PEX11A

PEX11A
Identifiers
Aliases	PEX11A , PEX11-ALPHA, PMP28, hsPEX11p, peroxisomal biogenesis factor 11 alpha, PEX11alpha
External IDs	OMIM: 603866 MGI: 1338788 HomoloGene: 20829 GeneCards: PEX11A
Gene location (Human)
Chr.	Chromosome 15 (human)
End	89,690,783 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	79,392,879 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; germinal epithelium; ; parotid gland; ; adipose tissue; ; right lobe of liver; ; palpebral conjunctiva; ; subcutaneous adipose tissue; ; parietal pleura; ; secondary oocyte; ; abdominal fat;
	Top expressed in
	salivary gland; ; lacrimal gland; ; brown adipose tissue; ; parotid gland; ; left lobe of liver; ; submandibular gland; ; Paneth cell; ; proximal tubule; ; kidney; ; white adipose tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; protein homodimerization activity ;
Cellular component	integral component of membrane ; peroxisomal membrane ; peroxisome ; membrane ; integral component of peroxisomal membrane ; protein-containing complex ;
Biological process	regulation of peroxisome size ; peroxisome membrane biogenesis ; peroxisome organization ; signal transduction ; peroxisome fission ; brown fat cell differentiation ; regulation of lipid metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	8800
	18631
	ENSG00000166821
	ENSMUSG00000030545
	O75192
	Q9Z211
	NM_003847 ; NM_001271572 ; NM_001271573
	NM_011068
	NP_001258501 ; NP_001258502 ; NP_003838
	NP_035198
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 26, 2022

Peroxisomal membrane protein 11A is a protein that in humans is encoded by the PEX11A gene.^[5]^[6]

Related Research Articles

<span class="mw-page-title-main">Peroxisome</span> Type of organelle

A peroxisome (IPA: [pɛɜˈɹɒksɪˌsoʊm]) is a membrane-bound organelle, a type of microbody, found in the cytoplasm of virtually all eukaryotic cells. Peroxisomes are oxidative organelles. Frequently, molecular oxygen serves as a co-substrate, from which hydrogen peroxide (H₂O₂) is then formed. Peroxisomes owe their name to hydrogen peroxide generating and scavenging activities. They perform key roles in lipid metabolism and the conversion of reactive oxygen species. Peroxisomes are involved in the catabolism of very long chain fatty acids, branched chain fatty acids, bile acid intermediates (in the liver), D-amino acids, and polyamines, the reduction of reactive oxygen species – specifically hydrogen peroxide – and the biosynthesis of plasmalogens, i.e., ether phospholipids critical for the normal function of mammalian brains and lungs. They also contain approximately 10% of the total activity of two enzymes (Glucose-6-phosphate dehydrogenase and 6-Phosphogluconate dehydrogenase) in the pentose phosphate pathway, which is important for energy metabolism. It is vigorously debated whether peroxisomes are involved in isoprenoid and cholesterol synthesis in animals. Other known peroxisomal functions include the glyoxylate cycle in germinating seeds ("glyoxysomes"), photorespiration in leaves, glycolysis in trypanosomes ("glycosomes"), and methanol and/or amine oxidation and assimilation in some yeasts.

Peroxisomal targeting signal 1 receptor (PTS1R) is a protein that in humans is encoded by the PEX5 gene.

Peroxisome biogenesis factor 1, also known as PEX1, is a protein which in humans is encoded by the PEX1 gene.

Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the PEX19 gene.

Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.

ATP-binding cassette sub-family D member 3 is a protein that in humans is encoded by the ABCD3 gene.

Peroxisomal biogenesis factor 2 is a protein that in humans is encoded by the PEX2 gene.

Peroxisome assembly protein 12 is a protein that in humans is encoded by the PEX12 gene.

Peroxisomal membrane protein PEX13 is a protein that in humans is encoded by the PEX13 gene. It located on chromosome 2 next to KIAA1841

NSFL1 cofactor p47 is a protein that in humans is encoded by the NSFL1C gene.

Peroxisomal biogenesis factor 3 is a protein that in humans is encoded by the PEX3 gene.

Clathrin interactor 1 (CLINT1), also known as EPSIN4, is a protein which in humans is encoded by the CLINT1 gene.

Peroxisome biogenesis factor 10 is a protein that in humans is encoded by the PEX10 gene. Alternative splicing results in two transcript variants encoding different isoforms.

Peroxisomal membrane protein PMP34 is a protein that in humans is encoded by the SLC25A17 gene.

ATP-binding cassette sub-family D member 2 is a membrane pump/transporter protein that in humans is encoded by the ABCD2 gene.

Peroxisomal membrane protein PEX16 is a protein that in humans is encoded by the PEX16 gene.

Peroxisomal membrane protein 11B is a protein that in humans is encoded by the PEX11B gene. It is involved in the regulation of peroxisome abundance.

Derlin-3 is a protein that in humans is encoded by the DERL3 gene.

Rab9 effector protein with Kelch motifs also known as p40 is a protein that in humans is encoded by the RABEPK gene.

Peroxisomal membrane protein 4 is a protein that in humans is encoded by the PXMP4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166821 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030545 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA, Gould SJ (Dec 1998). "Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli". J Biol Chem. 273 (45): 29607–14. doi: 10.1074/jbc.273.45.29607 . PMID 9792670.
↑ "Entrez Gene: PEX11A peroxisomal biogenesis factor 11A".

Abe I, Okumoto K, Tamura S, Fujiki Y (1998). "Clofibrate-inducible, 28-kDa peroxisomal integral membrane protein is encoded by PEX11". FEBS Lett. 431 (3): 468–72. doi: 10.1016/S0014-5793(98)00815-1 . PMID 9714566.
South ST, Gould SJ (1999). "Peroxisome Synthesis in the Absence of Preexisting Peroxisomes". J. Cell Biol. 144 (2): 255–66. doi:10.1083/jcb.144.2.255. PMC 2132891 . PMID 9922452.
Sacksteder KA, Jones JM, South ST, et al. (2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547 . PMID 10704444.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Shimizu M, Akter MH, Emi Y, et al. (2007). "Peroxisome proliferator-activated receptor subtypes differentially cooperate with other transcription factors in selective transactivation of the perilipin/PEX11 alpha gene pair". J. Biochem. 139 (3): 563–73. doi:10.1093/jb/mvj053. PMID 16567422.
Orth T, Reumann S, Zhang X, et al. (2007). "The PEROXIN11 Protein Family Controls Peroxisome Proliferation in Arabidopsis". Plant Cell. 19 (1): 333–50. doi:10.1105/tpc.106.045831. PMC 1820951 . PMID 17220199.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166821 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030545 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9792670-5] Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA, Gould SJ (Dec 1998). "Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli". J Biol Chem. 273 (45): 29607–14. doi: 10.1074/jbc.273.45.29607 . PMID 9792670.

[entrez-6] "Entrez Gene: PEX11A peroxisomal biogenesis factor 11A".

[1]

[2]

[3]

[4]

[5]

[6]

PEX11A

Related Research Articles

References

Further reading