PARD6B

PARD6B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NF3
Identifiers
Aliases	PARD6B , PAR6B, par-6 family cell polarity regulator beta
External IDs	OMIM: 608975 MGI: 2135605 HomoloGene: 23302 GeneCards: PARD6B
Gene location (Human)
Chr.	Chromosome 20 (human)
End	50,756,795 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	167,943,123 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; renal medulla; ; retinal pigment epithelium; ; palpebral conjunctiva; ; amniotic fluid; ; jejunal mucosa; ; lower lobe of lung; ; bronchial epithelial cell; ; corpus epididymis; ; sperm;
	Top expressed in
	secondary oocyte; ; left lung lobe; ; renal corpuscle; ; medullary collecting duct; ; right lung lobe; ; yolk sac; ; jejunum; ; retinal pigment epithelium; ; Epithelium of stomach; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; protein kinase C binding ;
Cellular component	membrane ; bicellular tight junction ; plasma membrane ; apical part of cell ; cell junction ; cell cortex ; extracellular exosome ; nucleus ; cytoplasm ; cytosol ; apical plasma membrane ; protein-containing complex ;
Biological process	regulation of cell migration ; axonogenesis ; cell division ; bicellular tight junction assembly ; cell cycle ; cell-cell junction assembly ; establishment or maintenance of cell polarity ; centrosome cycle ; regulation of cellular localization ; protein-containing complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	84612
	58220
	ENSG00000124171
	ENSMUSG00000044641
	Q9BYG5
	Q9JK83
	NM_032521
	NM_021409
	NP_115910
	NP_067384
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Partitioning defective 6 homolog beta is a protein that in humans is encoded by the PARD6B gene.^[5]^[6]

Function

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.^[6]

Interactions

PARD6B has been shown to interact with:

Related Research Articles

Protein kinase C, zeta (PKCζ), also known as PRKCZ, is a protein in humans that is encoded by the PRKCZ gene. The PRKCZ gene encodes at least two alternative transcripts, the full-length PKCζ and an N-terminal truncated form PKMζ. PKMζ is thought to be responsible for maintaining long-term memories in the brain. The importance of PKCζ in the creation and maintenance of long-term potentiation was first described by Todd Sacktor and his colleagues at the SUNY Downstate Medical Center in 1993.

<span class="mw-page-title-main">CDC42</span> Protein-coding gene in the species Homo sapiens

Cell division control protein 42 homolog, also known as Cdc42, is a protein involved in regulation of the cell cycle. It was originally identified in S. cerevisiae (yeast) as a mediator of cell division, and is now known to influence a variety of signaling events and cellular processes in a variety of organisms from yeast to mammals.

Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene.

Serine/threonine-protein kinase MARK2 is an enzyme that in humans is encoded by the MARK2 gene.

Partitioning defective 6 homolog alpha is a protein that in humans is encoded by the PARD6A gene.

Protein ECT2 is a protein that in humans is encoded by the ECT2 gene.

Rho-related GTP-binding protein RhoQ is a protein that in humans is encoded by the RHOQ gene.

Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.

MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene.

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.

Septin-7 is a protein that in humans is encoded by the SEPT7 gene.

60S ribosomal protein L12 is a protein that in humans is encoded by the RPL12 gene.

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.

G-protein-signaling modulator 1 is a protein that in humans is encoded by the GPSM1 gene.

G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2 gene.

Calcium-binding protein 39 is a protein that in humans is encoded by the CAB39 gene.

MAP/microtubule affinity-regulating kinase 4 is an enzyme that in humans is encoded by the MARK4 gene. MARK4 belongs to the family of serine/threonine kinases that phosphorylate microtubule-associated proteins (MAP) causing their detachment from microtubules. Detachment thereby increases microtubule dynamics and facilitates a number of cell activities including cell division, cell cycle control, cell polarity determination, and cell shape alterations.

Cdc42 effector protein 4 is a protein that in humans is encoded by the CDC42EP4 gene.

Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.

Partitioning defective 3 homolog B is a protein that in humans is encoded by the PARD3B gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124171 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044641 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 4 Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (March 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells. 6 (2): 107–19. doi: 10.1046/j.1365-2443.2001.00404.x . PMID 11260256. S2CID 8789941.
1 2 "Entrez Gene: PARD6B par-6 partitioning defective 6 homolog beta (C. elegans)".
1 2 Neudauer CL, Joberty G, Macara IG (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552.
1 2 Joberty G, Petersen C, Gao L, Macara IG (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.

Joberty G, Petersen C, Gao L, Macara IG (2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.
Gao L, Macara IG, Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties". Gene. 294 (1–2): 99–107. doi:10.1016/S0378-1119(02)00681-9. PMID 12234671.
Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (2003). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187.
Hurd TW, Gao L, Roh MH, Macara IG, Margolis B (2003). "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly". Nat. Cell Biol. 5 (2): 137–42. doi:10.1038/ncb923. PMID 12545177. S2CID 25212419.
Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, Iwamatsu A, Shinohara A, Ohno S (2004). "Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity". Curr. Biol. 13 (9): 734–43. doi: 10.1016/S0960-9822(03)00244-6 . PMID 12725730. S2CID 18570360.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi: 10.1074/jbc.M312171200 . PMID 14676191.
Labhart P, Karmakar S, Salicru EM, Egan BS, Alexiadis V, O'Malley BW, Smith CL (2005). "Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1339–44. Bibcode:2005PNAS..102.1339L. doi: 10.1073/pnas.0409578102 . PMC 547886 . PMID 15677324.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124171 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044641 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11260256-5] 1 2 3 4 Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (March 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells. 6 (2): 107–19. doi: 10.1046/j.1365-2443.2001.00404.x . PMID 11260256. S2CID 8789941.

[entrez-6] 1 2 "Entrez Gene: PARD6B par-6 partitioning defective 6 homolog beta (C. elegans)".

[pmid11162552-7] 1 2 Neudauer CL, Joberty G, Macara IG (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552.

[pmid10934474-8] 1 2 Joberty G, Petersen C, Gao L, Macara IG (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.

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PARD6B

Contents

Function

Interactions

Related Research Articles

References

Further reading