PCDH10

PCDH10
Identifiers
Aliases	PCDH10 , OL-PCDH, PCDH19, protocadherin 10
External IDs	OMIM: 608286; MGI: 1338042; HomoloGene: 74967; GeneCards: PCDH10; OMA:PCDH10 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q28.3 Start 133,149,294 bp [1] End 133,208,606 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 B Start 45,332,833 bp [2] End 45,390,058 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell prefrontal cortex internal globus pallidus Brodmann area 46 caudate nucleus nucleus accumbens superior frontal gyrus Brodmann area 23 stromal cell of endometrium putamen Top expressed in substantia nigra olfactory tubercle lateral hypothalamus globus pallidus dorsomedial hypothalamic nucleus primary motor cortex superior frontal gyrus paraventricular nucleus of hypothalamus nucleus accumbens medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process homophilic cell adhesion via plasma membrane adhesion molecules cell adhesion cell-cell signaling nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57575 18526 Ensembl ENSG00000138650 ENSMUSG00000049100 UniProt Q9P2E7 n/a RefSeq (mRNA) NM_020815 NM_032961 NM_001098170 NM_001098171 NM_001098172 NM_011043 RefSeq (protein) NP_065866 NP_116586 n/a Location (UCSC) Chr 4: 133.15 – 133.21 Mb Chr 3: 45.33 – 45.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin-10 is a protein that in humans is encoded by the PCDH10 gene. ^{[5] [6]}

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The mRNA encodes a cadherin-related neuronal receptor thought to play a role in the establishment and function of specific cell-cell connections in the brain. This family member contains 6 extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. Alternatively spliced transcripts encode isoforms with unique cytoplasmic domains. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000138650 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049100 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID   10835267.
6. "Entrez Gene: PCDH10 protocadherin 10".

Further reading

• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi: 10.1101/gad.14.10.1169 . PMID   10817752. S2CID   44844497.
• Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID   8012384. S2CID   12847618.
• Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi: 10.1016/S0092-8674(00)80789-8 . PMID   10380929. S2CID   6014717.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi: 10.1073/pnas.060027397 . PMC   16203 . PMID   10716726.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID   10718198.
• Wu Q, Zhang T, Cheng JF, et al. (2001). "Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters". Genome Res. 11 (3): 389–404. doi:10.1101/gr.167301. PMC   311048 . PMID   11230163.
• Wolverton T, Lalande M (2001). "Identification and characterization of three members of a novel subclass of protocadherins". Genomics. 76 (1–3): 66–72. doi:10.1006/geno.2001.6592. PMID   11549318.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ying J, Li H, Seng TJ, et al. (2006). "Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation". Oncogene. 25 (7): 1070–80. doi:10.1038/sj.onc.1209154. PMID   16247458. S2CID   11573872.