Occupational cancer

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Occupational cancer is cancer caused by occupational hazards. Several cancers have been directly tied to occupational hazards, including chimney sweeps' carcinoma, mesothelioma, and others.

Contents

Types of hazards

Occupational exposure to chemicals, dusts, radiation, and certain industrial processes have been tied to occupational cancer. Exposure to cancer-causing chemicals (carcinogens) may cause mutations that allow cells to grow out of control, causing cancer. Carcinogens in the workplace may include chemicals like anilines, chromates, dinitrotoluenes, arsenic and inorganic arsenic compounds, beryllium and beryllium compounds, cadmium compounds, and nickel compounds. [1] Dusts that can cause cancer leather or wood dusts, asbestos, [2] crystalline forms of silica, coal tar pitch volatiles, coke oven emissions, diesel exhaust and environmental tobacco smoke. [1] sunlight; radon gas; and industrial, medical, or other exposure to ionizing radiation can all cause cancer in the workplace. Industrial processes associated with cancer include aluminum production; iron and steel founding; and underground mining with exposure to uranium or radon. Shift work, which can disturb the circadian rhythm, has also been identified as a risk factor for some forms of cancer, in particular for breast cancer. [3] [4] [5]

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Other risk factors for cancer include: [6] [7] [8]

Types of cancers

Common cancers and their exposures and occupations include: [2]

CancerSourceExamples of Occupations
Bladder Benzidine, beta-naphthylamine,

4-aminobiphenyl, arsenic

Rubber, leather, paving, roofing,

printing and textile industries; paint/

dyeing products; chimney sweeping;

machinists; hairdressers and barbers;

truck drivers

Kidney Cadmium, trichloroethylene, herbicides,

wood dust

Painting; metalworking; petroleum,

plastics, and textile industries

Larynx Asbestos, wood dust, paint fumesMetal working; petroleum, rubber,

plastics, and textile industries

Leukemia Formaldehyde, benzene, ethylene

oxide, pesticides

Rubber manufacturing; oil refining;

shoemaking, funeral embalming

Liver Arsenic, vinyl chloride, aflatoxinsPlastic manufacturing
Lung Radon, secondhand smoke, asbestos,

arsenic, cadmium, chromium compounds,

diesel exhaust, sulfur mustard

Rubber manufacturing, paving,

roofing, painting, chimney sweeping,

iron and steel foundry work, welding

Lymphoma Benzene, 1, 3-butadiene, ethylene

oxide, herbicides, insecticides

Rubber manufacturing, painting,

hairdresser or barber

Mesothelioma AsbestosMining, railroad, automotive,

plumbing, painting and construction

industries; factory workers

Nasal cavity and sinus Mustard gas, nickel dust, chromium

dust, leather dust, wood dust, radium

Textile and baking industry, flour

milling, nickel refining, furniture and

cabinet builders, shoemaking

Skin Arsenic, coal tars, paraffin, certain oils,

sunlight

Chimney sweeping; outside jobs that

involve a lot of sun exposure

Occupations at higher risk

Firefighters

Firefighters have shown higher rates of certain types of cancer (respiratory, digestive, and urinary systems), and of all cancers combined, when compared to the general U.S. population. [9] This is linked to many aspects of the firefighting occupation such as exposure to smoke and other products of combustion that are known carcinogens, as well as being exposed to chemicals in the gear worn to protect the firefighter. [10]

Due to the lack of central and comprehensive sources of data, research on cancer rates amongst firefighters has been challenging. [11] [12] [13] [14] On July 7, 2018, Congress passed the Firefighter Cancer Registry Act of 2018 requiring the National Institute for Occupational Safety and Health of the Centers for Disease Control and Prevention to create the National Firefighter Registry designed to collect data on cancer rates among U.S. firefighters. [15] [16] [17]

Construction workers

Construction workers are at a higher risk of developing cancer from exposures at work compared to other occupations. [18] [19] [20]

The increased levels of dust and chemicals like asbestos at construction sites leads to workers being exposed. These long term exposures have been linked to the development of lung cancer. [19] Other factors related to construction work can also put the workers at an elevated risk of cancer such as sun exposure. Construction workers are often required to spend long hours working in the sun. Long periods of exposure to radiation from the sun can cause skin cancer. [20] [21]

Agricultural workers

Agricultural workers face higher rates of cancer development due to exposures on the job. [22]

Similar to construction workers, agricultural workers are exposed too many chemicals including known carcinogens. Workers in the agricultural field are also subject to long periods of exposure to radiation from the sun. All of these factors combine put the workers at and increased risk of developing cancers such as prostate cancer, multiple myeloma, and melanoma of the skin. [22]

Epidemiology

An estimated 48,000 cancers are diagnosed yearly in the US that come from occupational causes; this represents approximately 4-10% of total cancer in the United States. [23] It is estimated that 19% of cancers globally are attributed to environmental exposures (including work-related exposures). [24] It is estimated that there are approximately 120,000 work-related cancer cases annually in the EU due to exposure to carcinogens at work. [25]

Prevention

Many occupational cancers are preventable. Personal protective gear, workplace controls, and worker education can prevent exposure to carcinogens in the workplace. Tobacco smoking has also been shown to increase the risk of work-related cancers; decreasing or abstaining from smoking can decrease cancer risk. [2]

Agencies like the US Food and Drug Administration, Environmental Protection Agency, the International Agency for Research on Cancer (IARC) and Occupational Safety and Health Administration have developed safety standards and limits for chemical and radiation exposure. [2] International Labour Organization has also adopted Occupation Cancer Convention (C139) in 1979 for improvement of workplace safety conditions.

See also

Related Research Articles

<span class="mw-page-title-main">Carcinogen</span> Substance, radionuclide, or radiation directly involved in causing cancer

A carcinogen is any agent that promotes the development of cancer. Carcinogens can include synthetic chemicals, naturally occurring substances, physical agents such as ionizing and non-ionizing radiation, and biologic agents such as viruses and bacteria. Most carcinogens act by creating mutations in DNA that disrupt a cell's normal processes for regulating growth, leading to uncontrolled cellular proliferation. This occurs when the cell's DNA repair processes fail to identify DNA damage allowing the defect to be passed down to daughter cells. The damage accumulates over time. This is typically a multi-step process during which the regulatory mechanisms within the cell are gradually dismantled allowing for unchecked cellular division.

Coal tar is a thick dark liquid which is a by-product of the production of coke and coal gas from coal. It is a type of creosote. It has both medical and industrial uses. Medicinally it is a topical medication applied to skin to treat psoriasis and seborrheic dermatitis (dandruff). It may be used in combination with ultraviolet light therapy. Industrially it is a railroad tie preservative and used in the surfacing of roads. Coal tar was listed as a known human carcinogen in the first Report on Carcinogens from the U.S. Federal Government, issued in 1980.

<span class="mw-page-title-main">Isocyanate</span> Chemical group (–N=C=O)

In organic chemistry, isocyanate is the functional group with the formula R−N=C=O. Organic compounds that contain an isocyanate group are referred to as isocyanates. An organic compound with two isocyanate groups is known as a diisocyanate. Diisocyanates are manufactured for the production of polyurethanes, a class of polymers.

<span class="mw-page-title-main">Firefighter</span> Rescuer trained to extinguish fires and save people

A firefighter is a first responder trained in firefighting, primarily to control and extinguish fires that threaten life and property, as well as to rescue persons from confinement or dangerous situations. Male firefighters are sometimes referred to as firemen.

<span class="mw-page-title-main">Occupational injury</span> Bodily damage resulting from working

An occupational injury is bodily damage resulting from working. The most common organs involved are the spine, hands, the head, lungs, eyes, skeleton, and skin. Occupational injuries can result from exposure to occupational hazards, such as temperature, noise, insect or animal bites, blood-borne pathogens, aerosols, hazardous chemicals, radiation, and occupational burnout.

<span class="mw-page-title-main">Occupational hygiene</span> Management of workplace health hazards

Occupational hygiene is the anticipation, recognition, evaluation, control, and confirmation (ARECC) of protection from risks associated with exposures to hazards in, or arising from, the workplace that may result in injury, illness, impairment, or affect the well-being of workers and members of the community. These hazards or stressors are typically divided into the categories biological, chemical, physical, ergonomic and psychosocial. The risk of a health effect from a given stressor is a function of the hazard multiplied by the exposure to the individual or group. For chemicals, the hazard can be understood by the dose response profile most often based on toxicological studies or models. Occupational hygienists work closely with toxicologists for understanding chemical hazards, physicists for physical hazards, and physicians and microbiologists for biological hazards. Environmental and occupational hygienists are considered experts in exposure science and exposure risk management. Depending on an individual's type of job, a hygienist will apply their exposure science expertise for the protection of workers, consumers and/or communities.

<span class="mw-page-title-main">Chemical hazard</span> Non-biological hazards of hazardous materials

Chemical hazards are hazards present in hazardous chemicals and hazardous materials. Exposure to certain chemicals can cause acute or long-term adverse health effects. Chemical hazards are usually classified separately from biological hazards (biohazards). Chemical hazards are classified into groups that include asphyxiants, corrosives, irritants, sensitizers, carcinogens, mutagens, teratogens, reactants, and flammables. In the workplace, exposure to chemical hazards is a type of occupational hazard. The use of personal protective equipment may substantially reduce the risk of adverse health effects from contact with hazardous materials.

Occupational lung diseases comprise a broad group of diseases, including occupational asthma, industrial bronchitis, chronic obstructive pulmonary disease (COPD), bronchiolitis obliterans, inhalation injury, interstitial lung diseases, infections, lung cancer and mesothelioma. These can be caused directly or due to immunological response to an exposure to a variety of dusts, chemicals, proteins or organisms. Occupational cases of interstitial lung disease may be misdiagnosed as COPD, idiopathic pulmonary fibrosis, or a myriad of other diseases; leading to a delay in identification of the causative agent.

<span class="mw-page-title-main">Occupational hazard</span> Hazard experienced in the workplace

An occupational hazard is a hazard experienced in the workplace. This encompasses many types of hazards, including chemical hazards, biological hazards (biohazards), psychosocial hazards, and physical hazards. In the United States, the National Institute for Occupational Safety and Health (NIOSH) conduct workplace investigations and research addressing workplace health and safety hazards resulting in guidelines. The Occupational Safety and Health Administration (OSHA) establishes enforceable standards to prevent workplace injuries and illnesses. In the EU, a similar role is taken by EU-OSHA.

Workplace health surveillance or occupational health surveillance (U.S.) is the ongoing systematic collection, analysis, and dissemination of exposure and health data on groups of workers. The Joint ILO/WHO Committee on Occupational Health at its 12th Session in 1995 defined an occupational health surveillance system as "a system which includes a functional capacity for data collection, analysis and dissemination linked to occupational health programmes".

<span class="mw-page-title-main">Reproductive toxicity</span> A hazard associated with chemical substances

Reproductive toxicity refers to the potential risk from a given chemical, physical or biologic agent to adversely affect both male and female fertility as well as offspring development. Reproductive toxicants may adversely affect sexual function, ovarian failure, fertility as well as causing developmental toxicity in the offspring. Lowered effective fertility related to reproductive toxicity relates to both male and female effects alike and is reflected in decreased sperm counts, semen quality and ovarian failure.

<span class="mw-page-title-main">Physical hazard</span> Hazard due to a physical agent

A physical hazard is an agent, factor or circumstance that can cause harm with contact. They can be classified as type of occupational hazard or environmental hazard. Physical hazards include ergonomic hazards, radiation, heat and cold stress, vibration hazards, and noise hazards. Engineering controls are often used to mitigate physical hazards.

<span class="mw-page-title-main">Radiation dose reconstruction</span>

Radiation dose reconstruction refers to the process of estimating radiation doses that were received by individuals or populations in the past as a result of particular exposure situations of concern. The basic principle of radiation dose reconstruction is to characterize the radiation environment to which individuals have been exposed using available information. In cases where radiation exposures can not be fully characterized based on available data, default values based on reasonable scientific assumptions can be used as substitutes. The extent to which the default values are used depends on the purpose of the reconstruction(s) being undertaken.

<span class="mw-page-title-main">Occupational safety and health</span> Field concerned with the safety, health and welfare of people at work

Occupational safety and health (OSH) or occupational health and safety (OHS) is a multidisciplinary field concerned with the safety, health, and welfare of people at work. OSH is related to the fields of occupational medicine and occupational hygiene and aligns with workplace health promotion initiatives. OSH also protects all the general public who may be affected by the occupational environment.

Total Worker Health is a trademarked strategy defined as policies, programs, and practices that integrate protection from work-related safety and health hazards with promotion of injury and illness prevention efforts to advance worker well-being. It was conceived and is funded by the National Institute for Occupational Safety and Health (NIOSH). Total Worker Health is tested and developed in six Centers of Excellence for Total Worker Health in the United States.

<span class="mw-page-title-main">Occupational hearing loss</span> Form of hearing loss

Occupational hearing loss (OHL) is hearing loss that occurs as a result of occupational hazards, such as excessive noise and ototoxic chemicals. Noise is a common workplace hazard, and recognized as the risk factor for noise-induced hearing loss and tinnitus but it is not the only risk factor that can result in a work-related hearing loss. Also, noise-induced hearing loss can result from exposures that are not restricted to the occupational setting.

<span class="mw-page-title-main">Agricultural safety and health</span>

Agricultural safety and health is an aspect of occupational safety and health in the agricultural workplace. It specifically addresses the health and safety of farmers, farm workers, and their families.

Occupational cardiovascular diseases (CVD) are diseases of the heart or blood vessels caused by working conditions, making them a form of occupational illness. These diseases include coronary heart disease, stroke, cardiomyopathy, arrythmia, and heart valve or heart chamber problems. Cardiovascular disease is the leading cause of death in the United States and worldwide. In the United States, cardiovascular diseases account for one out of four deaths. The 6th International Conference on Work Environment and Cardiovascular Diseases found that within the working age population about 10-20% of cardiovascular disease deaths can be attributed to work. Ten workplace stressors and risk factors were estimated to be associated with 120,000 U.S. deaths each year and account for 5-8% of health care costs.

There are unique occupational health issues in the casino industry, many of which are attributed to repetitive tasks and long-term exposures to hazards in the casino environment. Among these issues are cancers resulting from exposure to second-hand tobacco smoke, musculoskeletal injury (MSI) from repetitive motion injuries while running table games over many hours, and health issues associated with shift work. Safety and regulatory agencies in the United States have implemented regulatory measures to address the specific risks associated with workers in the casino industry, and have made efforts to identify additional possible risks to casino workers, including noise-induced hearing loss and heavy metal poisoning from exposure to dust from coins.

<span class="mw-page-title-main">National Firefighter Registry for Cancer</span> Registry of firefighters used to evaluate cancer risk

The National Firefighter Registry for Cancer (NFR) is a voluntary registry of firefighters in the United States used to evaluate cancer rates and risk factors in the U.S. fire service through collecting relevant occupational, lifestyle, and health information on firefighters. It aims to use these data to reduce cancer in firefighters.

References

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