A pandemic is an epidemic of an infectious disease that has a sudden increase in cases and spreads across a large region, for instance multiple continents or worldwide, affecting a substantial number of individuals. Widespread endemic diseases with a stable number of infected individuals such as recurrences of seasonal influenza are generally excluded as they occur simultaneously in large regions of the globe rather than being spread worldwide.
An epidemic is the rapid spread of disease to a large number of hosts in a given population within a short period of time. For example, in meningococcal infections, an attack rate in excess of 15 cases per 100,000 people for two consecutive weeks is considered an epidemic.
A cordon sanitaire is the restriction of movement of people into or out of a defined geographic area, such as a community, region, or country. The term originally denoted a barrier used to stop the spread of infectious diseases. The term is also often used metaphorically, in English, to refer to attempts to prevent the spread of an ideology deemed unwanted or dangerous, such as the containment policy adopted by George F. Kennan against the Soviet Union.
In public health, social distancing, also called physical distancing, is a set of non-pharmaceutical interventions or measures intended to prevent the spread of a contagious disease by maintaining a physical distance between people and reducing the number of times people come into close contact with each other. It usually involves keeping a certain distance from others and avoiding gathering together in large groups.
Neil Morris Ferguson is a British epidemiologist and professor of mathematical biology, who specialises in the patterns of spread of infectious disease in humans and animals. He is the director of the Jameel Institute, and of the MRC Centre for Global Infectious Disease Analysis, and head of the Department of Infectious Disease Epidemiology in the School of Public Health and Vice-Dean for Academic Development in the Faculty of Medicine, all at Imperial College London.
Health security is a concept that encompasses activities and measures across sovereign boundaries that mitigates public health incidents to ensure the health of populations. It is an evolving paradigm within the fields of international relations and security studies. Proponents of health security posit that all states have a responsibility to protect the health and wellbeing of their populations. Opponents suggest health security impacts civil liberties and the equal distribution of resources.
Syra Madad is an American pathogen preparedness expert and infectious disease epidemiologist. Madad is the Senior Director of the System-wide Special Pathogens Program at NYC Health + Hospitals where she is part of the executive leadership team which oversees New York City's response to the Coronavirus disease 2019 pandemic in the city's 11 public hospitals. She was featured in the Netflix documentary series Pandemic: How to Prevent an Outbreak and the Discovery Channel documentary The Vaccine: Conquering COVID.
Michael Joseph Ryan is an Irish epidemiologist and former trauma surgeon, specialising in infectious disease and public health. He is executive director of the World Health Organization's Health Emergencies Programme, leading the team responsible for the international containment and treatment of COVID-19. Ryan has held leadership positions and has worked on various outbreak response teams in the field to eradicate the spread of diseases including bacillary dysentery, cholera, Crimean–Congo hemorrhagic fever, Ebola, Marburg virus disease, measles, meningitis, relapsing fever, Rift Valley fever, SARS, and Shigellosis.
Flattening the curve is a public health strategy to slow down the spread of an epidemic, used against the SARS-CoV-2 virus during the early stages of the COVID-19 pandemic. The curve being flattened is the epidemic curve, a visual representation of the number of infected people needing health care over time. During an epidemic, a health care system can break down when the number of people infected exceeds the capability of the health care system's ability to take care of them. Flattening the curve means slowing the spread of the epidemic so that the peak number of people requiring care at a time is reduced, and the health care system does not exceed its capacity. Flattening the curve relies on mitigation techniques such as hand washing, use of face masks and social distancing.
Nahid Bhadelia is an American infectious-diseases physician, founding director of Center for Emerging Infectious Diseases Policy and Research (CEID) at Boston University and an associate professor at the Boston University School of Medicine. She served as the Senior Policy Advisor for Global COVID-19 Response on the White House COVID-19 Response Team.
Caitlin M. Rivers is an American epidemiologist who as Senior Scholar at the Johns Hopkins Center for Health Security and assistant professor at the Johns Hopkins Bloomberg School of Public Health, specializing on improving epidemic preparedness. Rivers is currently working on the American response to the COVID-19 pandemic with a focus on the incorporation of infectious disease modeling and forecasting into public health decision making.
The Imperial College COVID-19 Response Team is a group of experts from Imperial College London studying the COVID-19 pandemic and informing the government of the United Kingdom, and governments and public health agencies around the world. The team comprises scientists from the MRC Centre for Global Infectious Disease Analysis, the Jameel Institute, the Imperial College Business School and the Department of Mathematics. The Imperial College COVID-19 Response Team is led by Professor Neil Ferguson, Director of the Jameel Institute and MRC GIDA.
In epidemiology, a non-pharmaceutical intervention (NPI) is any method used to reduce the spread of an epidemic disease without requiring pharmaceutical drug treatments. Examples of non-pharmaceutical interventions that reduce the spread of infectious diseases include wearing a face mask and staying away from sick people.
The MRC Centre for Global Infectious Disease Analysis is a Medical Research Council funded research centre at Imperial College London and a WHO collaborating centre. It is part of the Department of Infectious Disease Epidemiology at School of Public Health within the Imperial College Faculty of Medicine. Neil Ferguson is the director of the centre, along with four associate directors: Christl Donnelly, Azra Ghani, Nicholas Grassly, and Timothy Hallett. The centre also collaborates UK Health Protection Agency, and the US Centre for Disease Control. The centre's main research areas are disease outbreak analysis and modelling, vaccines, global health analytics, antimicrobial resistance, and developing methods and tools for studying these areas. The centre was previously called the MRC Centre for Outbreak Analysis and Modelling.
Part of managing an infectious disease outbreak is trying to delay and decrease the epidemic peak, known as flattening the epidemic curve. This decreases the risk of health services being overwhelmed and provides more time for vaccines and treatments to be developed. Non-pharmaceutical interventions that may manage the outbreak include personal preventive measures such as hand hygiene, wearing face masks, and self-quarantine; community measures aimed at physical distancing such as closing schools and cancelling mass gathering events; community engagement to encourage acceptance and participation in such interventions; as well as environmental measures such surface cleaning. It has also been suggested that improving ventilation and managing exposure duration can reduce transmission.
Saskia Popescu is an infectious disease epidemiologist and global health security expert in Phoenix, Arizona. She is an Assistant Professor of epidemiology at the University of Maryland, and holds academic appointments at the University of Arizona and George Mason University’s Schar School of Policy and Government, where she lectures on biopreparedness and outbreak response. Since the start of the Coronavirus disease 2019 pandemic, Popescu has worked to prepare for and mitigate the spread of the disease within healthcare and the entertainment industry, where she led the global epidemiology and infection prevention response for Netflix. She has been recognized for her communication efforts around the pandemic, as well as her work on the front lines in infection prevention and healthcare biopreparedness. Popescu currently is a Senior Fellow at the Council on Strategic Risks, addressing converging biological risks from biological weapons nonproliferation, biosecurity, emerging infectious diseases and ecological security, biopreparedness in private industry, and global health security vulnerabilities.
The Abdul Latif Jameel Institute for Disease and Emergency Analytics is a research institute at Imperial College London in the fields of epidemiology, mathematical modelling of infectious diseases and emergencies, environmental health, and health economics. Co-founded in 2019 by Imperial College London and Community Jameel, the Jameel Institute is housed in the School of Public Health, within the college's Faculty of Medicine. The mission of the Jameel Institute is "to combat threats from disease worldwide".
Zero-COVID, also known as COVID-Zero and "Find, Test, Trace, Isolate, and Support" (FTTIS), was a public health policy implemented by some countries, especially China, during the COVID-19 pandemic. In contrast to the "living with COVID-19" strategy, the zero-COVID strategy was purportedly one "of control and maximum suppression". Public health measures used to implement the strategy included as contact tracing, mass testing, border quarantine, lockdowns, and mitigation software in order to stop community transmission of COVID-19 as soon as it was detected. The goal of the strategy was to get the area back to zero new infections and resume normal economic and social activities.
The following outline is provided as an overview of and topical guide to concepts related to infectious diseases in humans.
