PCBP3

PCBP3
Identifiers
Aliases	PCBP3 , ALPHA-CP3, poly(rC) binding protein 3
External IDs	OMIM: 608502; MGI: 1890470; HomoloGene: 23233; GeneCards: PCBP3; OMA:PCBP3 - orthologs
Gene location (Mouse) Chr. Chromosome 10 (mouse) [1] Band 10|10 C1 Start 76,597,691 bp [1] End 76,797,721 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in neural layer of retina trigeminal ganglion seminiferous tubule external carotid artery spermatocyte olfactory bulb retinal pigment epithelium spermatid Rostral migratory stream lumbar spinal ganglion BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleic acid binding DNA-binding transcription repressor activity, RNA polymerase II-specific double-stranded DNA binding C-rich single-stranded DNA binding RNA binding Cellular component cytoplasm cytosol extracellular exosome nucleus Biological process mRNA metabolic process negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54039 59093 Ensembl ENSG00000183570 ENSMUSG00000001120 UniProt P57721 P57722 RefSeq (mRNA) NM_020528 NM_001130141 NM_021568 NM_001347216 RefSeq (protein) NP_001123613 NP_065389 NP_001335167 NP_001335168 NP_001335169 NP_001335170 NP_001335171 NP_001335172 NP_001335173 NP_001335174 NP_001369205 NP_001369206 NP_001369207 NP_001369208 NP_001369210 NP_001369211 NP_001369212 NP_001369213 NP_001369214 NP_001369215 NP_001369216 NP_001369217 NP_001371085 NP_001334145 NP_067543 Location (UCSC) n/a Chr 10: 76.6 – 76.8 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Poly(rC)-binding protein 3 is a protein that in humans is encoded by the PCBP3 gene. ^{[4] [5]}

This gene encodes a member of the KH domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple polyadenylation sites exist for this gene. ^[5]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000001120 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Makeyev AV, Liebhaber SA (Sep 2000). "Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins". Genomics. 67 (3): 301–16. doi:10.1006/geno.2000.6244. PMID   10936052.
5. "Entrez Gene: PCBP3 poly(rC) binding protein 3".

Further reading

• Makeyev AV, Liebhaber SA (2002). "The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms". RNA. 8 (3) S1355838202024627: 265–78. doi:10.1017/S1355838202024627. PMC   1370249 . PMID   12003487.
• Kiledjian M, Wang X, Liebhaber SA (1995). "Identification of two KH domain proteins in the alpha-globin mRNP stability complex". EMBO J. 14 (17): 4357–64. doi:10.1002/j.1460-2075.1995.tb00110.x. PMC   394520 . PMID   7556077.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID   10830953.
• Makeyev AV, Eastmond DL, Liebhaber SA (2002). "Targeting a KH-domain protein with RNA decoys". RNA. 8 (9) S135583820202808X: 1160–73. doi:10.1017/S135583820202808X. PMC   1370330 . PMID   12358435.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Chkheidze AN, Liebhaber SA (2003). "A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins". Mol. Cell. Biol. 23 (23): 8405–15. doi:10.1128/MCB.23.23.8405-8415.2003. PMC   262676 . PMID   14612387.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7 155. doi: 10.1186/1471-2164-7-155 . PMC   1526728 . PMID   16780588.