NXPH1

NXPH1
Identifiers
Aliases	NXPH1 , NPH1, Nbla00697, neurexophilin 1
External IDs	OMIM: 604639; MGI: 107492; HomoloGene: 8284; GeneCards: NXPH1; OMA:NXPH1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p21.3 Start 8,433,609 bp [1] End 8,752,961 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 A1 Start 8,948,431 bp [2] End 9,249,032 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex endothelial cell secondary oocyte prefrontal cortex testicle left adrenal gland left adrenal cortex Hypothalamus cingulate gyrus anterior cingulate cortex Top expressed in lateral septal nucleus medial dorsal nucleus dorsomedial hypothalamic nucleus ventral tegmental area anterior amygdaloid area dorsal tegmental nucleus medial vestibular nucleus habenula lumbar subsegment of spinal cord ventromedial nucleus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 30010 18231 Ensembl ENSG00000122584 ENSMUSG00000046178 UniProt P58417 Q61200 RefSeq (mRNA) NM_152745 NM_008751 RefSeq (protein) NP_689958 NP_032777 Location (UCSC) Chr 7: 8.43 – 8.75 Mb Chr 6: 8.95 – 9.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neurexophilin-1 is a protein that in humans is encoded by the NXPH1 gene. ^{[5] [6]}

This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000122584 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046178 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Missler M, Sudhof TC (Jun 1998). "Neurexophilins form a conserved family of neuropeptide-like glycoproteins". J Neurosci. 18 (10): 3630–8. doi: 10.1523/JNEUROSCI.18-10-03630.1998 . PMC   6793134 . PMID   9570794.
6. "Entrez Gene: NXPH1 neurexophilin 1".

Further reading

• Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Lett. 197 (1–2): 63–68. doi:10.1016/S0304-3835(03)00085-5. PMID   12880961.
• Petrenko AG, Ullrich B, Missler M, et al. (1996). "Structure and evolution of neurexophilin". J. Neurosci. 16 (14): 4360–9. doi: 10.1523/JNEUROSCI.16-14-04360.1996 . PMC   6578849 . PMID   8699246.
• Missler M, Hammer RE, Südhof TC (1999). "Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit". J. Biol. Chem. 273 (52): 34716–34723. doi: 10.1074/jbc.273.52.34716 . PMID   9856994.
• Clarris HJ, McKeown S, Key B (2003). "Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb". Int. J. Dev. Biol. 46 (4): 649–52. PMID   12141453.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–164. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.