PDE4C

PDE4C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QYM
Identifiers
Aliases	PDE4C , DPDE1, phosphodiesterase 4C, PDE21
External IDs	OMIM: 600128; MGI: 99556; HomoloGene: 20256; GeneCards: PDE4C; OMA:PDE4C - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.11 Start 18,208,652 bp [1] End 18,248,200 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 B3.3|8 34.15 cM Start 71,176,369 bp [2] End 71,203,835 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh tibial arteries spleen skeletal muscle tissue gastrocnemius muscle left ventricle testicle muscle layer of sigmoid colon stromal cell of endometrium Top expressed in renal cortex proximal tubule human kidney right kidney islet of Langerhans hepatobiliary system liver muscle of thigh muscle tissue duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoric diester hydrolase activity protein binding 3',5'-cyclic-nucleotide phosphodiesterase activity hydrolase activity metal ion binding 3',5'-cyclic-AMP phosphodiesterase activity Cellular component cytosol cell projection extracellular space cilium Biological process cAMP catabolic process signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5143 110385 Ensembl ENSG00000105650 ENSMUSG00000031842 UniProt Q08493 Q3UEI1 RefSeq (mRNA) NM_000923 NM_001098818 NM_001098819 NM_001330172 NM_001369701 NM_001395274 NM_201607 NM_001310465 RefSeq (protein) NP_000914 NP_001092288 NP_001092289 NP_001317101 NP_001356630 NP_001297394 NP_963901 Location (UCSC) Chr 19: 18.21 – 18.25 Mb Chr 8: 71.18 – 71.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

cAMP-specific 3',5'-cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene. ^[5]

Tissue localisation

PDE4C is predominantly found in peripheral tissues. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000105650 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031842 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)".
6. Zhang, HT (2009). "Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs". Current Pharmaceutical Design. 15 (14): 1688–1698. doi:10.2174/138161209788168092. PMID   19442182.

Further reading

• Engels P, Sullivan M, Müller T, Lübbert H (1995). "Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C)". FEBS Lett. 358 (3): 305–10. doi: 10.1016/0014-5793(94)01460-I . PMID   7843419. S2CID   24276391.
• Milatovich A, Bolger G, Michaeli T, Francke U (1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somat. Cell Mol. Genet. 20 (2): 75–86. doi:10.1007/BF02290677. PMID   8009369. S2CID   19182571.
• Bolger G, Michaeli T, Martins T, et al. (1993). "A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs". Mol. Cell. Biol. 13 (10): 6558–71. doi:10.1128/mcb.13.10.6558. PMC   364715 . PMID   8413254.
• Obernolte R, Ratzliff J, Baecker PA, et al. (1997). "Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis". Biochim. Biophys. Acta. 1353 (3): 287–97. doi:10.1016/s0167-4781(97)00080-8. PMID   9349724.
• Owens RJ, Lumb S, Rees-Milton K, et al. (1998). "Molecular cloning and expression of a human phosphodiesterase 4C". Cell. Signal. 9 (8): 575–85. doi:10.1016/S0898-6568(97)00072-7. PMID   9429761.
• Sullivan M, Olsen AS, Houslay MD (2000). "Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND". Cell. Signal. 11 (10): 735–42. doi:10.1016/S0898-6568(99)00037-6. PMID   10574328.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi: 10.1096/fj.00-0354com . PMID   11156964. S2CID   26315564.
• Pérez-Torres S, Miró X, Palacios JM, et al. (2001). "Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain". J. Chem. Neuroanat. 20 (3–4): 349–74. doi:10.1016/S0891-0618(00)00097-1. hdl: 10261/112708 . PMID   11207431. S2CID   25012736.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Johnson JM, Castle J, Garrett-Engele P, et al. (2004). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science. 302 (5653): 2141–4. doi:10.1126/science.1090100. PMID   14684825. S2CID   10007258.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID   15057824.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.

External links

• Overview of all the structural information available in the PDB for UniProt : Q08493 (cAMP-specific 3',5'-cyclic phosphodiesterase 4C) at the PDBe-KB .