Protein kinase C and casein kinase substrate in neurons protein 1 is an enzyme that in humans is encoded by the PACSIN1 gene. [5] [6]
This is nonsense.
Please see the scientific literature on Syndapin I in the PubMED database of scientific literature.
PACSIN1 has been shown to interact with GTPases of the Dynamin family (Dynamin 1, 2 and 3). Based on this interaction, its localization and functional role the protein was named syndapin I (synaptic dynamin-associated protein I) - a scientific more useful and more widely used name than PACSIN1.
Subsequently, a variety of further interactions have been published (see PubMED database and search for syndapin I).
In molecular biology, BAR domains are highly conserved protein dimerisation domains that occur in many proteins involved in membrane dynamics in a cell. The BAR domain is banana-shaped and binds to membrane via its concave face. It is capable of sensing membrane curvature by binding preferentially to curved membranes. BAR domains are named after three proteins that they are found in: Bin, Amphiphysin and Rvs.
Amphiphysin is a protein that in humans is encoded by the AMPH gene.
Casein kinase I isoform epsilon is an enzyme that in humans is encoded by the CSNK1E gene.
Casein kinase II subunit alpha' is an enzyme that in humans is encoded by the CSNK2A2 gene.
Dynamin-2 is a protein that in humans is encoded by the DNM2 gene.
Intersectin-1 is a protein that, in humans, is encoded by the ITSN1 gene.
Dynamin-1 is a protein that in humans is encoded by the DNM1 gene.
Neural Wiskott-Aldrich syndrome protein is a protein that in humans is encoded by the WASL gene.
Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.
Formin-binding protein 1 is a protein that in humans is encoded by the FNBP1 gene.
SH3 and multiple ankyrin repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.
Mitogen-activated protein kinase 12 is an enzyme that in humans is encoded by the MAP3K12 gene.
Dynamin-3 is a protein that in humans is encoded by the DNM3 gene. The protein encoded by this gene is a member of the dynamin family which possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding. DNM3 is upregulated in Sézary's syndrome.
Protein kinase C and casein kinase substrate in neurons protein 2 is a protein that in humans is encoded by the PACSIN2 gene. Pacsin 2 is involved in the formation of caveolae.
Protein piccolo is a protein that in humans is encoded by the PCLO gene.
Protein kinase C and casein kinase substrate in neurons protein 3 is an enzyme that in humans is encoded by the PACSIN3 gene.
Activity-regulated cytoskeleton-associated protein is a plasticity protein that in humans is encoded by the ARC gene. It was first characterized in 1995. ARC is a member of the immediate-early gene (IEG) family, a rapidly activated class of genes functionally defined by their ability to be transcribed in the presence of protein synthesis inhibitors. ARC mRNA is localized to activated synaptic sites in an NMDA receptor-dependent manner, where the newly translated protein is believed to play a critical role in learning and memory-related molecular processes. Arc protein is widely considered to be important in neurobiology because of its activity regulation, localization, and utility as a marker for plastic changes in the brain. Dysfunction in the production of Arc protein has been implicated as an important factor in understanding various neurological conditions, including amnesia, Alzheimer's disease, Autism spectrum disorders, and Fragile X syndrome. Along with other IEGs such as ZNF268 and HOMER1, ARC is also a significant tool for systems neuroscience as illustrated by the development of the cellular compartment analysis of temporal activity by fluorescence in situ hybridization, or catFISH technique.
Synapsin II is the collective name for synapsin IIa and synapsin IIb, two nearly identical phosphoproteins in the synapsin family that in humans are encoded by the SYN2 gene. Synapsins associate as endogenous substrates to the surface of synaptic vesicles and act as key modulators in neurotransmitter release across the presynaptic membrane of axonal neurons in the nervous system.
Bulk endocytosis refers to a form of endocytosis of synaptic vesicles at nerve terminals. In bulk endocytosis, compared to clathrin-mediated endocytosis, a larger area of presynaptic plasma membrane is internalised as cisternae or endosomes from which multiple synaptic vesicles can subsequently bud off. Bulk endocytosis is activated specifically during intense stimulation, such as during high-frequency trains of action potentials or in response to membrane depolarization by high extracellular concentrations of potassium.
Syntaphilin is a protein that in humans is encoded by the SNPH gene.
 | This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it. |
