PARVB

PARVB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4EDL, 4EDM, 4EDN
Identifiers
Aliases	PARVB , CGI-56, parvin beta
External IDs	OMIM: 608121; MGI: 2153063; HomoloGene: 8342; GeneCards: PARVB; OMA:PARVB - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.31 Start 43,999,211 bp [1] End 44,172,939 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E2 Start 84,116,244 bp [2] End 84,199,889 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle apex of heart monocyte left ventricle right auricle of heart islet of Langerhans right lung right adrenal gland upper lobe of left lung Top expressed in blood lumbar spinal ganglion muscle of thigh molar right lobe of liver extraocular muscle soleus muscle digastric muscle atrium yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding Cellular component cytoplasm cytosol cell junction plasma membrane cell projection sarcomere Z discdkac cytoskeleton membrane focal adhesion lamellipodium actin cytoskeleton Biological process actin cytoskeleton reorganization cell adhesion cell projection assembly lamellipodium assembly establishment or maintenance of cell polarity regulating cell shape establishment or maintenance of cell polarity substrate adhesion-dependent cell spreading Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29780 170736 Ensembl ENSG00000188677 ENSMUSG00000022438 UniProt Q9HBI1 Q9ES46 RefSeq (mRNA) NM_001003828 NM_001243385 NM_001243386 NM_013327 NM_133167 RefSeq (protein) NP_001003828 NP_001230314 NP_001230315 NP_037459 NP_573395 Location (UCSC) Chr 22: 44 – 44.17 Mb Chr 15: 84.12 – 84.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Beta-parvin is a protein that in humans is encoded by the PARVB gene. ^{[5] [6] [7]}

Members of the parvin family, including PARVB, PARVA and PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM] ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000188677 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022438 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC   310876 . PMID   10810093.
6. Olski TM, Noegel AA, Korenbaum E (Feb 2001). "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily". J Cell Sci. 114 (Pt 3): 525–38. doi:10.1242/jcs.114.3.525. PMID   11171322.
7. "Entrez Gene: PARVB parvin, beta".

Further reading

• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Yamaji S, Suzuki A, Sugiyama Y, et al. (2001). "A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction". J. Cell Biol. 153 (6): 1251–64. doi:10.1083/jcb.153.6.1251. PMC   2192033 . PMID   11402068.
• Korenbaum E, Olski TM, Noegel AA (2002). "Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans". Gene. 279 (1): 69–79. doi:10.1016/S0378-1119(01)00743-0. PMID   11722847.
• Yamaji S, Suzuki A, Kanamori H, et al. (2002). "Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation". Biochem. Biophys. Res. Commun. 297 (5): 1324–31. doi:10.1016/S0006-291X(02)02381-1. PMID   12372433.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Rosenberger G, Jantke I, Gal A, Kutsche K (2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling". Hum. Mol. Genet. 12 (2): 155–67. doi: 10.1093/hmg/ddg019 . PMID   12499396.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC   430954 . PMID   12529303.
• Mishima W, Suzuki A, Yamaji S, et al. (2004). "The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor". Genes Cells. 9 (3): 193–204. doi: 10.1111/j.1356-9597.2004.00717.x . PMID   15005707.
• Yamaji S, Suzuki A, Kanamori H, et al. (2004). "Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction". J. Cell Biol. 165 (4): 539–51. doi:10.1083/jcb.200308141. PMC   2172344 . PMID   15159419.
• Zhang Y, Chen K, Tu Y, Wu C (2004). "Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival". J. Biol. Chem. 279 (40): 41695–705. doi: 10.1074/jbc.M401563200 . PMID   15284246.
• Mongroo PS, Johnstone CN, Naruszewicz I, et al. (2004). "Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer". Oncogene. 23 (55): 8959–70. doi: 10.1038/sj.onc.1208112 . PMID   15467740.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Matsuda C, Kameyama K, Tagawa K, et al. (2005). "Dysferlin interacts with affixin (beta-parvin) at the sarcolemma". J. Neuropathol. Exp. Neurol. 64 (4): 334–40. doi: 10.1093/jnen/64.4.334 . PMID   15835269.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.