Nucleolar and spindle associated protein 1

NUSAP1
Identifiers
Aliases	NUSAP1 , ANKT, BM037, LNP, NUSAP, PRO0310p1, Q0310, SAPL, nucleolar and spindle associated protein 1
External IDs	OMIM: 612818; MGI: 2675669; HomoloGene: 10207; GeneCards: NUSAP1; OMA:NUSAP1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q15.1 Start 41,320,794 bp [1] End 41,381,050 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E5 Start 119,448,779 bp [2] End 119,481,725 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence bone marrow bone marrow cell gonad appendix lymph node stromal cell of endometrium rectum right adrenal cortex Top expressed in genital tubercle fetal liver hematopoietic progenitor cell medial ganglionic eminence blood primary oocyte tibiofemoral joint zygote tail of embryo dermis thymus More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding DNA binding protein binding RNA binding Cellular component spindle spindle microtubule cytoskeleton microtubule chromosome nucleus nucleolus cytoplasm mitotic spindle Biological process cell division cell cycle mitotic cytokinesis mitotic chromosome condensation establishment of mitotic spindle localization positive regulation of mitotic nuclear division microtubule cytoskeleton organization mitotic sister chromatid segregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51203 108907 Ensembl ENSG00000137804 ENSMUSG00000027306 UniProt Q9BXS6 Q9ERH4 RefSeq (mRNA) NM_001129897 NM_001243142 NM_001243143 NM_001243144 NM_001301136 NM_016359 NM_018454 NM_001042652 NM_133851 RefSeq (protein) NP_001230071 NP_001230072 NP_001230073 NP_001288065 NP_057443 NP_060924 NP_001036117 NP_598612 Location (UCSC) Chr 15: 41.32 – 41.38 Mb Chr 2: 119.45 – 119.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nucleolar and spindle associated protein 1 is a protein that in humans is encoded by the NUSAP1 gene. ^[5]

Function

NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009].

References

1. GRCh38: Ensembl release 89: ENSG00000137804 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027306 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Nucleolar and spindle associated protein 1" . Retrieved 2018-05-22.

Further reading

• Wadia PP, Coram M, Armstrong RJ, Mindrinos M, Butte AJ, Miklos DB (March 2010). "Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation". Blood. 115 (10): 2077–87. doi:10.1182/blood-2009-03-211375. PMC   2837325 . PMID   20053754.
• Verbakel W, Carmeliet G, Engelborghs Y (August 2011). "SAP-like domain in nucleolar spindle associated protein mediates mitotic chromosome loading as well as interphase chromatin interaction". Biochem. Biophys. Res. Commun. 411 (4): 732–7. doi:10.1016/j.bbrc.2011.07.015. PMID   21782797.
• Chou HY, Wang TH, Lee SC, Hsu PH, Tsai MD, Chang CL, Jeng YM (December 2011). "Phosphorylation of NuSAP by Cdk1 regulates its interaction with microtubules in mitosis". Cell Cycle. 10 (23): 4083–9. doi: 10.4161/cc.10.23.18200 . PMID   22101338.
• Gulzar ZG, McKenney JK, Brooks JD (January 2013). "Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1". Oncogene. 32 (1): 70–7. doi:10.1038/onc.2012.27. PMC   3360134 . PMID   22349817.
• Espinosa AM, Alfaro A, Roman-Basaure E, Guardado-Estrada M, Palma Í, Serralde C, Medina I, Juárez E, Bermúdez M, Márquez E, Borges-Ibáñez M, Muñoz-Cortez S, Alcántara-Vázquez A, Alonso P, Curiel-Valdez J, Kofman S, Villegas N, Berumen J (2013). "Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer". PLOS ONE. 8 (2) e55975. Bibcode:2013PLoSO...855975E. doi: 10.1371/journal.pone.0055975 . PMC   3566100 . PMID   23405241.
• Kotian S, Banerjee T, Lockhart A, Huang K, Catalyurek UV, Parvin JD (May 2014). "NUSAP1 influences the DNA damage response by controlling BRCA1 protein levels". Cancer Biol. Ther. 15 (5): 533–43. doi:10.4161/cbt.28019. PMC   4026076 . PMID   24521615.
• Chen L, Yang L, Qiao F, Hu X, Li S, Yao L, Yang XL, Shao ZM (2015). "High Levels of Nucleolar Spindle-Associated Protein and Reduced Levels of BRCA1 Expression Predict Poor Prognosis in Triple-Negative Breast Cancer". PLOS ONE. 10 (10) e0140572. Bibcode:2015PLoSO..1040572C. doi: 10.1371/journal.pone.0140572 . PMC   4618922 . PMID   26485712.
• Okamoto A, Higo M, Shiiba M, Nakashima D, Koyama T, Miyamoto I, Kasama H, Kasamatsu A, Ogawara K, Yokoe H, Tanzawa H, Uzawa K (2015). "Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma". PLOS ONE. 10 (11) e0142252. Bibcode:2015PLoSO..1042252O. doi: 10.1371/journal.pone.0142252 . PMC   4640814 . PMID   26554377.
• Li C, Zhang Y, Yang Q, Ye F, Sun SY, Chen ES, Liou YC (January 2016). "NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity". Sci Rep. 6 18773. Bibcode:2016NatSR...618773L. doi:10.1038/srep18773. PMC   4702128 . PMID   26733216.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.