PELI2

PELI2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EGA, 3EGB
Identifiers
Aliases	PELI2 , pellino E3 ubiquitin protein ligase family member 2
External IDs	OMIM: 614798; MGI: 1891445; HomoloGene: 41431; GeneCards: PELI2; OMA:PELI2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q22.3 Start 56,117,814 bp [1] End 56,301,524 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 C1|14 24.6 cM Start 48,358,280 bp [2] End 48,519,032 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone testicle ganglionic eminence Achilles tendon jejunal mucosa monocyte body of pancreas metanephric glomerulus blood sural nerve Top expressed in basilar part of occipital bone spermatid fibula splanchnocranium seminiferous tubule spermatocyte Meckel's cartilage sciatic nerve ascending aorta aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin-ubiquitin ligase activity protein serine/threonine kinase activity transferase activity ubiquitin protein ligase activity Cellular component cytosol Biological process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of protein phosphorylation protein ubiquitination positive regulation of MAPK cascade protein polyubiquitination protein phosphorylation immune response Toll signaling pathway interleukin-1-mediated signaling pathway regulation of Toll signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57161 93834 Ensembl ENSG00000139946 ENSMUSG00000021846 UniProt Q9HAT8 Q8BST6 RefSeq (mRNA) NM_021255 NM_033602 RefSeq (protein) NP_067078 NP_291080 Location (UCSC) Chr 14: 56.12 – 56.3 Mb Chr 14: 48.36 – 48.52 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein pellino homolog 2 is a protein that in humans is encoded by the PELI2 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000139946 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021846 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Resch K, Jockusch H, Schmitt-John T (Apr 2001). "Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 172–4. doi:10.1159/000056895. PMID   11306823. S2CID   83911010.
6. Strelow A, Kollewe C, Wesche H (Jul 2003). "Characterization of Pellino2, a substrate of IRAK1 and IRAK4". FEBS Lett. 547 (1–3): 157–61. doi: 10.1016/S0014-5793(03)00697-5 . PMID   12860405.
7. "Entrez Gene: PELI2 pellino homolog 2 (Drosophila)".

Further reading

• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Liu Y, Dong W, Chen L, et al. (2004). "BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2". J. Biol. Chem. 279 (36): 37436–44. doi: 10.1074/jbc.M400241200 . PMID   15213237.
• Jensen LE, Whitehead AS (2003). "Pellino2 activates the mitogen activated protein kinase pathway". FEBS Lett. 545 (2–3): 199–202. doi: 10.1016/S0014-5793(03)00533-7 . PMID   12804775.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yu KY, Kwon HJ, Norman DA, et al. (2002). "Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling". J. Immunol. 169 (8): 4075–8. doi: 10.4049/jimmunol.169.8.4075 . PMID   12370331.