NRD1

NRDC
Identifiers
Aliases	NRDC , hNRD1, hNRD2, NRD1, nardilysin convertase, nardilysin
External IDs	OMIM: 602651 MGI: 1201386 HomoloGene: 68260 GeneCards: NRDC
Gene location (Human)
Chr.	Chromosome 1 (human)
End	51,878,805 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	108,918,974 bp
RNA expression pattern
	Top expressed in
	quadriceps femoris muscle; ; testicle; ; gastrocnemius muscle; ; anterior pituitary; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity ; GO:0001948 protein binding ; catalytic activity ; metallopeptidase activity ; hydrolase activity ; metal ion binding ; epidermal growth factor binding ; metalloendopeptidase activity ;
Cellular component	cell surface ; cytosol ; mitochondrion ;
Biological process	positive regulation of membrane protein ectodomain proteolysis ; cell population proliferation ; neuromuscular junction development ; cell migration ; regulation of endopeptidase activity ; proteolysis ; negative regulation of cold-induced thermogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	4898
	230598
	ENSG00000078618
	ENSMUSG00000053510
	O43847
	Q8BHG1
	NM_001101662 ; NM_001242361 ; NM_002525
	NM_146150 ; NM_001346554 ; NM_001347169
	NP_001095132 ; NP_001229290 ; NP_002516
	NP_001333483 ; NP_001334098 ; NP_666262
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 09, 2022

Nardilysin is a protein that in humans is encoded by the NRD1 gene.^[5]^[6]^[7]

Interactions

NRD1 has been shown to interact with Heparin-binding EGF-like growth factor.^[8]

Related Research Articles

Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has 53 amino acid residues and three intramolecular disulfide bonds.

FGF2, also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins, themselves a family of closely related molecules. Fibroblast growth factor protein was first purified in 1975; soon thereafter three variants were isolated: 'basic FGF' (FGF2); Heparin-binding growth factor-2; and Endothelial cell growth factor-2. Gene sequencing revealed that this group is the same FGF2 protein and is a member of a family of FGF proteins.

Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTN gene. Pleiotrophin is an 18-kDa growth factor that has a high affinity for heparin. It is structurally related to midkine and retinoic acid induced heparin-binding protein.

Midkine, also known as neurite growth-promoting factor 2 (NEGF2), is a protein that in humans is encoded by the MDK gene.

Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene.

Epiregulin (EPR) is a protein that in humans is encoded by the EREG gene.

BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.

Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene.

Syndecan-3 is a protein that in humans is encoded by the SDC3 gene.

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene.

Insulin-like growth factor-binding protein 7 is a protein that in humans is encoded by the IGFBP7 gene. The major function of the protein is the regulation of availability of insulin-like growth factors (IGFs) in tissue as well as in modulating IGF binding to its receptors. IGFBP7 binds to IGF with high affinity. It also stimulates cell adhesion. The protein is implicated in some cancers.

Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.

Hyaluronan-binding protein 2 also known as factor VII activating protease (FSAP) is a protein that in humans is encoded by the HABP2 gene.

Latent-transforming growth factor beta-binding protein 1 is a protein that in humans is encoded by the LTBP1 gene.

Proprotein convertase subtilisin/kexin type 7 is an enzyme that in humans is encoded by the PCSK7 gene.

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.

Latent-transforming growth factor beta-binding protein 3 is a protein that in humans is encoded by the LTBP3 gene.

CAMP responsive element binding protein-like 1, also known as CREBL1, is a protein which in humans is encoded by the CREBL1 gene.

Nucleoside diphosphate-linked moiety X motif 6 is a protein that in humans is encoded by the NUDT6 gene.

Nardilysin is an enzyme. This enzyme catalyses the following chemical reaction

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000078618 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053510 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hospital V, Prat A, Joulie C, Cherif D, Day R, Cohen P (May 1998). "Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family". Biochem J. 327 (3): 773–9. doi:10.1042/bj3270773. PMC 1218856 . PMID 9581555.
↑ Fumagalli P, Accarino M, Egeo A, Scartezzini P, Rappazzo G, Pizzuti A, Avvantaggiato V, Simeone A, Arrigo G, Zuffardi O, Ottolenghi S, Taramelli R (Apr 1998). "Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues". Genomics. 47 (2): 238–45. doi:10.1006/geno.1997.5078. PMID 9479496.
↑ "Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase)".
↑ Nishi, E; Prat A; Hospital V; Elenius K; Klagsbrun M (Jul 2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. England. 20 (13): 3342–50. doi:10.1093/emboj/20.13.3342. ISSN 0261-4189. PMC 125525 . PMID 11432822.

Seidah NG, Prat A (2003). "Precursor convertases in the secretory pathway, cytosol and extracellular milieu". Essays Biochem. 38: 79–94. doi:10.1042/bse0380079. PMID 12463163.
Hospital V, Prat A (2005). "Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation". Protein Pept. Lett. 11 (5): 501–8. doi:10.2174/0929866043406508. PMID 15544571.
Winter AG, Pierotti AR (2001). "Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines". Biochem. J. 351 (3): 755–64. doi:10.1042/0264-6021:3510755. PMC 1221416 . PMID 11042131.
Nishi E, Prat A, Hospital V, et al. (2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. 20 (13): 3342–50. doi:10.1093/emboj/20.13.3342. PMC 125525 . PMID 11432822.
Ma Z, Csuhai E, Chow KM, Hersh LB (2001). "Expression of the acidic stretch of nardilysin as a functional binding domain". Biochemistry. 40 (31): 9447–52. doi:10.1021/bi010538x. PMID 11478915.
Hospital V, Nishi E, Klagsbrun M, et al. (2003). "The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF)". Biochem. J. 367 (Pt 1): 229–38. doi:10.1042/BJ20020822. PMC 1222870 . PMID 12095415.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Chow KM, Oakley O, Goodman J, et al. (2003). "Nardilysin cleaves peptides at monobasic sites". Biochemistry. 42 (7): 2239–44. doi:10.1021/bi027178d. PMID 12590613.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.
Nishi E, Hiraoka Y, Yoshida K, et al. (2006). "Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme". J. Biol. Chem. 281 (41): 31164–72. doi: 10.1074/jbc.M601316200 . PMID 16923819.
Bernstein HG, Stricker R, Dobrowolny H, et al. (2007). "Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons". Neuroscience. 146 (4): 1513–23. doi:10.1016/j.neuroscience.2007.02.057. PMID 17442499. S2CID 8060302.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000078618 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053510 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9581555-5] Hospital V, Prat A, Joulie C, Cherif D, Day R, Cohen P (May 1998). "Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family". Biochem J. 327 (3): 773–9. doi:10.1042/bj3270773. PMC 1218856 . PMID 9581555.

[pmid9479496-6] Fumagalli P, Accarino M, Egeo A, Scartezzini P, Rappazzo G, Pizzuti A, Avvantaggiato V, Simeone A, Arrigo G, Zuffardi O, Ottolenghi S, Taramelli R (Apr 1998). "Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues". Genomics. 47 (2): 238–45. doi:10.1006/geno.1997.5078. PMID 9479496.

[entrez-7] "Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase)".

[pmid11432822-8] Nishi, E; Prat A; Hospital V; Elenius K; Klagsbrun M (Jul 2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. England. 20 (13): 3342–50. doi:10.1093/emboj/20.13.3342. ISSN 0261-4189. PMC 125525 . PMID 11432822.

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NRD1

Contents

Interactions

Related Research Articles

References

Further reading