Nobel disease or Nobelitis is an informal term for the embrace of strange or scientifically unsound ideas by some Nobel Prize winners, usually later in life. [1] [2] [3] It has been argued that the effect results, in part, from a tendency for Nobel winners to feel empowered by the award to speak on topics outside their specific area of expertise, [4] [5] [6] although it is unknown whether Nobel Prize winners are more prone to this tendency than other individuals. [7] Paul Nurse, co-winner of the 2001 Nobel Prize in Physiology or Medicine, warned later laureates against "believing you are expert in almost everything, and being prepared to express opinions about most issues with great confidence, sheltering behind the authority that the Nobel Prize can give you". [8] Nobel disease has been described as a tongue-in-cheek term. [5]
While it remains unclear whether Nobel winners are statistically more prone to critical thinking errors than other scientists, the phenomenon is of interest because it provides an existence proof that being an authority in one field does not necessarily make one an authority in any other field, and, to the extent that winning a Nobel Prize serves as a proxy indicator of scientific brilliance and high general intelligence, such characteristics are not incompatible with irrationality. [9] [7]
Nobel disease also serves to demonstrate that, for some prize winners, being universally hailed as correct appears to bolster the individual laureate's confirmation bias more than it does their skepticism. [10] Milton Friedman, winner of the Nobel Memorial Prize in Economic Sciences in 1976, said of the Nobel disease, as it relates to his economic thinking towards an "antidote", the following: [11]
I myself have been asked my opinion on everything from a cure for the common cold to the market value of a letter signed by John F. Kennedy. Needless to say the attention [from receiving a Nobel prize] is flattering, but also corrupting. Somehow we badly need an antidote for both the inflated attention granted a Nobel laureate in areas outside his competence and the inflated ego each of us is in danger of acquiring. My own field suggests one obvious antidote: competition through the establishment of many more awards. But a product that has been so successful is not easy to replace. Hence, I suspect that our inflated egos are safe for a good long time to come. [11]
Charles Richet won the 1913 Nobel Prize in Physiology or Medicine for his research on anaphylaxis. He also believed in extrasensory perception, paranormal activity, dowsing, and ghosts. [7]
Linus Pauling won the 1954 Nobel Prize in Chemistry for his work on chemical bonds and the Nobel Peace prize in 1962 for his peace activism. A decade before winning the first prize, he was diagnosed with Bright's disease which he treated in part by ingesting vitamin supplements, which he claimed dramatically improved his condition. He later espoused taking high doses of vitamin C to reduce the likelihood and severity of experiencing the common cold. Pauling himself consumed amounts of vitamin C on a daily basis that were more than 120 times the recommended daily intake. He further argued that megadoses of vitamin C have therapeutic value for treating schizophrenia and for prolonging cancer patients' lives. These claims are not supported by the best available science. [9] [1] [2]
William Shockley, who won the 1956 Nobel Prize in Physics for his invention of the transistor, promoted racialism and eugenics. [4] [9]
James Watson was awarded the 1962 Nobel Prize in Physiology or Medicine, together with Francis Crick and Maurice Wilkins, "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material". Since at least 2000, Watson has consistently and publicly claimed that black people are inherently less intelligent than white people, and that exposure to sunlight in tropical regions and higher levels of melanin cause dark-skinned people to have a higher sex drive. [9] [12] [13]
Nikolaas Tinbergen won the 1973 Nobel Prize in Physiology or Medicine for discoveries concerning the organization and elicitation of individual and social behavior patterns in animals. During his Nobel acceptance speech, Tinbergen promoted the widely discredited [14] "refrigerator mother" hypothesis of the causation of autism, thereby setting a "nearly unbeatable record for shortest time between receiving the Nobel Prize and saying something really stupid about a field in which the recipient had little experience." [2] In 1985, Tinbergen coauthored a book with his wife [15] that recommended the use of "holding therapy" for autism, a form of treatment that is empirically unsupported and that can be physically dangerous. [1] [9]
Brian Josephson won the Nobel Prize in Physics in 1973 for his prediction of the Josephson effect. Josephson has promoted a number of scientifically unsupported or discredited beliefs, including the homeopathic notion that water can somehow "remember" the chemical properties of substances diluted within it, the view that transcendental meditation is helpful for bringing unconscious traumatic memories into conscious awareness, and the possibility that humans can communicate with each other by telepathy. [9]
Kary Mullis won the 1993 Nobel Prize in Chemistry for development of the polymerase chain reaction. Mullis disagreed with the scientifically accepted view that AIDS is caused by HIV, claiming that the virus is barely detectable in people with the disease. He also expressed doubt in the evidence for human-caused climate change. In his autobiography, Mullis professed a belief in astrology and wrote about an encounter with a fluorescent, talking raccoon that he suggested might have been an extraterrestrial alien. [4] [9]
Luc Montagnier co-discovered HIV in 1980, for which he won the 2008 Nobel Prize in Physiology or Medicine. In 2009, in a non-peer-reviewed paper in a journal that he had founded, Montagnier claimed that solutions containing the DNA of pathogenic bacteria and viruses could emit low frequency radio waves that induce surrounding water molecules to become arranged into "nanostructures". He suggested water could retain such properties even after the original solutions were massively diluted, to the point where the original DNA had effectively vanished, and that water could retain the "memory" of substances with which it had been in contact – claims that place his work in close alignment with the pseudoscientific tenets of homeopathy. He further claimed that DNA sequence information could be 'teleported' to a separate test tube of purified water via these radio waves. He explained this in the framework of quantum field theory. [16] [2] [17] He has supported the scientifically discredited view that vaccines cause autism and has claimed that antibiotics are of therapeutic value in the treatment of autism. [9]
Kary Banks Mullis was an American biochemist. In recognition of his role in the invention of the polymerase chain reaction (PCR) technique, he shared the 1993 Nobel Prize in Chemistry with Michael Smith and was awarded the Japan Prize in the same year. PCR became a central technique in biochemistry and molecular biology, described by The New York Times as "highly original and significant, virtually dividing biology into the two epochs of before PCR and after PCR."
The Nobel Prizes are five separate prizes that, according to the 1895 will of Alfred Nobel, a Swedish chemist, engineer, and industrialist who invented dynamite, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfred Nobel died the following year, and prizes were first awarded in 1901. A sixth prize, for Economic Sciences, established by the Bank of Sweden, is usually also included.
Linus Carl Pauling was an American chemist, biochemist, chemical engineer, peace activist, author, and educator. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics. New Scientist called him one of the 20 greatest scientists of all time. For his scientific work, Pauling was awarded the Nobel Prize in Chemistry in 1954. For his peace activism, he was awarded the Nobel Peace Prize in 1962. He is one of five people to have won more than one Nobel Prize. Of these, he is the only person to have been awarded two unshared Nobel Prizes, and one of two people to be awarded Nobel Prizes in different fields, the other being Marie Curie.
The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, according to Alfred Nobel's 1895 will, are awarded "to those who, during the preceding year, have conferred the greatest benefit to humankind". Nobel Prizes are awarded in the fields of Physics, Chemistry, Physiology or Medicine, Literature and Peace.
Stanley Ben Prusiner is an American neurologist and biochemist. He is the director of the Institute for Neurodegenerative Diseases at University of California, San Francisco (UCSF). Prusiner discovered prions, a class of infectious self-reproducing pathogens primarily or solely composed of protein, considered by many as a heretical idea when first proposed. He received the Albert Lasker Award for Basic Medical Research in 1994 and the Nobel Prize in Physiology or Medicine in 1997 for prion research developed by him and his team of experts beginning in the early 1970s.
Nikolaas "Niko" Tinbergen was a Dutch biologist and ornithologist who shared the 1973 Nobel Prize in Physiology or Medicine with Karl von Frisch and Konrad Lorenz for their discoveries concerning the organization and elicitation of individual and social behavior patterns in animals. He is regarded as one of the founders of modern ethology, the study of animal behavior.
Salvador Edward Luria was an Italian microbiologist, later a naturalized U.S. citizen. He won the Nobel Prize in Physiology or Medicine in 1969, with Max Delbrück and Alfred Hershey, for their discoveries on the replication mechanism and the genetic structure of viruses. Salvador Luria also showed that bacterial resistance to viruses (phages) is genetically inherited.
William Parry Murphy Sr. was an American physician who shared the Nobel Prize in Physiology or Medicine in 1934 with George Richards Minot and George Hoyt Whipple for their combined work in devising and treating macrocytic anemia.
Luc Montagnier was a French virologist and joint recipient, with Françoise Barré-Sinoussi and Harald zur Hausen, of the 2008 Nobel Prize in Physiology or Medicine for his discovery of the human immunodeficiency virus (HIV). He worked as a researcher at the Pasteur Institute in Paris and as a full-time professor at Shanghai Jiao Tong University in China.
George Wald was an American scientist and activist who studied pigments in the retina. He won a share of the 1967 Nobel Prize in Physiology or Medicine with Haldan Keffer Hartline and Ragnar Granit.
Water memory is the purported ability of water to retain a memory of substances previously dissolved in it even after an arbitrary number of serial dilutions. It has been claimed to be a mechanism by which homeopathic remedies work, even when they are diluted to the point that no molecule of the original substance remains, but there is no evidence for it.
Edmond Henri Fischer was a Swiss-American biochemist. He and his collaborator Edwin G. Krebs were awarded the Nobel Prize in Physiology or Medicine in 1992 for describing how reversible phosphorylation works as a switch to activate proteins and regulate various cellular processes. From 2007 until 2014, he was the Honorary President of the World Cultural Council. At the time of his death at age 101 in 2021, he was the oldest living Nobel Prize laureate.
Randy Wayne Schekman is an American cell biologist at the University of California, Berkeley, former editor-in-chief of Proceedings of the National Academy of Sciences and former editor of Annual Review of Cell and Developmental Biology. In 2011, he was announced as the editor of eLife, a new high-profile open-access journal published by the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust launching in 2012. He was elected to the National Academy of Sciences in 1992. Schekman shared the 2013 Nobel Prize for Physiology or Medicine with James Rothman and Thomas C. Südhof for their ground-breaking work on cell membrane vesicle trafficking.
Vitamin C and the Common Cold is a popular book by Linus Pauling, first published in 1970, on vitamin C, its interactions with common cold and the role of vitamin C megadosage in human health. The book promoted the idea that taking large amounts of vitamin C could reduce the duration and severity of the common cold. A Nobel Prize-winning chemist and activist, Pauling promoted a view of vitamin C that is strongly at odds with most of the scientific community, which found little evidence for the alleged health benefits of greatly increased vitamin C intake. The book went through multiple editions, and a revised version that discussed the flu and other diseases, retitled Vitamin C, the Common Cold & the Flu, came out in 1976.
The Nobel Prize in Chemistry is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for outstanding contributions in chemistry, physics, literature, peace, and physiology or medicine. This award is administered by the Nobel Foundation, and awarded by the Royal Swedish Academy of Sciences on proposal of the Nobel Committee for Chemistry which consists of five members elected by the Academy. The award is presented in Stockholm at an annual ceremony on 10 December, the anniversary of Nobel's death.
Thomas Christian Südhof, ForMemRS, is a German-American biochemist known for his study of synaptic transmission. Currently, he is a professor in the school of medicine in the department of molecular and cellular physiology, and by courtesy in neurology, and in psychiatry and behavioral sciences at Stanford University.
The Massry Prize was established in 1996, and was administered by the Meira and Shaul G. Massry Foundation until 2019. The Prize, of $40,000 and the Massry Lectureship, is bestowed upon scientists who have made substantial recent contributions in the biomedical sciences. Shaul G. Massry, M.D., who established the Massry Foundation, is Professor Emeritus of Medicine and Physiology and Biophysics at the Keck School of Medicine, University of Southern California. He served as Chief of its Division of Nephrology from 1974 to 2000. In 2009 the KECK School of Medicine was asked to administer the Prize, and has done so since that time. Ten winners of the Massry Prize have gone on to be awarded a Nobel Prize.
Tasuku Honjo is a Japanese physician-scientist and immunologist. He won the 2018 Nobel Prize in Physiology or Medicine and is best known for his identification of programmed cell death protein 1 (PD-1). He is also known for his molecular identification of cytokines: IL-4 and IL-5, as well as the discovery of activation-induced cytidine deaminase (AID) that is essential for class switch recombination and somatic hypermutation.
The Nobel Prize effect is an observation about the adverse effects of receiving the Nobel Prize on laureates and their careers. These effects include reduced productivity, constraints in areas of work, and public perception of expertise in areas unrelated to the laureate's work. The term Nobel effect is also used in those contexts, as well as in the context of the laureate's longevity, and influence on international law in the case of the Nobel Peace Prize.
DNA teleportation is a pseudoscientific claim which suggests that DNA can produce electromagnetic signals (EMS) that are measurable when highly diluted in water. The claim suggests these signals can allegedly be recorded, transmitted electronically and re-emitted on another distant pure water sample, where the DNA can replicate through polymerase chain reaction, despite the absence of the original DNA in the new water sample. The idea was introduced by the Nobel laureate Luc Montagnier in 2009. It is similar in principle to water memory, a similar pseudoscientific claim popularised by Jacques Benveniste in 1988.
