NPTX1

NPTX1
Identifiers
Aliases	NPTX1 , NP1, neuronal pentraxin 1
External IDs	OMIM: 602367 MGI: 107811 HomoloGene: 1891 GeneCards: NPTX1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	80,477,843 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	119,438,579 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; middle temporal gyrus; ; frontal pole; ; parietal lobe; ; postcentral gyrus; ; superior frontal gyrus; ; Brodmann area 10; ; orbitofrontal cortex; ; occipital lobe; ; Brodmann area 46;
	Top expressed in
	cerebellar vermis; ; primary motor cortex; ; subiculum; ; habenula; ; prefrontal cortex; ; ventromedial nucleus; ; hippocampus proper; ; piriform cortex; ; superior frontal gyrus; ; Region I of hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding ;
Cellular component	transport vesicle ; cytoplasmic vesicle ; plasma membrane ; neuron projection ; glutamatergic synapse ;
Biological process	central nervous system development ; axonogenesis involved in innervation ; chemical synaptic transmission ; regulation of postsynaptic neurotransmitter receptor activity ;
	Sources:Amigo / QuickGO
Orthologs
	4884
	18164
	ENSG00000171246
	ENSMUSG00000025582
	Q15818
	Q62443
	NM_002522
	NM_008730
	NP_002513
	NP_032756
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Neuronal pentraxin-1 (NP1) is a protein that in humans is encoded by the NPTX1 gene.^[5]^[6]

Function

NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system.^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171246 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025582 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Omeis IA, Hsu YC, Perin MS (September 1996). "Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization". Genomics. 36 (3): 543–5. doi:10.1006/geno.1996.0503. PMID 8884281.
1 2 "Entrez Gene: neuronal pentraxin I".

Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2". J. Biol. Chem. 275 (23): 17786–92. doi: 10.1074/jbc.M002254200 . PMID 10748068.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Abad MA, Enguita M, DeGregorio-Rocasolano N, et al. (2006). "Neuronal pentraxin 1 contributes to the neuronal damage evoked by amyloid-beta and is overexpressed in dystrophic neurites in Alzheimer's brain". J. Neurosci. 26 (49): 12735–47. doi: 10.1523/JNEUROSCI.0575-06.2006 . PMC 6674827 . PMID 17151277.
Takahashi T, Strittmatter SM (2001). "Plexina1 autoinhibition by the plexin sema domain". Neuron. 29 (2): 429–39. doi: 10.1016/S0896-6273(01)00216-1 . PMID 11239433.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Poulsen TT, Pedersen N, Perin MS, et al. (2005). "Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin". Lung Cancer. 50 (3): 329–37. doi:10.1016/j.lungcan.2005.06.011. PMID 16115696.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171246 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025582 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8884281-5] Omeis IA, Hsu YC, Perin MS (September 1996). "Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization". Genomics. 36 (3): 543–5. doi:10.1006/geno.1996.0503. PMID 8884281.

[entrez-6] 1 2 "Entrez Gene: neuronal pentraxin I".

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NPTX1

Contents

Function

Related Research Articles

References

Further reading