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Aliases | PANK1 , PANK, pantothenate kinase 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 606160 MGI: 1922985 HomoloGene: 56979 GeneCards: PANK1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Pantothenate kinase 1 is an enzyme that in humans is encoded by the PANK1 gene. [5]
This gene encodes a protein belonging to the pantothenate kinase family, which in mammals is made of up PANK1, PANK2 , PANK3, and PANK4 . Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified. [5]
The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene. ACVR1C is a type I receptor for the TGFB family of signaling molecules.
Pantothenate kinase 2, mitochondrial is an enzyme that in humans is encoded by the PANK2 gene.
Diacylglycerol kinase alpha is an enzyme that in humans is encoded by the DGKA gene.
Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene.
Long-chain-fatty-acid—CoA ligase 5 is an enzyme that in humans is encoded by the ACSL5 gene.
Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene.
Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene. As the name indicates, it is a subunit of mTOR complex 2.
Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene.
MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene. The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases, including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately-spliced transcript variants of this gene encoding distinct isoforms have been reported.
A-kinase anchor protein 6 is an enzyme that in humans is encoded by the AKAP6 gene.
Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.
Serine/threonine-protein kinase 38-like is an enzyme that in humans is encoded by the STK38L gene.
Decaprenyl-diphosphate synthase subunit 1 is an enzyme that in humans is encoded by the PDSS1 gene.
Sphingosine-1-phosphate lyase 1 is an enzyme that in humans is encoded by the SGPL1 gene.
ELAV-like protein 2 is a protein that in humans is encoded by the ELAVL2 gene.
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.
Pantothenate kinase 4 is an enzyme that in humans is encoded by the PANK4 gene.
Docking protein 3 is a protein that in humans is encoded by the DOK3 gene.
Acyl-coenzyme A thioesterase 12 or StAR-related lipid transfer protein 15 (STARD15) is an enzyme that in humans is encoded by the ACOT12 gene. The protein contains a StAR-related lipid transfer domain.
Mps one binder kinase activator-like 1A, also known as Mob1 homolog 1A, is a protein that in humans is encoded by the MOBKL1A gene.