OTUD7B

OTUD7B
Identifiers
Aliases	OTUD7B , CEZANNE, ZA20D1, OTU deubiquitinase 7B
External IDs	OMIM: 611748 MGI: 2654703 HomoloGene: 10624 GeneCards: OTUD7B
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.2 Start 149,937,812 bp [1] End 150,010,726 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.1 Start 96,011,839 bp [2] End 96,068,446 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus sural nerve secondary oocyte corpus callosum inferior ganglion of vagus nerve muscle of leg gastrocnemius muscle subthalamic nucleus stromal cell of endometrium external globus pallidus Top expressed in blood retinal pigment epithelium sciatic nerve right lung lobe spermatid spermatocyte triceps brachii muscle aortic valve substantia nigra cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding cysteine-type peptidase activity zinc ion binding metal ion binding peptidase activity K63-linked polyubiquitin modification-dependent protein binding protein binding thiol-dependent deubiquitinase hydrolase activity Lys48-specific deubiquitinase activity Cellular component cytoplasm nucleus cytosol Biological process mucosal immune response negative regulation of protein localization to nucleus protein K48-linked deubiquitination protein deubiquitination involved in ubiquitin-dependent protein catabolic process immune system process negative regulation of transcription by RNA polymerase II negative regulation of I-kappaB kinase/NF-kappaB signaling proteolysis negative regulation of interleukin-8 production protein K63-linked deubiquitination immune response protein deubiquitination protein K11-linked deubiquitination adaptive immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56957 229603 Ensembl ENSG00000264522 ENSMUSG00000038495 UniProt Q6GQQ9 B2RUR8 RefSeq (mRNA) NM_020205 NM_001025613 NM_001025614 RefSeq (protein) NP_064590 NP_001020784 NP_001020785 Location (UCSC) Chr 1: 149.94 – 150.01 Mb Chr 3: 96.01 – 96.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

OTU domain-containing protein 7B is a protein that in humans is encoded by the OTUD7B gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000264522 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038495 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ (Jul 2001). "Isolation and characterization of two novel A20-like proteins". Biochemical Journal. 357 (Pt 3): 617–23. doi:10.1042/0264-6021:3570617. PMC   1221992 . PMID   11463333.
6. "Entrez Gene: OTUD7B OTU domain containing 7B".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research . 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America . 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Evans PC, Ovaa H, Hamon M, et al. (2004). "Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity". Biochem. J. 378 (Pt 3): 727–34. doi:10.1042/BJ20031377. PMC   1224040 . PMID   14748687.
• Evans PC, Smith TS, Lai MJ, et al. (2003). "A novel type of deubiquitinating enzyme". Journal of Biological Chemistry . 278 (25): 23180–6. doi: 10.1074/jbc.M301863200 . PMID   12682062.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Heyninck K, Beyaert R (1999). "The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6". FEBS Letters . 442 (2–3): 147–50. doi: 10.1016/S0014-5793(98)01645-7 . PMID   9928991.