NUPR1

NUPR1
Identifiers
Aliases	NUPR1 , COM1, P8, nuclear protein 1, transcriptional regulator
External IDs	OMIM: 614812 MGI: 1891834 HomoloGene: 8229 GeneCards: NUPR1
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p11.2 Start 28,532,708 bp [1] End 28,539,008 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F3 Start 126,222,421 bp [2] End 126,230,033 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left lobe of thyroid gland right lobe of thyroid gland body of pancreas gastric mucosa skin of abdomen right lung prostate right lobe of liver left coronary artery subcutaneous adipose tissue Top expressed in submandibular gland lacrimal gland calvaria crypt of lieberkuhn of small intestine ascending aorta epithelium of stomach parotid gland pyloric antrum aortic valve right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chromatin binding DNA binding protein binding transcription coactivator activity acetyltransferase activator activity Cellular component nucleus cytosol protein-DNA complex cytoplasm perinuclear region of cytoplasm Biological process skeletal muscle cell differentiation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of cell cycle male gonad development regulation of transcription, DNA-templated acute inflammatory response negative regulation of fibroblast proliferation regulation of female gonad development response to toxic substance transcription, DNA-templated protein acetylation positive regulation of protein modification process positive regulation of apoptotic process regulation of transcription by RNA polymerase II cell population proliferation protein-containing complex assembly negative regulation of cell population proliferation positive regulation of catalytic activity positive regulation of proteasomal protein catabolic process positive regulation of nucleic acid-templated transcription regulation of autophagy negative regulation of autophagy negative regulation of cardiac muscle cell apoptotic process negative regulation of apoptotic process negative regulation of DNA-binding transcription factor activity positive regulation of neuron apoptotic process negative regulation of glycolytic process negative regulation of epithelial cell proliferation negative regulation of programmed necrotic cell death positive regulation of neuroinflammatory response negative regulation of autophagosome assembly positive regulation of oxidative phosphorylation negative regulation of epithelial cell apoptotic process negative regulation of type B pancreatic cell proliferation regulation of response to endoplasmic reticulum stress positive regulation of intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26471 56312 Ensembl ENSG00000176046 ENSMUSG00000030717 UniProt O60356 Q9WTK0 RefSeq (mRNA) NM_012385 NM_001042483 NM_019738 RefSeq (protein) NP_001035948 NP_036517 NP_062712 Location (UCSC) Chr 16: 28.53 – 28.54 Mb Chr 7: 126.22 – 126.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear protein 1 is a protein that in humans is encoded by the NUPR1 gene. ^{[5] [6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000176046 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030717 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mallo GV, Fiedler F, Calvo EL, Ortiz EM, Vasseur S, Keim V, Morisset J, Iovanna JL (Jan 1998). "Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth". J Biol Chem. 272 (51): 32360–9. doi: 10.1074/jbc.272.51.32360 . PMID   9405444.
6. Ree AH, Tvermyr M, Engebraaten O, Rooman M, Rosok O, Hovig E, Meza-Zepeda LA, Bruland OS, Fodstad O (Oct 1999). "Expression of a novel factor in human breast cancer cells with metastatic potential". Cancer Res. 59 (18): 4675–80. PMID   10493524.
7. Vasseur S, Vidal Mallo G, Fiedler F, Bodeker H, Canepa E, Moreno S, Iovanna JL (Apr 1999). "Cloning and expression of the human p8, a nuclear protein with mitogenic activity". Eur J Biochem. 259 (3): 670–5. doi: 10.1046/j.1432-1327.1999.00092.x . PMID   10092851.
8. "Entrez Gene: NUPR1 nuclear protein 1".

Further reading

• Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID   10493829.
• Hoffmeister A, Ropolo A, Vasseur S, et al. (2002). "The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter". J. Biol. Chem. 277 (25): 22314–9. doi: 10.1074/jbc.M201657200 . PMID   11940591.
• Ree AH, Bratland A, Kroes RA, et al. (2002). "Clinical and cell line specific expression profiles of a human gene identified in experimental central nervous system metastases". Anticancer Res. 22 (4): 1949–57. PMID   12174869.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Jiang WG, Davies G, Fodstad O (2005). "Com-1/P8 in oestrogen regulated growth of breast cancer cells, the ER-beta connection". Biochem. Biophys. Res. Commun. 330 (1): 253–62. doi:10.1016/j.bbrc.2005.02.157. PMID   15781258.
• Mao Y, Zhao Y, Zhou LF, et al. (2006). "A novel gene mutation (1292 deletion) in a Chinese family with cerebral cavernous malformations". Neurosurgery. 56 (5): 1149–53, discussion 1149–53. doi:10.1227/01.NEU.0000157967.67963.7A. PMID   15854263. S2CID   6398096.
• Ito Y, Yoshida H, Motoo Y, et al. (2005). "Expression of p8 protein in medullary thyroid carcinoma". Anticancer Res. 25 (5): 3419–23. PMID   16101158.
• Valacco MP, Varone C, Malicet C, et al. (2006). "Cell growth-dependent subcellular localization of p8". J. Cell. Biochem. 97 (5): 1066–79. doi:10.1002/jcb.20682. hdl: 11336/39067 . PMID   16294328. S2CID   27764122.
• Malicet C, Hoffmeister A, Moreno S, et al. (2006). "Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation". Biochem. Biophys. Res. Commun. 339 (1): 284–9. doi:10.1016/j.bbrc.2005.11.018. PMID   16300740.
• Malicet C, Giroux V, Vasseur S, et al. (2006). "Regulation of apoptosis by the p8/prothymosin alpha complex". Proc. Natl. Acad. Sci. U.S.A. 103 (8): 2671–6. Bibcode:2006PNAS..103.2671M. doi: 10.1073/pnas.0508955103 . PMC   1413786 . PMID   16478804.
• Malicet C, Dagorn JC, Neira JL, Iovanna JL (2006). "p8 and prothymosin alpha: unity is strength". Cell Cycle. 5 (8): 829–30. doi: 10.4161/cc.5.8.2686 . PMID   16628001.
• Jiang WG, Davies G, Martin TA, et al. (2007). "Com-1/p8 acts as a putative tumour suppressor in prostate cancer". Int. J. Mol. Med. 18 (5): 981–6. doi: 10.3892/ijmm.18.5.981 . PMID   17016631.
• Ishida M, Miyamoto M, Naitoh S, et al. (2007). "The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma". Mol. Cell. Biol. 27 (4): 1348–55. doi:10.1128/MCB.00658-06. PMC   1800732 . PMID   17101797.
• Goruppi S, Patten RD, Force T, Kyriakis JM (2007). "Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction". Mol. Cell. Biol. 27 (3): 993–1006. doi:10.1128/MCB.00996-06. PMC   1800682 . PMID   17116693.