Netrin G1

NTNG1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ZYJ
Identifiers
Aliases	NTNG1 , Lmnt1, netrin G1
External IDs	OMIM: 608818 MGI: 1934028 HomoloGene: 8949 GeneCards: NTNG1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	107,484,923 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	110,051,327 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; germinal epithelium; ; entorhinal cortex; ; superior frontal gyrus; ; prefrontal cortex; ; dorsolateral prefrontal cortex; ; parietal pleura; ; hypothalamus; ; postcentral gyrus;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; sciatic nerve; ; subiculum; ; piriform cortex; ; ventral tegmental area; ; habenula; ; inferior colliculus; ; medial vestibular nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; cell adhesion molecule binding ; cell-cell adhesion mediator activity ;
Cellular component	anchored component of membrane ; anchored component of plasma membrane ; membrane ; extracellular region ; plasma membrane ; Schaffer collateral - CA1 synapse ; glutamatergic synapse ; anchored component of presynaptic active zone membrane ;
Biological process	multicellular organism development ; cell differentiation ; axonogenesis ; nervous system development ; C-terminal protein lipidation ; modulation of chemical synaptic transmission ; synaptic membrane adhesion ; motor neuron axon guidance ; animal organ morphogenesis ; tissue development ;
	Sources:Amigo / QuickGO
Orthologs
	22854
	80883
	ENSG00000162631
	ENSMUSG00000059857
	Q9Y2I2
	Q8R4G0
NM_001113226 ; NM_001113228 ; NM_001312688 ; NM_014917 ; NM_001330665 ;
	NM_001372166 ; NM_001372167 ; NM_001372168 ; NM_001372169 ; NM_001372170 ; NM_001372171
NM_001163348 ; NM_001163349 ; NM_001163350 ; NM_001163351 ; NM_030699 ;
	NM_133488
NP_001106697 ; NP_001106699 ; NP_001299617 ; NP_001317594 ; NP_055732 ;
	NP_001359095 ; NP_001359096 ; NP_001359097 ; NP_001359098 ; NP_001359099 ; NP_001359100
	NP_001156820 ; NP_001156821 ; NP_001156822 ; NP_109624 ; NP_597995
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 12, 2022

Netrin-G1 is a protein that in humans is encoded by the NTNG1 gene.^[5]^[6]

Netrin G1 (NTNG1) belongs to a conserved family of proteins that act as axon guidance cues during vertebrate nervous system development (Nakashiba et al., 2000).[supplied by OMIM]^[6]

Related Research Articles

MECP2 is a gene that encodes the protein MECP2. MECP2 appears to be essential for the normal function of nerve cells. The protein seems to be particularly important for mature nerve cells, where it is present in high levels. The MECP2 protein is likely to be involved in turning off several other genes. This prevents the genes from making proteins when they are not needed. Recent work has shown that MECP2 can also activate other genes. The MECP2 gene is located on the long (q) arm of the X chromosome in band 28 ("Xq28"), from base pair 152,808,110 to base pair 152,878,611.

ADGRV1, also known as G protein-coupled receptor 98 (GPR98) or Very Large G-protein coupled receptor 1 (VLGR1), is a protein that in humans is encoded by the GPR98 gene. Several alternatively spliced transcripts have been described.

Probable G-protein coupled receptor 22 is a protein that in humans is encoded by the GPR22 gene.

Roundabout homolog 1 is a protein that in humans is encoded by the ROBO1 gene.

Ephrin A3 is a protein that in humans is encoded by the EFNA3 gene.

Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene.

Neuronal membrane glycoprotein M6-b is a protein that in humans is encoded by the GPM6B gene.

Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene.

Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.

Syntabulin, also known as SYBU, is a human gene.

Netrin receptor UNC5C is a protein that in humans is encoded by the UNC5C gene.

<span class="mw-page-title-main">Carbonic anhydrase 14</span> Protein-coding gene in the species Homo sapiens

Carbonic anhydrase 14 is an enzyme that in humans is encoded by the CA14 gene.

Neurexophilin-1 is a protein that in humans is encoded by the NXPH1 gene.

Netrin-G2 is a protein that in humans is encoded by the NTNG2 gene.

Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene.

Glycine receptor subunit alpha-2 is a protein that in humans is encoded by the GLRA2 gene.

Bardet–Biedl syndrome 10, also known as BBS10 is a human gene.

Asc-type amino acid transporter 1 (Asc-1) is a protein that in humans is encoded by the SLC7A10 gene.

Guanine nucleotide-binding protein G(t) subunit alpha-3, also known as gustducin alpha-3 chain, is a protein subunit that in humans is encoded by the GNAT3 gene.

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162631 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059857 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nakashiba T, Ikeda T, Nishimura S, Tashiro K, Honjo T, Culotti JG, Itohara S (Sep 2000). "Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins". J Neurosci. 20 (17): 6540–50. doi: 10.1523/JNEUROSCI.20-17-06540.2000 . PMC 6772945 . PMID 10964959.
1 2 "Entrez Gene: NTNG1 netrin G1".

Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi: 10.1093/dnares/6.1.63 . PMID 10231032.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Lin JC, Ho WH, Gurney A, Rosenthal A (2004). "The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons". Nat. Neurosci. 6 (12): 1270–6. doi:10.1038/nn1148. PMID 14595443. S2CID 28353131.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551 . PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Fukasawa M, Aoki M, Yamada K, et al. (2004). "Case-control association study of human netrin G1 gene in Japanese schizophrenia". J. Med. Dent. Sci. 51 (2): 121–8. PMID 15508520.
Aoki-Suzuki M, Yamada K, Meerabux J, et al. (2005). "A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia". Biol. Psychiatry. 57 (4): 382–93. doi:10.1016/j.biopsych.2004.11.022. PMID 15705354. S2CID 19932857.
Borg I, Freude K, Kübart S, et al. (2005). "Disruption of Netrin G1 by a balanced chromosome translocation in a girl with Rett syndrome". European Journal of Human Genetics. 13 (8): 921–7. doi: 10.1038/sj.ejhg.5201429 . PMID 15870826.
Meerabux JM, Ohba H, Fukasawa M, et al. (2006). "Human netrin-G1 isoforms show evidence of differential expression". Genomics. 86 (1): 112–6. doi:10.1016/j.ygeno.2005.04.004. PMID 15901489.
Archer HL, Evans JC, Millar DS, et al. (2006). "NTNG1 Mutations are a Rare Cause of Rett Syndrome". American Journal of Medical Genetics. 140 (7): 691–4. doi:10.1002/ajmg.a.31133. PMC 2577736 . PMID 16502428.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.
Nectoux J, Girard B, Bahi-Buisson N, et al. (2007). "Netrin G1 mutations are an uncommon cause of atypical Rett syndrome with or without epilepsy". Pediatr. Neurol. 37 (4): 270–4. doi:10.1016/j.pediatrneurol.2007.06.002. PMID 17903671.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162631 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059857 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10964959-5] Nakashiba T, Ikeda T, Nishimura S, Tashiro K, Honjo T, Culotti JG, Itohara S (Sep 2000). "Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins". J Neurosci. 20 (17): 6540–50. doi: 10.1523/JNEUROSCI.20-17-06540.2000 . PMC 6772945 . PMID 10964959.

[entrez-6] 1 2 "Entrez Gene: NTNG1 netrin G1".

[1]

[2]

[3]

[4]

[5]

[6]

Netrin G1

Related Research Articles

References

Further reading