NUB1

Last updated
NUB1
Protein NUB1 PDB 1wju.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NUB1 , BS4, NUB1L, NYREN18, negative regulator of ubiquitin-like proteins 1, negative regulator of ubiquitin like proteins 1
External IDs OMIM: 607981; MGI: 1889001; HomoloGene: 41108; GeneCards: NUB1; OMA:NUB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016736
NM_001305264

RefSeq (protein)

NP_001230280
NP_057202
NP_001350458

NP_001292193
NP_058016

Location (UCSC) Chr 7: 151.34 – 151.38 Mb Chr 5: 24.89 – 24.92 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

NEDD8 ultimate buster 1 is a protein that in humans is encoded by the NUB1 gene. [5] [6] [7]

Contents

Function

NUB1 interacts with and negatively regulates NEDD8 (MIM 603171), a ubiquitin-like protein that covalently conjugates to cullin (see MIM 603134) family members.[supplied by OMIM] [7]

Interactions

NUB1 has been shown to interact with NEDD8, [8] [9] UBD [8] and AIPL1. [10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000013374 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028954 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–64. doi: 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 . PMID   10508479.
  6. Kito K, Yeh ET, Kamitani T (Jun 2001). "NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression". The Journal of Biological Chemistry. 276 (23): 20603–9. doi: 10.1074/jbc.M100920200 . PMID   11259415.
  7. 1 2 "Entrez Gene: NUB1 negative regulator of ubiquitin-like proteins 1".
  8. 1 2 Hipp MS, Raasi S, Groettrup M, Schmidtke G (Apr 2004). "NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation". The Journal of Biological Chemistry. 279 (16): 16503–10. doi: 10.1074/jbc.M310114200 . PMID   14757770.
  9. Kamitani T, Kito K, Fukuda-Kamitani T, Yeh ET (Dec 2001). "Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1". The Journal of Biological Chemistry. 276 (49): 46655–60. doi: 10.1074/jbc.M108636200 . PMID   11585840.
  10. Akey DT, Zhu X, Dyer M, Li A, Sorensen A, Blackshaw S, Fukuda-Kamitani T, Daiger SP, Craft CM, Kamitani T, Sohocki MM (Oct 2002). "The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1". Human Molecular Genetics. 11 (22): 2723–33. doi:10.1093/hmg/11.22.2723. PMC   2585502 . PMID   12374762.

Further reading