PDS5B

PDS5B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5HDT
Identifiers
Aliases	PDS5B , APRIN, AS3, CG008, PDS5 cohesin associated factor B
External IDs	OMIM: 605333; MGI: 2140945; HomoloGene: 41001; GeneCards: PDS5B; OMA:PDS5B - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q13.1 Start 32,586,452 bp [1] End 32,778,019 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 G3 Start 150,597,204 bp [2] End 150,734,155 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve endothelial cell testicle epithelium of colon ventricular zone buccal mucosa cell tibia bone marrow cells oocyte Top expressed in superior cervical ganglion otolith organ utricle nucleus accumbens anterior amygdaloid area renal corpuscle olfactory tubercle vas deferens ventromedial nucleus paraventricular nucleus of hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding ATP binding DNA binding Cellular component chromosome cytosol chromatin chromosome, centromeric region nucleoplasm nucleus Biological process cell division cell cycle cell population proliferation regulation of cell population proliferation mitotic sister chromatid cohesion negative regulation of cell population proliferation DNA repair lens development in camera-type eye enteric nervous system development neuroblast migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23047 100710 Ensembl ENSG00000083642 ENSMUSG00000034021 UniProt Q9NTI5 Q4VA53 RefSeq (mRNA) NM_015032 NM_015928 NM_175310 NM_001346503 RefSeq (protein) NP_055847 NP_001333432 NP_780519 Location (UCSC) Chr 13: 32.59 – 32.78 Mb Chr 5: 150.6 – 150.73 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sister chromatid cohesion protein PDS5 homolog B(PDS5B) is a protein that in humans is encoded by the PDS5B gene. ^{[5] [6] [7]} It is a regulatory subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. The core cohesin complex is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. PDS5 associates with WAPL to stimulate the release of cohesin from DNA but during DNA replication PDS5 promotes acetylation of SMC3 by ESCO1 and ESCO2.

References

1. GRCh38: Ensembl release 89: ENSG00000083642 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034021 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Couch FJ, Rommens JM, Neuhausen SL, Belanger C, Dumont M, Abel K, Bell R, Berry S, Bogden R, Cannon-Albright L, Farid L, Frye C, Hattier T, Janecki T, Jiang P, Kehrer R, Leblanc JF, McArthur-Morrison J, Meney D, Miki Y, Peng Y, Samson C, Schroeder M, Snyder SC, Simard J, et al. (Feb 1997). "Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13". Genomics. 36 (1): 86–99. doi: 10.1006/geno.1996.0428 . PMID   8812419.
6. Geck P, Szelei J, Jimenez J, Sonnenschein C, Soto AM (May 1999). "Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus". J Steroid Biochem Mol Biol. 68 (1–2): 41–50. doi:10.1016/S0960-0760(98)00165-4. PMID   10215036. S2CID   32542980.
7. "Entrez Gene: APRIN androgen-induced proliferation inhibitor".