PDE4C

Last updated
PDE4C
Protein PDE4C PDB 1LXU.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PDE4C , DPDE1, phosphodiesterase 4C, PDE21
External IDs OMIM: 600128 MGI: 99556 HomoloGene: 20256 GeneCards: PDE4C
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_201607
NM_001310465

RefSeq (protein)

NP_000914
NP_001092288
NP_001092289
NP_001317101
NP_001356630

Contents

NP_001297394
NP_963901

Location (UCSC) Chr 19: 18.21 – 18.25 Mb Chr 8: 71.18 – 71.2 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

cAMP-specific 3',5'-cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene. [5]


Tissue localisation

PDE4C is predominantly found in peripheral tissues. [6]

Related Research Articles

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cAMP-specific 3',5'-cyclic phosphodiesterase 4A is an enzyme that in humans is encoded by the PDE4A gene.

<span class="mw-page-title-main">PDE4B</span> Protein-coding gene in the species Homo sapiens

cAMP-specific 3',5'-cyclic phosphodiesterase 4B is an enzyme that in humans is encoded by the PDE4B gene.

<span class="mw-page-title-main">PDE11A</span> Protein-coding gene in the species Homo sapiens

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.

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Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.

<span class="mw-page-title-main">ADCY9</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PDE1A</span> Protein-coding gene in the species Homo sapiens

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A is an enzyme that in humans is encoded by the PDE1A gene.

<span class="mw-page-title-main">PDE7A</span> Protein-coding gene in the species Homo sapiens

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A is an enzyme that in humans is encoded by the PDE7A gene. Mammals possess 21 cyclic nucleotide phosphodiesterase (PDE) genes that are pharmacologically grouped into 11 families. PDE7A is one of two genes in the PDE7 family, the other being PDE7B. The PDE7 family, along with the PDE4 and PDE8 families, are cAMP-specific, showing little to no activity against 3', 5'-cyclic guanosine monophosphate (cGMP).

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<span class="mw-page-title-main">PDE9A</span> Protein-coding gene in the species Homo sapiens

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A is an enzyme that in humans is encoded by the PDE9A gene.

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Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B is an enzyme that in humans is encoded by the PDE1B gene.

<span class="mw-page-title-main">PDE8B</span> Protein-coding gene in the species Homo sapiens

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B is an enzyme that in humans is encoded by the PDE8B gene.

<span class="mw-page-title-main">PDE8A</span> Protein-coding gene in the species Homo sapiens

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene. Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.

<span class="mw-page-title-main">PDE6C</span> Protein-coding gene in the species Homo sapiens

Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' is an enzyme that in humans is encoded by the PDE6C gene.

<span class="mw-page-title-main">2',3'-Cyclic-nucleotide 3'-phosphodiesterase</span> Protein-coding gene in the species Homo sapiens

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000105650 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031842 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)".
  6. Zhang, HT (2009). "Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs". Current Pharmaceutical Design. 15 (14): 1688–1698. doi:10.2174/138161209788168092. PMID   19442182.

Further reading