Protein kinase C and casein kinase substrate in neurons protein 2 (Pacsin 2) is a protein that in humans is encoded by the PACSIN2 gene. [5] [6] [7] Pacsin 2 is involved in the formation of caveolae. [8]
The variant rs2413739 in PACSIN2 has been associated with the activity of the enzyme thiopurine-methyltransferase during remission maintenance therapy of children with acute lymphoblastic leukemia and with the incidence of severe gastrointestinal adverse events during remission consolidation therapy of children with acute lymphoblastic leukemia, based mostly on the antimetabolites mercaptopurine and methotrexate. [9]
PACSIN2 has been shown to interact with:
60S ribosomal protein L5 is a protein that in humans is encoded by the RPL5 gene.
Dynamin-1 is a protein that in humans is encoded by the DNM1 gene.
Tyrosine-protein phosphatase non-receptor type 13 is an enzyme that in humans is encoded by the PTPN13 gene.
GRB2-related adapter protein 2 also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 kDa protein that in humans is encoded by the GRAP2 gene.
Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene.
LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene.
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform is an enzyme that in humans is encoded by the PPP2R5D gene. Mutations in PPP2R5D cause Jordan's Syndrome.
Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.
Formin-binding protein 1 is a protein that in humans is encoded by the FNBP1 gene.
Serine/threonine-protein kinase MARK1 is an enzyme that in humans is encoded by the MARK1 gene.
Protein AATF, also known as apoptosis-antagonizing transcription factor is a protein that in humans is encoded by the AATF gene.
Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.
Ubiquitin specific peptidase 5 is an enzyme that in humans is encoded by the USP5 gene.
Multiple PDZ domain protein is a protein that in humans is encoded by the MPDZ gene.
Protein BEX3 is a protein that in humans is encoded by the NGFRAP1 gene.
Collapsin response mediator protein 1, encoded by the CRMP1 gene, is a human protein of the CRMP family.
Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene. It belongs to the eukaryotic translation initiation factor 4E family.
Kappa-casein is a protein that in humans is encoded by the CSN3 gene.
COP9 signalosome complex subunit 7b is a protein that in humans is encoded by the COPS7B gene.
Protein kinase C and casein kinase substrate in neurons protein 3 is an enzyme that in humans is encoded by the PACSIN3 gene.