PARVG

PARVG
Identifiers
Aliases	PARVG , parvin gamma
External IDs	OMIM: 608122; MGI: 2158329; HomoloGene: 11151; GeneCards: PARVG; OMA:PARVG - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.31 Start 44,172,956 bp [1] End 44,219,533 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E2 Start 84,208,227 bp [2] End 84,227,179 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte spleen blood appendix lymph node bone marrow bone marrow cells upper lobe of left lung right lung Top expressed in granulocyte thymus spleen tibiofemoral joint mesenteric lymph nodes bone marrow dentate gyrus of hippocampal formation granule cell spermatid blood lumbar subsegment of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function actin binding protein binding Cellular component cytoplasm cell junction plasma membrane cytoskeleton membrane focal adhesion actin cytoskeleton Biological process actin cytoskeleton reorganization cell-matrix adhesion cell adhesion establishment or maintenance of cell polarity cell projection assembly substrate adhesion-dependent cell spreading Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64098 64099 Ensembl ENSG00000138964 ENSMUSG00000022439 UniProt Q9HBI0 Q9ERD8 RefSeq (mRNA) NM_001137605 NM_001137606 NM_001254741 NM_001254742 NM_001254743 NM_022141 NM_001162500 NM_022321 RefSeq (protein) NP_001131077 NP_071424 NP_001155972 NP_071716 Location (UCSC) Chr 22: 44.17 – 44.22 Mb Chr 15: 84.21 – 84.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Gamma-parvin is a protein that in humans is encoded by the PARVG gene. ^{[5] [6]}

Members of the parvin family, including PARVG, PARVA and PARVB, are actin-binding proteins associated with focal contacts.[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000138964 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022439 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Olski TM, Noegel AA, Korenbaum E (Feb 2001). "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily". J Cell Sci. 114 (Pt 3): 525–38. doi:10.1242/jcs.114.3.525. PMID   11171322.
6. "Entrez Gene: PARVG parvin, gamma".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22" (PDF). Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Korenbaum E, Olski TM, Noegel AA (2002). "Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans". Gene. 279 (1): 69–79. doi:10.1016/S0378-1119(01)00743-0. PMID   11722847.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC   430954 . PMID   12529303.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Alonso ME, Bello MJ, de Campos JM, et al. (2005). "No evidence of INI1hSNF5 (SMARCB1) and PARVG point mutations in oligodendroglial neoplasms". Cancer Genet. Cytogenet. 160 (2): 169–73. doi:10.1016/j.cancergencyto.2004.12.020. PMID   15993274.
• Yoshimi R, Yamaji S, Suzuki A, et al. (2006). "The gamma-parvin-integrin-linked kinase complex is critically involved in leukocyte-substrate interaction". J. Immunol. 176 (6): 3611–24. doi: 10.4049/jimmunol.176.6.3611 . PMID   16517730.