PDZD2

PDZD2
Identifiers
Aliases	PDZD2 , AIPC, PAPIN, PDZK3, PIN1, PDZ domain containing 2
External IDs	OMIM: 610697 MGI: 1922394 HomoloGene: 23393 GeneCards: PDZD2
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5p13.3 Start 31,639,131 bp [1] End 32,110,932 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 A1 Start 12,359,797 bp [2] End 12,740,010 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trigeminal ganglion spinal ganglia postcentral gyrus external globus pallidus placenta sural nerve orbitofrontal cortex right ventricle retinal pigment epithelium lower lobe of lung Top expressed in olfactory tubercle right lung right lung lobe left lung lobe skin of back ascending aorta globus pallidus superior colliculus nucleus accumbens hand More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 23037 68070 Ensembl ENSG00000133401 ENSMUSG00000022197 UniProt O15018 n/a RefSeq (mRNA) NM_015022 NM_178140 NM_001081064 RefSeq (protein) NP_835260 n/a Location (UCSC) Chr 5: 31.64 – 32.11 Mb Chr 15: 12.36 – 12.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

PDZ domain-containing protein 2 is a protein that in humans is encoded by the PDZD2 gene. ^{[5] [6]}

Function

Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. ^[6]

Interactions

PDZD2 has been shown to interact with PKP4. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000133401 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022197 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (September 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi: 10.1093/dnares/4.2.141 . PMID   9205841.
6. "Entrez Gene: PDZD2 PDZ domain containing 2".
7. Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (September 2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. 275 (38): 29875–80. doi: 10.1074/jbc.M005384200 . PMID   10896674.
8. Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (October 2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene. 21 (46): 7042–9. doi: 10.1038/sj.onc.1205852 . PMID   12370826.

Further reading

• Lindahl P, Abrahamson M, Björk I (1992). "Interaction of recombinant human cystatin C with the cysteine proteinases papain and actinidin". Biochem. J. 281 ( Pt 1) (Pt 1): 49–55. doi:10.1042/bj2810049. PMC   1130639 . PMID   1731767.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. 275 (38): 29875–80. doi: 10.1074/jbc.M005384200 . PMID   10896674.
• Chaib H, Rubin MA, Mucci NR, Li L, Day ML, Rhim JS, Macoska JA (2001). "Activated in prostate cancer: a PDZ domain-containing protein highly expressed in human primary prostate tumors". Cancer Res. 61 (6): 2390–4. PMID   11289102.
• Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene. 21 (46): 7042–9. doi: 10.1038/sj.onc.1205852 . PMID   12370826.
• Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC   187542 . PMID   12421765.
• Yeung ML, Tam TS, Tsang AC, Yao KM (2003). "Proteolytic cleavage of PDZD2 generates a secreted peptide containing two PDZ domains". EMBO Rep. 4 (4): 412–8. doi:10.1038/sj.embor.embor804. PMC   1319160 . PMID   12671685.
• Ma RY, Tam TS, Suen AP, Yeung PM, Tsang SW, Chung SK, Thomas MK, Leung PS, Yao KM (2006). "Secreted PDZD2 exerts concentration-dependent effects on the proliferation of INS-1E cells". Int. J. Biochem. Cell Biol. 38 (5–6): 1015–22. doi:10.1016/j.biocel.2005.11.012. PMID   16413998.