OSBPL3

OSBPL3
Identifiers
Aliases	OSBPL3 , ORP-3, ORP3, OSBP3, oxysterol binding protein like 3
External IDs	OMIM: 606732 MGI: 1918970 HomoloGene: 49422 GeneCards: OSBPL3
Gene location (Human)
Chr.	Chromosome 7 (human)
End	24,981,634 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	50,433,181 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; amniotic fluid; ; oocyte; ; secondary oocyte; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; stromal cell of endometrium; ; skin of abdomen; ; lymph node; ; Achilles tendon;
	Top expressed in
	epithelium of stomach; ; proximal tubule; ; kidney; ; otolith organ; ; utricle; ; ascending aorta; ; adrenal gland; ; duodenum; ; skin of abdomen; ; jejunum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cholesterol binding ; protein binding ; lipid binding ; sterol transporter activity ; sterol binding ;
Cellular component	perinuclear endoplasmic reticulum ; cell projection ; cytoplasm ; endoplasmic reticulum membrane ; filopodium tip ; nuclear membrane ; endoplasmic reticulum ; plasma membrane ; nucleus ; membrane ; cytosol ; intracellular membrane-bounded organelle ;
Biological process	lipid transport ; bile acid biosynthetic process ; sterol transport ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	26031
	71720
	ENSG00000070882
	ENSMUSG00000029822
	Q9H4L5
	Q9DBS9
NM_015550 ; NM_145320 ; NM_145321 ; NM_145322 ; NM_145323 ;
	NM_145324
	NM_001163645 ; NM_027881 ; NM_001347213
	NP_056365 ; NP_663160 ; NP_663161 ; NP_663162
	NP_001157117 ; NP_001334142 ; NP_082157
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 08, 2024

Oxysterol-binding protein-related protein 3 is a protein that in humans is encoded by the OSBPL3 gene.^[5]^[6]

Function

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Several transcript variants encoding different isoforms have been identified.^[6]

Related Research Articles

The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR. Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear receptors, however, upon discovery of endogenous oxysterols as ligands they were subsequently deorphanized.

Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene.

Phospholipid transfer protein is a protein that in humans is encoded by the PLTP gene.

Non-specific lipid-transfer protein also known as sterol carrier protein 2 (SCP-2) or propanoyl-CoA C-acyltransferase is a protein that in humans is encoded by the SCP2 gene.

ATP-binding cassette sub-family G member 1 is a protein that in humans is encoded by the ABCG1 gene. It is a homolog of the well-known Drosophila gene white.

CD2-associated protein is a protein that in humans is encoded by the CD2AP gene.

Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene.

<span class="mw-page-title-main">Oxysterol-binding protein</span>

The oxysterol-binding protein (OSBP)-related proteins (ORPs) are a family of lipid transfer proteins (LTPs). Concretely, they constitute a family of sterol and phosphoinositide binding and transfer proteins in eukaryotes that are conserved from yeast to humans. They are lipid-binding proteins implicated in many cellular processes related with oxysterol, including signaling, vesicular trafficking, lipid metabolism, and nonvesicular sterol transport.

Oxysterol-binding protein-related protein 5 is a protein that in humans is encoded by the OSBPL5 gene.

VAMP-Associated Protein A is a protein that in humans is encoded by the VAPA gene. Together with VAPB and VAPC it forms the VAP protein family. They are integral endoplasmic reticulum membrane proteins of the type II and are ubiquitous among eukaryotes.

25-hydroxycholesterol 7-alpha-hydroxylase also known as oxysterol and steroid 7-alpha-hydroxylase is an enzyme that in humans is encoded by the CYP7B1 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

Oxysterol-binding protein 1 is a protein that in humans is encoded by the OSBP gene.

Oxysterol-binding protein-related protein 11 is a protein that in humans is encoded by the OSBPL11 gene.

Oxysterol-binding protein 2 is a protein that in humans is encoded by the OSBP2 gene.

45 kDa calcium-binding protein is a protein that in humans is encoded by the SDF4 gene.

Oxysterol-binding protein-related protein 1 is a protein that in humans is encoded by the OSBPL1A gene.

Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.

<span class="mw-page-title-main">OSBPL2</span> Protein-coding gene in the species Homo sapiens

Oxysterol-binding protein-related protein 2 is a protein that in humans is encoded by the OSBPL2 gene.

Syntaxin 3, also known as STX3, is a protein which in humans is encoded by the STX3 gene.

Oxysterol binding protein-like 9 is a protein that in humans is encoded by the OSBPL9 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000070882 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029822 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID 9734811.
1 2 "Entrez Gene: OSBPL3 oxysterol binding protein-like 3".

Sanger Centre T, Washington University Genome Sequencing Cente T (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID 9847074.
Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (Dec 1999). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". Journal of Lipid Research. 40 (12): 2204–11. doi: 10.1016/S0022-2275(20)32095-2 . PMID 10588946.
Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, Ikonen E, Olkkonen VM (Aug 2001). "The OSBP-related protein family in humans". Journal of Lipid Research. 42 (8): 1203–13. doi: 10.1016/S0022-2275(20)31570-4 . PMID 11483621.
Gregorio-King CC, Collier GR, McMillan JS, Waugh CM, McLeod JL, Collier FM, Kirkland MA (Oct 2001). "ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells". Blood. 98 (7): 2279–81. doi: 10.1182/blood.V98.7.2279 . PMID 11568019.
Jaworski CJ, Moreira E, Li A, Lee R, Rodriguez IR (Dec 2001). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225.
Collier FM, Gregorio-King CC, Apostolopoulos J, Walder K, Kirkland MA (Jan 2003). "ORP3 splice variants and their expression in human tissues and hematopoietic cells". DNA and Cell Biology. 22 (1): 1–9. doi:10.1089/104454903321112442. hdl: 10536/DRO/DU:30009437 . PMID 12590732.
Lehto M, Tienari J, Lehtonen S, Lehtonen E, Olkkonen VM (Jan 2004). "Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7". Cell and Tissue Research. 315 (1): 39–57. doi:10.1007/s00441-003-0817-y. PMID 14593528. S2CID 21298003.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID 15324660. S2CID 2371325.
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID 15778465.
Lehto M, Hynynen R, Karjalainen K, Kuismanen E, Hyvärinen K, Olkkonen VM (Nov 2005). "Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants". Experimental Cell Research. 310 (2): 445–62. doi:10.1016/j.yexcr.2005.08.003. PMID 16143324.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000070882 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029822 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID 9734811.

[entrez-6] 1 2 "Entrez Gene: OSBPL3 oxysterol binding protein-like 3".

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OSBPL3

Contents

Function

Related Research Articles

References

Further reading