PACSIN3

PACSIN3
Identifiers
Aliases	PACSIN3 , SDPIII, protein kinase C and casein kinase substrate in neurons 3
External IDs	OMIM: 606513 MGI: 1891410 HomoloGene: 41117 GeneCards: PACSIN3
Gene location (Human)
Chr.	Chromosome 11 (human)
End	47,186,443 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	91,095,024 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; body of tongue; ; left ventricle; ; Left adrenal gland; ; sural nerve; ; triceps brachii muscle; ; minor salivary gland; ; right lobe of liver; ; body of stomach; ; left uterine tube;
	Top expressed in
	interventricular septum; ; temporal muscle; ; skeletal muscle tissue; ; digastric muscle; ; sternocleidomastoid muscle; ; triceps brachii muscle; ; esophagus; ; soleus muscle; ; lip; ; extraocular muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytoskeletal protein binding ; calcium channel inhibitor activity ; protein binding ; lipid binding ; phospholipid binding ;
Cellular component	endosome ; plasma membrane ; extracellular exosome ; membrane ; cytoplasm ; cytosol ; cytoskeleton ;
Biological process	regulation of endocytosis ; negative regulation of endocytosis ; positive regulation of membrane protein ectodomain proteolysis ; endocytosis ; plasma membrane tubulation ; negative regulation of calcium ion transport ; regulation of molecular function ; cytoskeleton organization ;
	Sources:Amigo / QuickGO
Orthologs
	29763
	80708
	ENSG00000165912
	ENSMUSG00000027257
	Q9UKS6
	Q99JB8
	NM_016223 ; NM_001184974 ; NM_001184975
	NM_001289677 ; NM_001289678 ; NM_028733 ; NM_030880
	NP_001171903 ; NP_001171904 ; NP_057307
	NP_001276606 ; NP_001276607 ; NP_083009 ; NP_112019
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Protein kinase C and casein kinase substrate in neurons protein 3 is an enzyme that in humans is encoded by the PACSIN3 gene.^[5]^[6]

Interactions

PACSIN3 has been shown to interact with PACSIN1 ^[7] and PACSIN2.^[7]

Related Research Articles

C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.

Disintegrin and metalloproteinase domain-containing protein 12 is an enzyme that in humans is encoded by the ADAM12 gene. ADAM12 has two splice variants: ADAM12-L, the long form, has a transmembrane region and ADAM12-S, a shorter variant, is soluble and lacks the transmembrane and cytoplasmic domains.

Disintegrin and metalloproteinase domain-containing protein 15 is an enzyme that in humans is encoded by the ADAM15 gene.

Casein kinase II subunit beta is a protein that in humans is encoded by the CSNK2B gene.

Dynamin-1 is a protein that in humans is encoded by the DNM1 gene.

Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.

PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDC2L1 gene.

Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.

Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.

Sperm-associated antigen 5 is a protein that in humans is encoded by the SPAG5 gene.

Protein kinase C and casein kinase substrate in neurons protein 1 is an enzyme that in humans is encoded by the PACSIN1 gene.

Protein kinase C and casein kinase substrate in neurons protein 2 is a protein that in humans is encoded by the PACSIN2 gene. Pacsin 2 is involved in the formation of caveolae.

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene.

Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.

Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene.

Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000165912 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027257 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Howard L, Nelson KK, Maciewicz RA, Blobel CP (December 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J Biol Chem. 274 (44): 31693–9. doi: 10.1074/jbc.274.44.31693 . PMID 10531379.
↑ "Entrez Gene: PACSIN3 protein kinase C and casein kinase substrate in neurons 3".
1 2 Modregger, J; Ritter B; Witter B; Paulsson M; Plomann M (December 2000). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". J. Cell Sci. 113. ENGLAND. Pt 24 (24): 4511–21. doi:10.1242/jcs.113.24.4511. ISSN 0021-9533. PMID 11082044.

Modregger J, Ritter B, Witter B, et al. (2001). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". J. Cell Sci. 113. Pt 24 (24): 4511–21. doi:10.1242/jcs.113.24.4511. PMID 11082044.
Sumoy L, Pluvinet R, Andreu N, et al. (2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family". Gene. 262 (1–2): 199–205. doi:10.1016/S0378-1119(00)00531-X. PMID 11179684.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Mori S, Tanaka M, Nanba D, et al. (2003). "PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor". J. Biol. Chem. 278 (46): 46029–34. doi: 10.1074/jbc.M306393200 . PMID 12952982.
Schulze WX, Mann M (2004). "A novel proteomic screen for peptide-protein interactions". J. Biol. Chem. 279 (11): 10756–64. doi: 10.1074/jbc.M309909200 . PMID 14679214.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Onodera Y, Hashimoto S, Hashimoto A, et al. (2005). "Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities". EMBO J. 24 (5): 963–73. doi:10.1038/sj.emboj.7600588. PMC 554134 . PMID 15719014.
Cuajungco MP, Grimm C, Oshima K, et al. (2006). "PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4". J. Biol. Chem. 281 (27): 18753–62. doi: 10.1074/jbc.M602452200 . PMID 16627472.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000165912 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027257 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10531379-5] Howard L, Nelson KK, Maciewicz RA, Blobel CP (December 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J Biol Chem. 274 (44): 31693–9. doi: 10.1074/jbc.274.44.31693 . PMID 10531379.

[entrez-6] "Entrez Gene: PACSIN3 protein kinase C and casein kinase substrate in neurons 3".

[pmid11082044-7] 1 2 Modregger, J; Ritter B; Witter B; Paulsson M; Plomann M (December 2000). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". J. Cell Sci. 113. ENGLAND. Pt 24 (24): 4511–21. doi:10.1242/jcs.113.24.4511. ISSN 0021-9533. PMID 11082044.

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PACSIN3

Contents

Interactions

Related Research Articles

References

Further reading