NPTXR

NPTXR
Identifiers
Aliases	NPTXR , NPR, neuronal pentraxin receptor
External IDs	OMIM: 609474 MGI: 1920590 HomoloGene: 8620 GeneCards: NPTXR
Gene location (Human)
Chr.	Chromosome 22 (human)
End	38,844,028 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,688,967 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; frontal pole; ; Region I of hippocampus proper; ; cingulate gyrus; ; dorsolateral prefrontal cortex; ; amygdala; ; Brodmann area 9; ; orbitofrontal cortex; ; entorhinal cortex; ; Brodmann area 46;
	Top expressed in
	piriform cortex; ; subiculum; ; superior frontal gyrus; ; habenula; ; primary motor cortex; ; cingulate gyrus; ; medial dorsal nucleus; ; median eminence; ; dorsomedial hypothalamic nucleus; ; arcuate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding ;
Cellular component	membrane ; integral component of membrane ; plasma membrane ; cytoplasmic side of plasma membrane ; filopodium ; dendrite ; growth cone ; neuronal cell body ; glutamatergic synapse ;
Biological process	neuron projection development ; regulation of postsynaptic neurotransmitter receptor activity ;
	Sources:Amigo / QuickGO
Orthologs
	23467
	73340
	ENSG00000221890
	ENSMUSG00000022421
	O95502
	Q99J85
	NM_058178 ; NM_014293
	NM_030689
	NP_055108
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Neuronal pentraxin receptor is a protein that in humans is encoded by the NPTXR gene.^[5]^[6]

This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat protein pentraxin is thought to mediate neuronal uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for human and mouse, based on strong sequence conservation amongst these species.^[6]

Related Research Articles

Taipoxin is a potent myo- and neurotoxin that was isolated from the venom of the coastal taipan Oxyuranus scutellatus or also known as the common taipan. Taipoxin like many other pre-synaptic neurotoxins are phospholipase A₂ (PLA₂) toxins, which inhibit/complete block the release of the motor transmitter acetylcholine and lead to death by paralysis of the respiratory muscles (asphyxia). It is the most lethal neurotoxin isolated from any snake venom to date.

P2Y purinoceptor 13 is a protein that in humans is encoded by the P2RY13 gene.

MHC class II regulatory factor RFX1 is a protein that, in humans, is encoded by the RFX1 gene located on the short arm of chromosome 19.

Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.

Visinin-like protein 1 is a protein that in humans is encoded by the VSNL1 gene.

Hippocalcin-like protein 1 is a protein that in humans is encoded by the HPCAL1 gene.

Cytosolic phospholipase A2 gamma is an enzyme that in humans is encoded by the PLA2G4C gene.

DnaJ homolog subfamily C member 5, also known as cysteine string protein or CSP is a protein, that in humans encoded by the DNAJC5 gene. It was first described in 1990.

Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.

X-linked interleukin-1 receptor accessory protein-like 1 is a protein that in humans is encoded by the IL1RAPL1 gene. IL1RAPL1 is composed of 11 exons, about 1.37 Mb total.

Olfactory receptor 2F1 is a protein that in humans is encoded by the OR2F1 gene.

Olfactory receptor 5V1 is a protein that in humans is encoded by the OR5V1 gene.

Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene.

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.

Transcription factor RFX3 is a protein that in humans is encoded by the RFX3 gene.

Synaptotagmin-4 is a protein that in humans is encoded by the SYT4 gene.

Neuronal pentraxin-2 is a protein that in humans is encoded by the NPTX2 gene.

Reticulocalbin-2 is a protein that in humans is encoded by the RCN2 gene.

Protein orai-2 is a protein that in humans is encoded by the ORAI2 gene.

Neuronal pentraxin-1 (NP1) is a protein that in humans is encoded by the NPTX1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000221890 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022421 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Andersson KB, Florholmen G, Winer LH, Tonnessen T, Christensen G (Feb 2006). "Regulation of neuronal type genes in congestive heart failure rats". Acta Physiol (Oxf). 186 (1): 17–27. doi:10.1111/j.1748-1716.2005.01503.x. PMID 16497176. S2CID 46217094.
1 2 "Entrez Gene: NPTXR neuronal pentraxin receptor".

Poulsen TT, Pedersen N, Perin MS, et al. (2006). "Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin". Lung Cancer. 50 (3): 329–37. doi:10.1016/j.lungcan.2005.06.011. PMID 16115696.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2". J. Biol. Chem. 275 (23): 17786–92. doi: 10.1074/jbc.M002254200 . PMID 10748068.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
Dodds DC, Omeis IA, Cushman SJ, et al. (1997). "Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49". J. Biol. Chem. 272 (34): 21488–94. doi: 10.1074/jbc.272.34.21488 . PMID 9261167.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000221890 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022421 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16497176-5] Andersson KB, Florholmen G, Winer LH, Tonnessen T, Christensen G (Feb 2006). "Regulation of neuronal type genes in congestive heart failure rats". Acta Physiol (Oxf). 186 (1): 17–27. doi:10.1111/j.1748-1716.2005.01503.x. PMID 16497176. S2CID 46217094.

[entrez-6] 1 2 "Entrez Gene: NPTXR neuronal pentraxin receptor".

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NPTXR

Contents

See also

Related Research Articles

References

Further reading