NXPH1

NXPH1
Identifiers
Aliases	NXPH1 , NPH1, Nbla00697, neurexophilin 1
External IDs	OMIM: 604639 MGI: 107492 HomoloGene: 8284 GeneCards: NXPH1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	8,752,961 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	9,249,032 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; secondary oocyte; ; prefrontal cortex; ; Left adrenal gland; ; hypothalamus; ; cingulate gyrus; ; Brodmann area 46; ; dorsolateral prefrontal cortex; ; amygdala; ; Brodmann area 9;
	Top expressed in
	medial dorsal nucleus; ; dorsomedial hypothalamic nucleus; ; ventral tegmental area; ; dorsal tegmental nucleus; ; medial vestibular nucleus; ; habenula; ; ventromedial nucleus; ; medial ganglionic eminence; ; substantia nigra; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	More reference expression data
Orthologs
	30010
	18231
	ENSG00000122584
	ENSMUSG00000046178
	P58417
	Q61200
	NM_152745
	NM_008751
	NP_689958
	NP_032777
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Neurexophilin-1 is a protein that in humans is encoded by the NXPH1 gene.^[5]^[6]

This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons.^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000122584 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046178 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Missler M, Sudhof TC (Jun 1998). "Neurexophilins form a conserved family of neuropeptide-like glycoproteins". J Neurosci. 18 (10): 3630–8. doi: 10.1523/JNEUROSCI.18-10-03630.1998 . PMC 6793134 . PMID 9570794.
1 2 "Entrez Gene: NXPH1 neurexophilin 1".

Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Lett. 197 (1–2): 63–68. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
Petrenko AG, Ullrich B, Missler M, et al. (1996). "Structure and evolution of neurexophilin". J. Neurosci. 16 (14): 4360–9. doi: 10.1523/JNEUROSCI.16-14-04360.1996 . PMC 6578849 . PMID 8699246.
Missler M, Hammer RE, Südhof TC (1999). "Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit". J. Biol. Chem. 273 (52): 34716–34723. doi: 10.1074/jbc.273.52.34716 . PMID 9856994.
Clarris HJ, McKeown S, Key B (2003). "Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb". Int. J. Dev. Biol. 46 (4): 649–52. PMID 12141453.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961 . PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–164. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000122584 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046178 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9570794-5] Missler M, Sudhof TC (Jun 1998). "Neurexophilins form a conserved family of neuropeptide-like glycoproteins". J Neurosci. 18 (10): 3630–8. doi: 10.1523/JNEUROSCI.18-10-03630.1998 . PMC 6793134 . PMID 9570794.

[entrez-6] 1 2 "Entrez Gene: NXPH1 neurexophilin 1".

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NXPH1

Related Research Articles

References

Further reading