PANK1

PANK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I7N, 3SMP
Identifiers
Aliases	PANK1 , PANK, pantothenate kinase 1
External IDs	OMIM: 606160 MGI: 1922985 HomoloGene: 56979 GeneCards: PANK1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	89,645,242 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	34,856,855 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; liver; ; right lobe of liver; ; renal medulla; ; duodenum; ; rectum; ; vastus lateralis muscle; ; kidney; ; Brodmann area 23; ; ganglionic eminence;
	Top expressed in
	proximal tubule; ; left lobe of liver; ; kidney; ; intercostal muscle; ; submandibular gland; ; soleus muscle; ; ciliary body; ; myocardium of ventricle; ; medullary collecting duct; ; ovary;
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase activity ; ATP binding ; nucleotide binding ; transferase activity ; pantothenate kinase activity ; protein homodimerization activity ; acetyl-CoA binding ;
Cellular component	nucleus ; clathrin coat ; cell periphery ; cytosol ; recycling endosome ; cytoplasm ;
Biological process	coenzyme A biosynthetic process ; phosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	53354
	75735
	ENSG00000152782
	ENSMUSG00000033610
	Q8TE04
	Q8K4K6
	NM_138316 ; NM_148977 ; NM_148978
	NM_001114339 ; NM_023792
	NP_612189 ; NP_683878 ; NP_683879
	NP_001107811 ; NP_076281
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Pantothenate kinase 1 is an enzyme that in humans is encoded by the PANK1 gene.^[5]

This gene encodes a protein belonging to the pantothenate kinase family, which in mammals is made of up PANK1, PANK2 , PANK3, and PANK4 . Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified.^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000152782 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033610 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: PANK1 pantothenate kinase 1".

Robishaw JD, Neely JR (1985). "Coenzyme A metabolism". Am. J. Physiol. 248 (1 Pt 1): E1–9. doi:10.1152/ajpendo.1985.248.1.E1. PMID 2981478.
Hong BS, Senisterra G, Rabeh WM, et al. (2007). "Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder". J. Biol. Chem. 282 (38): 27984–93. doi: 10.1074/jbc.M701915200 . PMID 17631502.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID 15164054.
Ramaswamy G, Karim MA, Murti KG, Jackowski S (2004). "PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression". J. Lipid Res. 45 (1): 17–31. doi: 10.1194/jlr.M300279-JLR200 . PMID 14523052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Westaway SK, Hayflick SJ, Zhou B, Gitschier JD (2003). "In reference to the Short Communication published by Ni et al". Int. J. Biochem. Cell Biol. 34 (12): 1629. doi:10.1016/S1357-2725(02)00125-5. PMID 12379284.
Zhou B, Westaway SK, Levinson B, et al. (2001). "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome". Nat. Genet. 28 (4): 345–9. doi:10.1038/ng572. PMID 11479594. S2CID 20400095.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000152782 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033610 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: PANK1 pantothenate kinase 1".

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PANK1

Related Research Articles

References

Further reading