PARVB

PARVB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4EDL, 4EDM, 4EDN
Identifiers
Aliases	PARVB , CGI-56, parvin beta
External IDs	OMIM: 608121 MGI: 2153063 HomoloGene: 8342 GeneCards: PARVB
Gene location (Human)
Chr.	Chromosome 22 (human)
End	44,172,939 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	84,199,889 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; monocyte; ; left ventricle; ; islet of Langerhans; ; right lung; ; Right adrenal gland; ; upper lobe of left lung; ; Left adrenal gland; ; sural nerve; ; skeletal muscle tissue;
	Top expressed in
	blood; ; molar; ; right lobe of liver; ; extraocular muscle; ; soleus muscle; ; digastric muscle; ; atrium; ; yolk sac; ; myocardium of ventricle; ; left ventricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	actin binding ; protein binding ;
Cellular component	cytoplasm ; cytosol ; cell junction ; plasma membrane ; cell projection ; sarcomere ; Z disc ; cytoskeleton ; membrane ; focal adhesion ; lamellipodium ; actin cytoskeleton ;
Biological process	actin cytoskeleton reorganization ; cell adhesion ; cell projection assembly ; lamellipodium assembly ; establishment or maintenance of cell polarity regulating cell shape ; establishment or maintenance of cell polarity ; substrate adhesion-dependent cell spreading ;
	Sources:Amigo / QuickGO
Orthologs
	29780
	170736
	ENSG00000188677
	ENSMUSG00000022438
	Q9HBI1
	Q9ES46
	NM_001003828 ; NM_001243385 ; NM_001243386 ; NM_013327
	NM_133167
	NP_001003828 ; NP_001230314 ; NP_001230315 ; NP_037459
	NP_573395
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Beta-parvin is a protein that in humans is encoded by the PARVB gene.^[5]^[6]^[7]

Members of the parvin family, including PARVB, PARVA and PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000188677 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022438 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876 . PMID 10810093.
↑ Olski TM, Noegel AA, Korenbaum E (Feb 2001). "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily". J Cell Sci. 114 (Pt 3): 525–38. doi:10.1242/jcs.114.3.525. PMID 11171322.
1 2 "Entrez Gene: PARVB parvin, beta".

Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
Yamaji S, Suzuki A, Sugiyama Y, et al. (2001). "A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction". J. Cell Biol. 153 (6): 1251–64. doi:10.1083/jcb.153.6.1251. PMC 2192033 . PMID 11402068.
Korenbaum E, Olski TM, Noegel AA (2002). "Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans". Gene. 279 (1): 69–79. doi:10.1016/S0378-1119(01)00743-0. PMID 11722847.
Yamaji S, Suzuki A, Kanamori H, et al. (2002). "Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation". Biochem. Biophys. Res. Commun. 297 (5): 1324–31. doi:10.1016/S0006-291X(02)02381-1. PMID 12372433.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Rosenberger G, Jantke I, Gal A, Kutsche K (2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling". Hum. Mol. Genet. 12 (2): 155–67. doi: 10.1093/hmg/ddg019 . PMID 12499396.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954 . PMID 12529303.
Mishima W, Suzuki A, Yamaji S, et al. (2004). "The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor". Genes Cells. 9 (3): 193–204. doi: 10.1111/j.1356-9597.2004.00717.x . PMID 15005707.
Yamaji S, Suzuki A, Kanamori H, et al. (2004). "Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction". J. Cell Biol. 165 (4): 539–51. doi:10.1083/jcb.200308141. PMC 2172344 . PMID 15159419.
Zhang Y, Chen K, Tu Y, Wu C (2004). "Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival". J. Biol. Chem. 279 (40): 41695–705. doi: 10.1074/jbc.M401563200 . PMID 15284246.
Mongroo PS, Johnstone CN, Naruszewicz I, et al. (2004). "Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer". Oncogene. 23 (55): 8959–70. doi: 10.1038/sj.onc.1208112 . PMID 15467740.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Matsuda C, Kameyama K, Tagawa K, et al. (2005). "Dysferlin interacts with affixin (beta-parvin) at the sarcolemma". J. Neuropathol. Exp. Neurol. 64 (4): 334–40. doi: 10.1093/jnen/64.4.334 . PMID 15835269.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000188677 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022438 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10810093-5] Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876 . PMID 10810093.

[pmid11171322-6] Olski TM, Noegel AA, Korenbaum E (Feb 2001). "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily". J Cell Sci. 114 (Pt 3): 525–38. doi:10.1242/jcs.114.3.525. PMID 11171322.

[entrez-7] 1 2 "Entrez Gene: PARVB parvin, beta".

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PARVB

Related Research Articles

References

Further reading