OPCML

OPCML
Identifiers
Aliases	OPCML , IGLON1, OBCAM, OPCM, opioid binding protein/cell adhesion molecule-like, opioid binding protein/cell adhesion molecule like
External IDs	OMIM: 600632 MGI: 97397 HomoloGene: 55663 GeneCards: OPCML
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q25 Start 132,414,977 bp [1] End 133,532,501 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 A4|9 13.73 cM Start 27,790,775 bp [2] End 28,925,410 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus endothelial cell retinal pigment epithelium orbitofrontal cortex postcentral gyrus superior frontal gyrus Brodmann area 46 entorhinal cortex Region I of hippocampus proper Top expressed in primary motor cortex ventromedial nucleus cingulate gyrus subiculum piriform cortex lateral geniculate nucleus prefrontal cortex lateral hypothalamus habenula superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component anchored component of membrane plasma membrane membrane extracellular region Biological process neuron recognition cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4978 330908 Ensembl ENSG00000183715 ENSMUSG00000062257 UniProt Q14982 n/a RefSeq (mRNA) NM_001012393 NM_002545 NM_001319103 NM_001319104 NM_001319105 NM_001319106 NM_177906 RefSeq (protein) NP_001012393 NP_001306032 NP_001306033 NP_001306034 NP_001306035 NP_002536 NP_002536.1 n/a Location (UCSC) Chr 11: 132.41 – 133.53 Mb Chr 9: 27.79 – 28.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Opioid-binding protein/cell adhesion molecule is a protein that in humans is encoded by the OPCML gene. ^{[5] [6]}

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the cell membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000183715 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062257 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y, et al. (Dec 1993). "A sequence-tagged site map of human chromosome 11". Genomics. 17 (3): 699–725. doi:10.1006/geno.1993.1392. PMID   8244387.
6. "Entrez Gene: OPCML opioid binding protein/cell adhesion molecule-like".

Further reading

• Lane CM, Elde R, Loh HH, Lee NM (1993). "Regulation of an opioid-binding protein in NG108-15 cells parallels regulation of delta-opioid receptors". Proc. Natl. Acad. Sci. U.S.A. 89 (23): 11234–8. doi: 10.1073/pnas.89.23.11234 . PMC   50524 . PMID   1333602.
• Shark KB, Lee NM (1995). "Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM)". Gene. 155 (2): 213–7. doi:10.1016/0378-1119(94)00830-L. PMID   7721093.
• Struyk AF, Canoll PD, Wolfgang MJ, et al. (1995). "Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules". J. Neurosci. 15 (3 Pt 2): 2141–56. doi: 10.1523/JNEUROSCI.15-03-02141.1995 . PMC   6578143 . PMID   7891157.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Sellar GC, Watt KP, Rabiasz GJ, et al. (2003). "OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer". Nat. Genet. 34 (3): 337–43. doi:10.1038/ng1183. PMID   12819783. S2CID   24411276.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Schmitt-Ulms G, Hansen K, Liu J, et al. (2005). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nat. Biotechnol. 22 (6): 724–31. doi:10.1038/nbt969. PMID   15146195. S2CID   36630738.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Mei FC, Young TW, Liu J, Cheng X (2006). "RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells". FASEB J. 20 (3): 497–9. doi: 10.1096/fj.05-4586fje . PMID   16384911. S2CID   24792515.
• Wang L, Zhu JS, Song MQ, et al. (2007). "Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray". World J. Gastroenterol. 12 (43): 6949–54. doi: 10.3748/wjg.v12.i43.6949 . PMC   4087337 . PMID   17109515.
• Czekierdowski A, Czekierdowska S, Szymanski M, et al. (2007). "Opioid-binding protein/cell adhesion molecule-like (OPCML) gene and promoter methylation status in women with ovarian cancer". Neuro Endocrinol. Lett. 27 (5): 609–13. PMID   17159813.
• Reed JE, Dunn JR, du Plessis DG, et al. (2007). "Expression of cellular adhesion molecule 'OPCML' is down-regulated in gliomas and other brain tumours". Neuropathol. Appl. Neurobiol. 33 (1): 77–85. doi:10.1111/j.1365-2990.2006.00786.x. PMID   17239010. S2CID   22479211.

External links

• Overview of all the structural information available in the PDB for UniProt : Q14982 (Opioid-binding protein/cell adhesion molecule) at the PDBe-KB .