NRD1

NRDC
Identifiers
Aliases	NRDC , hNRD1, hNRD2, NRD1, nardilysin convertase, nardilysin
External IDs	OMIM: 602651; MGI: 1201386; HomoloGene: 68260; GeneCards: NRDC; OMA:NRDC - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p32.3 Start 51,789,191 bp [1] End 51,878,805 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 C7 Start 108,857,852 bp [2] End 108,918,974 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glutes right testis left testis muscle of thigh triceps brachii muscle gastrocnemius muscle anterior pituitary sperm Skeletal muscle tissue of biceps brachii thoracic diaphragm Top expressed in seminiferous tubule tail of embryo genital tubercle granulocyte spermatid plantaris muscle neural layer of retina muscle of thigh extensor digitorum longus muscle lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity protein binding catalytic activity metallopeptidase activity hydrolase activity metal ion binding epidermal growth factor binding metalloendopeptidase activity Cellular component cell surface cytosol mitochondrion Biological process positive regulation of membrane protein ectodomain proteolysis cell population proliferation neuromuscular junction development cell migration regulation of endopeptidase activity proteolysis negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4898 230598 Ensembl ENSG00000078618 ENSMUSG00000053510 UniProt O43847 Q8BHG1 RefSeq (mRNA) NM_001101662 NM_001242361 NM_002525 NM_146150 NM_001346554 NM_001347169 RefSeq (protein) NP_001095132 NP_001229290 NP_002516 NP_001333483 NP_001334098 NP_666262 Location (UCSC) Chr 1: 51.79 – 51.88 Mb Chr 4: 108.86 – 108.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nardilysin is a protein that in humans is encoded by the NRD1 gene. ^{[5] [6] [7]}

Interactions

NRD1 has been shown to interact with Heparin-binding EGF-like growth factor. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000078618 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053510 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hospital V, Prat A, Joulie C, Cherif D, Day R, Cohen P (May 1998). "Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family". Biochem J. 327 (3): 773–9. doi:10.1042/bj3270773. PMC   1218856 . PMID   9581555.
6. Fumagalli P, Accarino M, Egeo A, Scartezzini P, Rappazzo G, Pizzuti A, Avvantaggiato V, Simeone A, Arrigo G, Zuffardi O, Ottolenghi S, Taramelli R (Apr 1998). "Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues". Genomics. 47 (2): 238–45. doi:10.1006/geno.1997.5078. PMID   9479496.
7. "Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase)".
8. Nishi, E; Prat A; Hospital V; Elenius K; Klagsbrun M (Jul 2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. 20 (13). England: 3342–50. doi:10.1093/emboj/20.13.3342. ISSN   0261-4189. PMC   125525 . PMID   11432822.

Further reading

• Seidah NG, Prat A (2003). "Precursor convertases in the secretory pathway, cytosol and extracellular milieu". Essays Biochem. 38: 79–94. doi:10.1042/bse0380079. PMID   12463163.
• Hospital V, Prat A (2005). "Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation". Protein Pept. Lett. 11 (5): 501–8. doi:10.2174/0929866043406508. PMID   15544571.
• Winter AG, Pierotti AR (2001). "Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines". Biochem. J. 351 (3): 755–64. doi:10.1042/0264-6021:3510755. PMC   1221416 . PMID   11042131.
• Nishi E, Prat A, Hospital V, et al. (2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. 20 (13): 3342–50. doi:10.1093/emboj/20.13.3342. PMC   125525 . PMID   11432822.
• Ma Z, Csuhai E, Chow KM, Hersh LB (2001). "Expression of the acidic stretch of nardilysin as a functional binding domain". Biochemistry. 40 (31): 9447–52. doi:10.1021/bi010538x. PMID   11478915.
• Hospital V, Nishi E, Klagsbrun M, et al. (2003). "The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF)". Biochem. J. 367 (Pt 1): 229–38. doi:10.1042/BJ20020822. PMC   1222870 . PMID   12095415.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Chow KM, Oakley O, Goodman J, et al. (2003). "Nardilysin cleaves peptides at monobasic sites". Biochemistry. 42 (7): 2239–44. doi:10.1021/bi027178d. PMID   12590613.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Nishi E, Hiraoka Y, Yoshida K, et al. (2006). "Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme". J. Biol. Chem. 281 (41): 31164–72. doi: 10.1074/jbc.M601316200 . PMID   16923819.
• Bernstein HG, Stricker R, Dobrowolny H, et al. (2007). "Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons". Neuroscience. 146 (4): 1513–23. doi:10.1016/j.neuroscience.2007.02.057. PMID   17442499. S2CID   8060302.