PARD6B

PARD6B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NF3
Identifiers
Aliases	PARD6B , PAR6B, par-6 family cell polarity regulator beta
External IDs	OMIM: 608975; MGI: 2135605; HomoloGene: 23302; GeneCards: PARD6B; OMA:PARD6B - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.13 Start 50,731,580 bp [1] End 50,756,795 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H3 Start 167,922,924 bp [2] End 167,943,123 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium renal medulla retinal pigment epithelium palpebral conjunctiva epithelium of nasopharynx amniotic fluid jejunal mucosa lower lobe of lung mucosa of paranasal sinus bronchial epithelial cell Top expressed in secondary oocyte zygote primary oocyte left lung lobe renal corpuscle medullary collecting duct right kidney right lung lobe yolk sac epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase C binding Cellular component membrane bicellular tight junction plasma membrane apical part of cell cell junction cell cortex extracellular exosome nucleus cytoplasm cytosol apical plasma membrane protein-containing complex Biological process regulation of cell migration axonogenesis cell division bicellular tight junction assembly cell cycle cell-cell junction assembly establishment or maintenance of cell polarity centrosome cycle regulation of cellular localization protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84612 58220 Ensembl ENSG00000124171 ENSMUSG00000044641 UniProt Q9BYG5 Q9JK83 RefSeq (mRNA) NM_032521 NM_021409 RefSeq (protein) NP_115910 NP_067384 Location (UCSC) Chr 20: 50.73 – 50.76 Mb Chr 2: 167.92 – 167.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Partitioning defective 6 homolog beta is a protein that in humans is encoded by the PARD6B gene. ^{[5] [6]}

Function

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. ^[6]

Interactions

PARD6B has been shown to interact with:

• CDC42, ^{[5] [7] [8]}
• Protein kinase Mζ, ^[5]
• RAC1, ^[5] and
• RHOQ. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000124171 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044641 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (March 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells. 6 (2): 107–19. doi: 10.1046/j.1365-2443.2001.00404.x . PMID   11260256. S2CID   8789941.
6. "Entrez Gene: PARD6B par-6 partitioning defective 6 homolog beta (C. elegans)".
7. Neudauer CL, Joberty G, Macara IG (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID   11162552.
8. Joberty G, Petersen C, Gao L, Macara IG (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID   10934474. S2CID   27139234.

Further reading

• Joberty G, Petersen C, Gao L, Macara IG (2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID   10934474. S2CID   27139234.
• Gao L, Macara IG, Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties". Gene. 294 (1–2): 99–107. doi:10.1016/S0378-1119(02)00681-9. PMID   12234671.
• Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (2003). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID   12459187.
• Hurd TW, Gao L, Roh MH, Macara IG, Margolis B (2003). "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly". Nat. Cell Biol. 5 (2): 137–42. doi:10.1038/ncb923. PMID   12545177. S2CID   25212419.
• Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, Iwamatsu A, Shinohara A, Ohno S (2004). "Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity". Curr. Biol. 13 (9): 734–43. doi: 10.1016/S0960-9822(03)00244-6 . PMID   12725730. S2CID   18570360.
• Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi: 10.1074/jbc.M312171200 . PMID   14676191.
• Labhart P, Karmakar S, Salicru EM, Egan BS, Alexiadis V, O'Malley BW, Smith CL (2005). "Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1339–44. Bibcode:2005PNAS..102.1339L. doi: 10.1073/pnas.0409578102 . PMC   547886 . PMID   15677324.