PELO

This article is about the protein. For people with the surname, see Pelo.

PELO
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X52
Identifiers
Aliases	PELO , PRO1770, CGI-17, pelota homolog (Drosophila), pelota mRNA surveillance and ribosome rescue factor
External IDs	OMIM: 605757 MGI: 2145154 HomoloGene: 6835 GeneCards: PELO
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q11.2 Start 52,787,916 bp [1] End 52,804,044 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 D2.2 Start 115,224,891 bp [2] End 115,226,722 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava saphenous vein Left adrenal gland stromal cell of endometrium oocyte popliteal artery left coronary artery right coronary artery islet of Langerhans thoracic aorta Top expressed in urethra bone marrow vagina yolk sac epithelium of urethra placenta ejaculatory duct urinary bladder prostate kidney More reference expression data BioGPS n/a
Gene ontology Molecular function endonuclease activity nuclease activity hydrolase activity metal ion binding protein binding ribosome binding Cellular component nucleus cytoplasm Biological process cell cycle RNA surveillance cell population proliferation nuclear-transcribed mRNA catabolic process, non-stop decay chromosome organization nucleic acid phosphodiester bond hydrolysis cell division protein biosynthesis endoderm development stem cell population maintenance positive regulation of BMP signaling pathway ribosome disassembly mesenchymal to epithelial transition nonfunctional rRNA decay nuclear-transcribed mRNA catabolic process, no-go decay inner cell mass cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53918 105083 Ensembl ENSG00000152684 ENSMUSG00000042275 UniProt Q9BRX2 Q80X73 RefSeq (mRNA) NM_015946 NM_134058 RefSeq (protein) NP_057030 NP_598819 Location (UCSC) Chr 5: 52.79 – 52.8 Mb Chr 13: 115.22 – 115.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein pelota homolog is a protein that in humans is encoded by the PELO gene. ^{[5] [6]}

This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. ^[6] In yeasts, the Dom34-Hbs1 complex (with ABCE1) that it forms is responsible for reactivating ribosomes and for recovering those stuck on mRNAs. ^[7] It is a paralog of the release factor eRF1.

The Drosophila homolog was first discovered in 1993. Mutants exhibit G2/M arrest in meiosis and large nebenkern form in late spermatocytes. ^[8] Human, yeast (Dom34), plant, and worm homologs are reported in 1995, ^[9] followed by one found in archaea. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000152684 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042275 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shamsadin R, Adham IM, von Beust G, Engel W (Nov 2000). "Molecular cloning, expression and chromosome location of the human pelota gene PELO". Cytogenetics and Cell Genetics. 90 (1–2): 75–8. doi:10.1159/000015667. PMID   11060452. S2CID   35316587.
6. "Entrez Gene: PELO pelota homolog (Drosophila)".
7. van den Elzen AM, Schuller A, Green R, Séraphin B (February 2014). "Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress". The EMBO Journal. 33 (3): 265–76. doi:10.1002/embj.201386123. PMC   3989619 . PMID   24424461.
8. Castrillon DH, Gönczy P, Alexander S, Rawson R, Eberhart CG, Viswanathan S, et al. (October 1993). "Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis". Genetics. 135 (2): 489–505. doi:10.1093/genetics/135.2.489. PMC   1205651 . PMID   8244010.
9. Eberhart CG, Wasserman SA (October 1995). "The pelota locus encodes a protein required for meiotic cell division: an analysis of G2/M arrest in Drosophila spermatogenesis". Development. 121 (10): 3477–86. doi:10.1242/dev.121.10.3477. PMID   7588080.
10. Ragan MA, Logsdon JM, Sensen CW, Charlebois RL, Doolittle WF (November 1996). "An archaebacterial homolog of pelota, a meiotic cell division protein in eukaryotes". FEMS Microbiology Letters. 144 (2–3): 151–5. doi: 10.1111/j.1574-6968.1996.tb08522.x . PMID   8900058.

Further reading

• Cheli Y, Kanaji S, Jacquelin B, Chang M, Nugent DJ, Kunicki TJ (2007). "Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1769 (9–10): 546–58. doi:10.1016/j.bbaexp.2007.06.004. PMC   2682338 . PMID   17669516.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC   310876 . PMID   10810093.