NUMBL

NUMBL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3F0W
Identifiers
Aliases	NUMBL , CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23, NUMB like, endocytic adaptor protein, NUMB like endocytic adaptor protein
External IDs	OMIM: 604018; MGI: 894702; HomoloGene: 68413; GeneCards: NUMBL; OMA:NUMBL - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.2 Start 40,665,905 bp [1] End 40,690,972 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A3 Start 26,957,858 bp [2] End 26,981,569 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell buccal mucosa cell cardia trigeminal ganglion nipple trachea endothelial cell pylorus ventral tegmental area spinal ganglia Top expressed in dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus ventricular zone lip piriform cortex hippocampus proper ganglionic eminence cerebellar cortex subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm Biological process multicellular organism development positive regulation of neurogenesis neuroblast proliferation forebrain development protein metabolic process adherens junction organization neuroblast division in subventricular zone axonogenesis lateral ventricle development nervous system development cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9253 18223 Ensembl ENSG00000105245 ENSMUSG00000063160 UniProt Q9Y6R0 O08919 RefSeq (mRNA) NM_001289979 NM_001289980 NM_004756 NM_010950 RefSeq (protein) NP_001276908 NP_001276909 NP_004747 NP_035080 Location (UCSC) Chr 19: 40.67 – 40.69 Mb Chr 7: 26.96 – 26.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Numb-like protein is a protein that in humans is encoded by the NUMBL gene. ^{[5] [6] [7]}

Interactions

NUMBL has been shown to interact with MAP3K7IP2. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000105245 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063160 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID   9225980. S2CID   25999127.
6. Salcini AE, Confalonieri S, Doria M, Santolini E, Tassi E, Minenkova O, Cesareni G, Pelicci PG, Di Fiore PP (Oct 1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC   275390 . PMID   9303539.
7. "Entrez Gene: NUMBL numb homolog (Drosophila)-like".
8. Ma Q, Zhou Li, Shi Huili, Huo Keke (Jun 2008). "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation". Cell. Signal. 20 (6). England: 1044–51. doi:10.1016/j.cellsig.2008.01.015. ISSN   0898-6568. PMID   18299187.

Further reading

• Wong WT, Schumacher C, Salcini AE, et al. (1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9530–4. Bibcode:1995PNAS...92.9530W. doi: 10.1073/pnas.92.21.9530 . PMC   40835 . PMID   7568168.
• Zhong W, Feder JN, Jiang MM, et al. (1996). "Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis". Neuron. 17 (1): 43–53. doi: 10.1016/S0896-6273(00)80279-2 . PMID   8755477.
• Zhong W, Jiang MM, Weinmaster G, et al. (1997). "Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis". Development. 124 (10): 1887–97. doi:10.1242/dev.124.10.1887. PMID   9169836.
• Roncarati R, Sestan N, Scheinfeld MH, et al. (2002). "The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 7102–7. Bibcode:2002PNAS...99.7102R. doi: 10.1073/pnas.102192599 . PMC   124535 . PMID   12011466.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.