NUMBL

NUMBL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3F0W
Identifiers
Aliases	NUMBL , CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23, NUMB like, endocytic adaptor protein, NUMB like endocytic adaptor protein
External IDs	OMIM: 604018 MGI: 894702 HomoloGene: 68413 GeneCards: NUMBL
Gene location (Human)
Chr.	Chromosome 19 (human)
End	40,690,972 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	26,981,569 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; cardia; ; trigeminal ganglion; ; nipple; ; trachea; ; endothelial cell; ; pylorus; ; ventral tegmental area; ; spinal ganglia; ; medulla oblongata;
	Top expressed in
	superior frontal gyrus; ; lip; ; piriform cortex; ; hippocampus proper; ; ganglionic eminence; ; cerebellar cortex; ; subiculum; ; prefrontal cortex; ; molar; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ;
Biological process	multicellular organism development ; positive regulation of neurogenesis ; neuroblast proliferation ; forebrain development ; protein metabolic process ; adherens junction organization ; neuroblast division in subventricular zone ; axonogenesis ; lateral ventricle development ; nervous system development ; cytokine-mediated signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	9253
	18223
	ENSG00000105245
	ENSMUSG00000063160
	Q9Y6R0
	O08919
	NM_001289979 ; NM_001289980 ; NM_004756
	NM_010950
	NP_001276908 ; NP_001276909 ; NP_004747
	NP_035080
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 07, 2024

Numb-like protein is a protein that in humans is encoded by the NUMBL gene.^[5]^[6]^[7]

Interactions

NUMBL has been shown to interact with MAP3K7IP2.^[8]

Related Research Articles

Protein numb homolog is a protein that in humans is encoded by the NUMB gene. The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105245 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063160 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. S2CID 25999127.
↑ Salcini AE, Confalonieri S, Doria M, Santolini E, Tassi E, Minenkova O, Cesareni G, Pelicci PG, Di Fiore PP (Oct 1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC 275390 . PMID 9303539.
↑ "Entrez Gene: NUMBL numb homolog (Drosophila)-like".
↑ Ma Q, Zhou Li, Shi Huili, Huo Keke (Jun 2008). "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation". Cell. Signal. 20 (6). England: 1044–51. doi:10.1016/j.cellsig.2008.01.015. ISSN 0898-6568. PMID 18299187.

Wong WT, Schumacher C, Salcini AE, et al. (1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9530–4. Bibcode:1995PNAS...92.9530W. doi: 10.1073/pnas.92.21.9530 . PMC 40835 . PMID 7568168.
Zhong W, Feder JN, Jiang MM, et al. (1996). "Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis". Neuron. 17 (1): 43–53. doi: 10.1016/S0896-6273(00)80279-2 . PMID 8755477.
Zhong W, Jiang MM, Weinmaster G, et al. (1997). "Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis". Development. 124 (10): 1887–97. doi:10.1242/dev.124.10.1887. PMID 9169836.
Roncarati R, Sestan N, Scheinfeld MH, et al. (2002). "The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 7102–7. Bibcode:2002PNAS...99.7102R. doi: 10.1073/pnas.102192599 . PMC 124535 . PMID 12011466.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID 15324660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105245 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063160 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9225980-5] Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. S2CID 25999127.

[pmid9303539-6] Salcini AE, Confalonieri S, Doria M, Santolini E, Tassi E, Minenkova O, Cesareni G, Pelicci PG, Di Fiore PP (Oct 1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC 275390 . PMID 9303539.

[entrez-7] "Entrez Gene: NUMBL numb homolog (Drosophila)-like".

[pmid18299187-8] Ma Q, Zhou Li, Shi Huili, Huo Keke (Jun 2008). "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation". Cell. Signal. 20 (6). England: 1044–51. doi:10.1016/j.cellsig.2008.01.015. ISSN 0898-6568. PMID 18299187.

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NUMBL

Contents

Interactions

Related Research Articles

References

Further reading