Nicholas Hastie

Last updated

Professor
Nicholas Hastie
CBE FRS FRSE
Born
Nicholas Dixon Hastie

(1947-03-29) 29 March 1947 (age 77) [1]
Alma mater
Awards
Scientific career
Institutions
Thesis The role of the nucleus in influenza virus replication  (1973)
Website www.ed.ac.uk/profile/professor-nick-hastie

Nicholas Dixon Hastie (born 1947) is a British geneticist, and former Director of the MRC Human Genetics Unit at the University of Edinburgh. [2] [3] [4] [5] [6] [7] [8] [9] [10] [ excessive citations ]

Contents

Education

He attended Colwyn Bay Grammar school (it became Ysgol Eirias in 1967), where he sang in the choral society. [11]

Hastie was educated at the University of Liverpool and the University of Cambridge. [12]

Awards and honours

Hastie was elected a Fellow of the Royal Society in 2002. His nomination reads

Distinguished for his original and varied contributions to mammalian developmental genetics, genome organisation and gene expression. His early work established the abundance of messenger RNAs during mouse development, and led to the cloning of several genes that are expressed specifically in the liver. Further studies of the serpin gene family uncovered the first clear example of "accelerated protein evolution". At this time he also identified several novel repetitive elements in the mouse genome. His group was the first to characterise mammalian telomeres, and to demonstrate telomere shortening with age in man. Nick Hastie's current work is focused on human developmental mutations, notably Wilm's tumour and Aniridia. His group demonstrated that aniridia, and the mouse equivalent, smalleye, are caused by mutations in the PAX6 gene. He continues to make incisive contributions to our understanding of the role of WT1, the candidate Wilm's Tumour gene, in development of the kidney and gonad. [13]

Hastie was also a member of the Faculty of 1000. [14]

Related Research Articles

<span class="mw-page-title-main">Wilms' tumor</span> Rare childhood cancer of the kidneys

Wilms' tumor or Wilms tumor, also known as nephroblastoma, is a cancer of the kidneys that typically occurs in children, and occurs most commonly as a renal tumor in child patients. It is named after Max Wilms, the German surgeon (1867–1918) who first described it.

<span class="mw-page-title-main">Sex-determining region Y protein</span> Protein that initiates male sex determination in therian mammals

Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals. SRY is an intronless sex-determining gene on the Y chromosome. Mutations in this gene lead to a range of disorders of sex development with varying effects on an individual's phenotype and genotype.

WAGR syndrome is a rare genetic syndrome in which affected children are predisposed to develop Wilms' tumour, aniridia, genitourinary anomalies, and mental retardation. The "G" is sometimes instead given as "gonadoblastoma", since the genitourinary anomalies can include tumours of the gonads.

<span class="mw-page-title-main">PAX6</span> Protein-coding gene in humans

Paired box protein Pax-6, also known as aniridia type II protein (AN2) or oculorhombin, is a protein that in humans is encoded by the PAX6 gene.

<span class="mw-page-title-main">T-box</span> Genes that affect limb and heart development

T-box refers to a group of transcription factors involved in embryonic limb and heart development. Every T-box protein has a relatively large DNA-binding domain, generally comprising about a third of the entire protein that is both necessary and sufficient for sequence-specific DNA binding. All members of the T-box gene family bind to the "T-box", a DNA consensus sequence of TCACACCT.

<span class="mw-page-title-main">Wilms tumor protein</span> Transcription factor gene involved in the urogenital system

Wilms tumor protein (WT33) is a protein that in humans is encoded by the WT1 gene on chromosome 11p.

<span class="mw-page-title-main">ATRX</span> Protein-coding gene in humans

Transcriptional regulator ATRX also known as ATP-dependent helicase ATRX, X-linked helicase II, or X-linked nuclear protein (XNP) is a protein that in humans is encoded by the ATRX gene.

<span class="mw-page-title-main">HOXD10</span> Protein-coding gene in humans

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene.

<span class="mw-page-title-main">POT1</span> Protein-coding gene in the species Homo sapiens

Protection of telomeres protein 1 is a protein that in humans is encoded by the POT1 gene.

<span class="mw-page-title-main">TINF2</span> Protein-coding gene in the species Homo sapiens

TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene. TINF2 is a component of the shelterin protein complex found at the end of telomeres.

Veronica van Heyningen is an English geneticist who specialises in the etiology of anophthalmia as an honorary professor at University College London (UCL). She previously served as head of medical genetics at the MRC Human Genetics Unit in Edinburgh and the president of The Genetics Society. In 2014 she became president of the Galton Institute. As of 2019 she chairs the diversity committee of the Royal Society, previously chaired by Uta Frith.

Frasier syndrome is a urogenital anomaly associated with the WT1 gene.

<span class="mw-page-title-main">FANCM</span> Mammalian protein found in Homo sapiens

Fanconi anemia, complementation group M, also known as FANCM is a human gene. It is an emerging target in cancer therapy, in particular cancers with specific genetic deficiencies.

The stem cell theory of aging postulates that the aging process is the result of the inability of various types of stem cells to continue to replenish the tissues of an organism with functional differentiated cells capable of maintaining that tissue's original function. Damage and error accumulation in genetic material is always a problem for systems regardless of the age. The number of stem cells in young people is very much higher than older people and thus creates a better and more efficient replacement mechanism in the young contrary to the old. In other words, aging is not a matter of the increase in damage, but a matter of failure to replace it due to a decreased number of stem cells. Stem cells decrease in number and tend to lose the ability to differentiate into progenies or lymphoid lineages and myeloid lineages.

Sir Michael Rudolf Stratton, is a British clinical scientist and the third director of the Wellcome Trust Sanger Institute. He currently heads the Cancer Genome Project and is a leader of the International Cancer Genome Consortium.

Douglas Roland Higgs FRS is a Professor of Molecular Haematology at the Weatherall Institute of Molecular Medicine, at the University of Oxford. He is known for his work on the regulation of alpha-globin and the genetics of alpha-thalassemia. He is currently working in understanding the mechanisms by which any mammalian gene is switched on and off during differentiation and development.

Sabera Nazneen Rahman is a geneticist who specialises in cancer research and is a non-executive director for AstraZeneca. She was previously head of Genetics and Epidemiology at the Institute of Cancer Research.

<span class="mw-page-title-main">Wendy Bickmore</span> British genome biologist (born 1961)

Wendy Anne Bickmore is a British genome biologist known for her research on the organisation of genomic material in cells.

<span class="mw-page-title-main">Robin Allshire</span> British academic

Robin Campbell Allshire is a British academic who is Professor of Chromosome Biology at University of Edinburgh and a Wellcome Trust Principal Research Fellow. His research group at the Wellcome Trust Centre for Cell Biology focuses on the epigenetic mechanisms governing the assembly of specialised domains of chromatin and their transmission through cell division.

Peter Anthony Koopman is an Australian biologist best known for his role in the discovery and study of the mammalian Y-chromosomal sex-determining gene, Sry.

References

  1. ↑ "HASTIE, Prof. Nicholas Dixon Anne". Who's Who 2014, A & C Black, an imprint of Bloomsbury Publishing plc, 2014; online edn, Oxford University Press.(subscription required)
  2. ↑ "PROFESSOR NICHOLAS HASTIE, CBE FRS FRSE". MRC Human Genetics Unit. Archived from the original on 27 August 2016.
  3. ↑ "MRC Human Genetics Unit".
  4. ↑ Hill, R. E.; Favor, J; Hogan, B. L.; Ton, C. C.; Saunders, G. F.; Hanson, I. M.; Prosser, J; Jordan, T; Hastie, N. D.; Van Heyningen, V (1991). "Mouse small eye results from mutations in a paired-like homeobox-containing gene". Nature. 354 (6354): 522–5. Bibcode:1991Natur.354..522H. doi:10.1038/354522a0. PMID   1684639. S2CID   4317526.
  5. ↑ Alan Wright; Nicholas Hastie, eds. (2007). Genes and common diseases. Cambridge University Press. ISBN   978-0-521-83339-4.
  6. ↑ Nicholas Hastie's publications indexed by the Scopus bibliographic database. (subscription required)
  7. ↑ Hastie, N. D.; Dempster, M.; Dunlop, M. G.; Thompson, A. M.; Green, D. K.; Allshire, R. C. (1990). "Telomere reduction in human colorectal carcinoma and with ageing". Nature. 346 (6287): 866–8. Bibcode:1990Natur.346..866H. doi:10.1038/346866a0. PMID   2392154. S2CID   4258451.
  8. ↑ Teslovich, T. M.; Musunuru, K.; Smith, A. V.; Edmondson, A. C.; Stylianou, I. M.; Koseki, M.; Pirruccello, J. P.; Ripatti, S.; Chasman, D. I.; Willer, C. J.; Johansen, C. T.; Fouchier, S. W.; Isaacs, A.; Peloso, G. M.; Barbalic, M.; Ricketts, S. L.; Bis, J. C.; Aulchenko, Y. S.; Thorleifsson, G.; Feitosa, M. F.; Chambers, J.; Orho-Melander, M.; Melander, O.; Johnson, T.; Li, X.; Guo, X.; Li, M.; Shin Cho, Y.; Jin Go, M.; et al. (2010). "Biological, clinical and population relevance of 95 loci for blood lipids". Nature. 466 (7307): 707–13. Bibcode:2010Natur.466..707T. doi:10.1038/nature09270. PMC   3039276 . PMID   20686565.
  9. ↑ Pritchard-Jones, K; Fleming, S; Davidson, D; Bickmore, W; Porteous, D; Gosden, C; Bard, J; Buckler, A; Pelletier, J; Housman, D; Van Heyningen, Veronica; Hastie, Nicholas (1990). "The candidate Wilms' tumour gene is involved in genitourinary development". Nature. 346 (6280): 194–7. Bibcode:1990Natur.346..194P. doi:10.1038/346194a0. PMID   2164159. S2CID   4350729.
  10. ↑ Hastie, N (2012). "Linking genetics with biology in disease research: An interview with Nick Hastie". Disease Models & Mechanisms. 5 (2): 151–4. doi:10.1242/dmm.009605. PMC   3291636 . PMID   22382364.
  11. ↑ North Wales Weekly News Thursday 29 March 1962, page 15
  12. ↑ Hastie, Nicholas (1973). The role of the nucleus in influenza virus replication (PhD thesis). University of Cambridge.
  13. ↑ "EC/2002/13: Hastie, Nicholas Dixon". London: The Royal Society. Archived from the original on 11 May 2017.
  14. ↑ "Nicholas Hastie | Faculty Member | Faculty Opinions". facultyopinions.com.
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