acid starvation transcription, DNA-templated cellular protein localization cell growth RNA splicing apoptotic process regulation of TORC1 signaling response to amino acid regulation of autophagy regulation of macroautophagy positive regulation of TOR signaling cellular response to amino acid stimulus cellular response to starvation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64121	54170
Ensembl	ENSG00000116954	ENSMUSG00000028646
UniProt	Q9HB90	Q99K70
RefSeq (mRNA)	NM_022157 NM_001271851	NM_017475
RefSeq (protein)	NP_001258780 NP_071440	NP_059503
Location (UCSC)	Chr 1: 38.84 – 38.86 Mb	Chr 4: 123.81 – 123.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related GTP binding C, also known as RRAGC, is a protein which in humans is encoded by the RRAGC gene. ^{[5] [6]}

RRAGC is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways. ^[5]

Interactions

RRAGC has been shown to interact with RRAGA. ^{[6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000116954 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028646 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RRAGC Ras-related GTP binding C".
6. Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi: 10.1074/jbc.M004389200 . PMID   11073942.
7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading

• Horwitz MS (Jan 2001). "Adenovirus immunoregulatory genes and their cellular targets". Virology. 279 (1): 1–8. doi: 10.1006/viro.2000.0738 . PMID   11145883.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". The Journal of Biological Chemistry. 279 (9): 8343–50. doi: 10.1074/jbc.M305935200 . PMID   14660641.
• Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi: 10.1074/jbc.M004389200 . PMID   11073942.