NTN5

NTN5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4URT
Identifiers
Aliases	NTN5 , netrin 5
External IDs	MGI: 2685330; HomoloGene: 17106; GeneCards: NTN5; OMA:NTN5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.33 Start 48,661,407 bp [1] End 48,673,081 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B3 Start 45,333,446 bp [2] End 45,343,980 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube pituitary gland anterior pituitary left ovary right ovary cerebellar hemisphere right hemisphere of cerebellum left uterine tube granulocyte canal of the cervix Top expressed in gastrula dentate gyrus of hippocampal formation granule cell primary visual cortex seminiferous tubule superior frontal gyrus cervix embryo hippocampus proper stria vascularis nerve More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 126147 243967 Ensembl ENSG00000142233 ENSMUSG00000070564 UniProt Q8WTR8 Q3UQ22 RefSeq (mRNA) NM_145807 NM_001033356 NM_001289692 NM_001289693 NM_001358870 RefSeq (protein) NP_665806 NP_001028528 NP_001276621 NP_001276622 NP_001345799 Location (UCSC) Chr 19: 48.66 – 48.67 Mb Chr 7: 45.33 – 45.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Netrin-5 (NTN5), also known as netrin-1-like protein, is a protein that in humans is encoded by the NTN5 gene. ^[5] Netrin-5 is included in the family of secreted laminin-related proteins.

Function

Netrin-5 functions are not fully clarified. However, it is believed to:

• Plays an important role in neurogenesis by controlling the development of dendrites and acting as a guide for axons. ^{[6] [7]}
• Regulates cell migration in the brain during embryonic development. ^[8]
• Prevents motor neuron cell body migration out of the neural tube. ^[8]

Clinical significance

A recent genome-wide association study (GWAS) has found that genetic variations in HAVCR2 are associated with late-onset sporadic Alzheimer's disease (LOAD). However, it's unknown how netrin-5 mutation contributes to disease. ^[9]

Considering the role of NTN5 in cell migration, it is very possible that netrin-5 has an important role in human carcinogenesis, although currently no tumor type with NTN5 alterations has been identified. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000142233 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070564 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "NTN5 netrin 5 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-12-11.
6. Yamagishi S, Yamada K, Sawada M, Nakano S, Mori N, Sawamoto K, et al. (2015). "Netrin-5 is highly expressed in neurogenic regions of the adult brain". Frontiers in Cellular Neuroscience. 9: 146. doi: 10.3389/fncel.2015.00146 . PMC   4403520 . PMID   25941474.
7. Ikegaya S, Iga Y, Mikawa S, Zhou L, Abe M, Sakimura K, et al. (2020). "Decreased Proliferation in the Neurogenic Niche, Disorganized Neuroblast Migration, and Increased Oligodendrogenesis in Adult Netrin-5-Deficient Mice". Frontiers in Neuroscience. 14 570974. doi: 10.3389/fnins.2020.570974 . PMC   7726356 . PMID   33324143.
8. Gaudet P, Livstone MS, Lewis SE, Thomas PD (September 2011). "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium". Briefings in Bioinformatics. 12 (5): 449–462. doi:10.1093/bib/bbr042. PMC   3178059 . PMID   21873635.
9. Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, et al. (September 2021). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics. 53 (9): 1276–1282. doi:10.1038/s41588-021-00921-z. hdl: 1871.1/61f01aa9-6dc7-4213-be2a-d3fe622db488 . PMC   10243600 . PMID   34493870. S2CID   237442349.
10. Bruikman CS, Zhang H, Kemper AM, van Gils JM (2019-02-24). "Netrin Family: Role for Protein Isoforms in Cancer". Journal of Nucleic Acids. 2019 3947123. doi: 10.1155/2019/3947123 . PMC   6408995 . PMID   30923634.