PCGF6

PCGF6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DJB
Identifiers
Aliases	PCGF6 , MBLR, RNF134, polycomb group ring finger 6
External IDs	OMIM: 607816 MGI: 1918291 HomoloGene: 12378 GeneCards: PCGF6
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.33 Start 103,302,796 bp [1] End 103,351,144 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 C3 Start 47,022,056 bp [2] End 47,039,345 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle skeletal muscle tissue stromal cell of endometrium smooth muscle tissue ganglionic eminence right lobe of liver gastric mucosa myometrium subcutaneous adipose tissue Achilles tendon Top expressed in spermatocyte secondary oocyte seminiferous tubule primitive streak spermatid Paneth cell superior cervical ganglion somite medullary collecting duct submandibular gland More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein binding DNA-binding transcription repressor activity, RNA polymerase II-specific metal ion binding Cellular component nucleus PcG protein complex nucleoplasm PRC1 complex Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated histone H2A-K119 monoubiquitination negative regulation of G0 to G1 transition negative regulation of transcription, DNA-templated inactivation of X chromosome by genetic imprinting Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84108 71041 Ensembl ENSG00000156374 ENSMUSG00000025050 UniProt Q9BYE7 Q99NA9 RefSeq (mRNA) NM_001011663 NM_032154 NM_027654 NM_001360632 RefSeq (protein) NP_001011663 NP_115530 NP_081930 NP_001347561 Location (UCSC) Chr 10: 103.3 – 103.35 Mb Chr 19: 47.02 – 47.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Polycomb group RING finger protein 6 is a protein that in humans is encoded by the PCGF6 gene. ^{[5] [6]}

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000156374 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025050 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H (Aug 2002). "MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation" (PDF). Genes Cells. 7 (8): 835–50. doi:10.1046/j.1365-2443.2002.00565.x. hdl: 2027.42/72663 . PMID   12167161. S2CID   23060582.
6. "Entrez Gene: PCGF6 polycomb group ring finger 6".

Further reading

• Kanno M, Hasegawa M, Ishida A, et al. (1996). "mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity". EMBO J. 14 (22): 5672–8. doi:10.1002/j.1460-2075.1995.tb00254.x. PMC   394682 . PMID   8521824.
• Trimarchi JM, Fairchild B, Wen J, Lees JA (2001). "The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1519–24. doi: 10.1073/pnas.041597698 . PMC   29289 . PMID   11171983.
• Suzuki M, Mizutani-Koseki Y, Fujimura Y, et al. (2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice". Development. 129 (18): 4171–83. doi:10.1242/dev.129.18.4171. PMID   12183370.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Zhong N, Radu G, Ju W, Brown WT (2006). "Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C". Biochem. Biophys. Res. Commun. 338 (2): 855–61. doi:10.1016/j.bbrc.2005.10.020. PMID   16248985.
• Lee MG, Norman J, Shilatifard A, Shiekhattar R (2007). "Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein". Cell. 128 (5): 877–87. doi: 10.1016/j.cell.2007.02.004 . PMID   17320162. S2CID   6519228.