NUPL2

NUP42
Identifiers
Aliases	NUP42 , CG1, NLP-1, NLP_1, hCG1, nucleoporin like 2, NUPL2, nucleoporin 42
External IDs	MGI: 2387631; HomoloGene: 40573; GeneCards: NUP42; OMA:NUP42 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p15.3 Start 23,181,841 bp [1] End 23,201,011 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 A3 Start 24,369,961 bp [2] End 24,389,011 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere monocyte right hemisphere of cerebellum rectum right uterine tube right testis left testis right adrenal cortex gonad spleen Top expressed in spermatid seminiferous tubule spermatocyte interventricular septum internal carotid artery external carotid artery embryo muscle of thigh embryo zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nuclear export signal receptor activity metal ion binding protein binding RNA binding Cellular component nuclear membrane nuclear envelope membrane nuclear pore nucleoplasm nucleus cytosol host cell Biological process mRNA transport viral transcription protein sumoylation mitotic nuclear membrane disassembly protein export from nucleus regulation of cellular response to heat protein transport viral process intracellular transport of virus mRNA export from nucleus tRNA export from nucleus regulation of gene silencing by miRNA regulation of glycolytic process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11097 231042 Ensembl ENSG00000136243 ENSMUSG00000048439 UniProt O15504 Q8CIC2 RefSeq (mRNA) NM_007342 NM_001370443 NM_001370444 NM_001370445 NM_001370446 NM_153092 NM_001346582 RefSeq (protein) NP_031368 NP_001357372 NP_001357373 NP_001357374 NP_001357375 NP_001333511 NP_694732 Location (UCSC) Chr 7: 23.18 – 23.2 Mb Chr 5: 24.37 – 24.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nucleoporin-like 2 is a protein that in humans is encoded by the NUPL2 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000136243 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048439 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Farjot G, Sergeant A, Mikaelian I (Jul 1999). "A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1". J Biol Chem. 274 (24): 17309–17317. doi: 10.1074/jbc.274.24.17309 . PMID   10358091.
6. Van Laer L, Van Camp G, van Zuijlen D, Green ED, Verstreken M, Schatteman I, Van de Heyning P, Balemans W, Coucke P, Greinwald JH, Smith RJ, Huizing E, Willems P (Mar 1998). "Refined mapping of a gene for autosomal dominant progressive sensorineural hearing loss (DFNA5) to a 2-cM region, and exclusion of a candidate gene that is expressed in the cochlea". Eur J Hum Genet. 5 (6): 397–405. PMID   9450185.
7. "Entrez Gene: NUPL2 nucleoporin like 2".

Further reading

• Fouchier RA, Meyer BE, Simon JH, et al. (1998). "Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex". J. Virol. 72 (7): 6004–13. doi:10.1128/JVI.72.7.6004-6013.1998. PMC   110405 . PMID   9621063.
• Katahira J, Strässer K, Podtelejnikov A, et al. (1999). "The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human". EMBO J. 18 (9): 2593–2609. doi:10.1093/emboj/18.9.2593. PMC   1171339 . PMID   10228171.
• Strahm Y, Fahrenkrog B, Zenklusen D, et al. (1999). "The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p". EMBO J. 18 (20): 5761–5777. doi:10.1093/emboj/18.20.5761. PMC   1171643 . PMID   10610322.
• de Noronha CM, Sherman MP, Lin HW, et al. (2001). "Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr". Science. 294 (5544): 1105–1108. Bibcode:2001Sci...294.1105D. doi:10.1126/science.1063957. PMID   11691994. S2CID   29771914.
• Le Rouzic E, Mousnier A, Rustum C, et al. (2003). "Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1". J. Biol. Chem. 277 (47): 45091–45098. doi: 10.1074/jbc.M207439200 . PMID   12228227.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Sasaki M, Takeda E, Takano K, et al. (2005). "Molecular cloning and functional characterization of mouse Nxf family gene products". Genomics. 85 (5): 641–653. doi:10.1016/j.ygeno.2005.01.003. PMID   15820316.
• Kendirgi F, Rexer DJ, Alcázar-Román AR, et al. (2006). "Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA". Mol. Biol. Cell. 16 (9): 4304–4315. doi:10.1091/mbc.E04-11-0998. PMC   1196339 . PMID   16000379.
• Deniaud A, Brenner C, Kroemer G (2005). "Mitochondrial membrane permeabilization by HIV-1 Vpr". Mitochondrion. 4 (2–3): 223–233. doi:10.1016/j.mito.2004.06.012. PMID   16120388.