PFDN1

PFDN1
Identifiers
Aliases	PFDN1 , PDF, PFD1, prefoldin subunit 1
External IDs	OMIM: 604897 MGI: 1914449 HomoloGene: 37644 GeneCards: PFDN1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	140,303,113 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	36,587,577 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; islet of Langerhans; ; prefrontal cortex; ; cingulate gyrus; ; left ventricle; ; Brodmann area 9; ; amygdala; ; smooth muscle tissue; ; nucleus accumbens;
	Top expressed in
	ventromedial nucleus; ; mammillary body; ; lateral hypothalamus; ; facial motor nucleus; ; external carotid artery; ; maxillary prominence; ; lateral geniculate nucleus; ; arcuate nucleus; ; internal carotid artery; ; medial vestibular nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity ; unfolded protein binding ; protein folding chaperone activity ;
Cellular component	prefoldin complex ; cytoplasm ;
Biological process	regulation of transcription, DNA-templated ; protein folding ; cytoskeleton organization ;
	Sources:Amigo / QuickGO
Orthologs
	5201
	67199
	ENSG00000113068
	ENSMUSG00000024346
	O60925
	Q9CWM4 ; Q9CQF7
	NM_002622
	NM_026027
	NP_002613
	NP_080303
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 28, 2023

Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.^[5]^[6]

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.^[6]

Related Research Articles

Prefoldin (GimC) is a superfamily of proteins used in protein folding complexes. It is classified as a heterohexameric molecular chaperone in both archaea and eukarya, including humans. A prefoldin molecule works as a transfer protein in conjunction with a molecule of chaperonin to form a chaperone complex and correctly fold other nascent proteins. One of prefoldin's main uses in eukarya is the formation of molecules of actin for use in the eukaryotic cytoskeleton.

T-complex protein 1 subunit alpha is a protein that in humans is encoded by the TCP1 gene.

Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

<span class="mw-page-title-main">CCT5 (gene)</span> Protein-coding gene in the species Homo sapiens

T-complex protein 1 subunit epsilon is a protein that in humans is encoded by the CCT5 gene.

T-complex protein 1 subunit theta is a protein that in humans is encoded by the CCT8 gene. The CCT8 protein is a component of the TRiC complex.

60S ribosomal protein L4 is a protein that in humans is encoded by the RPL4 gene.

Tubulin-specific chaperone E is a protein that in humans is encoded by the TBCE gene.

Prefoldin subunit 6 is a protein that in humans is encoded by the PFDN6 gene.

60S ribosomal protein L18a is a protein that in humans is encoded by the RPL18A gene.

Tubulin-specific chaperone D is a protein that in humans is encoded by the TBCD gene.

T-complex protein 1 subunit zeta is a protein that in humans is encoded by the CCT6A gene.

T-complex protein 1 subunit beta is a protein that in humans is encoded by the CCT2 gene.

Gamma-tubulin complex component 2 is a protein that in humans is encoded by the TUBGCP2 gene. It is part of the gamma-tubulin complex, which is required for microtubule nucleation at the centrosome.

Prefoldin subunit 5 is a protein that in humans is encoded by the PFDN5 gene.

Actin-related protein 2/3 complex subunit 1A is a protein that in humans is encoded by the ARPC1A gene.

Prefoldin subunit 2 is a protein that in humans is encoded by the PFDN2 gene.

Prefoldin subunit 4 is a protein that in humans is encoded by the PFDN4 gene.

Tubulin-specific chaperone A is a protein that in humans is encoded by the TBCA gene.

T-complex protein 1 subunit zeta-2 is a protein that in humans is encoded by the CCT6B gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000113068 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024346 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi: 10.1016/S0092-8674(00)81446-4 . PMID 9630229. S2CID 16011829.
1 2 "Entrez Gene: PFDN1 prefoldin subunit 1".

Hartl FU, Hayer-Hartl M (2002). "Molecular chaperones in the cytosol: from nascent chain to folded protein". Science. 295 (5561): 1852–8. Bibcode:2002Sci...295.1852H. doi:10.1126/science.1068408. PMID 11884745. S2CID 15037639.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Iijima M, Kano Y, Nohno T, Namba M (1996). "Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines". Acta Med. Okayama. 50 (2): 73–7. PMID 8744932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Horrigan SK, Bartoloni L, Speer MC, et al. (1999). "A radiation hybrid breakpoint map of the acute myeloid leukemia (AML) and limb-girdle muscular dystrophy 1A (LGMD1A) regions of chromosome 5q31 localizing 122 expressed sequences". Genomics. 57 (1): 24–35. doi:10.1006/geno.1999.5765. PMID 10191080.
Hansen WJ, Cowan NJ, Welch WJ (1999). "Prefoldin–Nascent Chain Complexes in the Folding of Cytoskeletal Proteins". J. Cell Biol. 145 (2): 265–77. doi:10.1083/jcb.145.2.265. PMC 2133115 . PMID 10209023.
Cowan NJ, Lewis SA (2002). "A chaperone with a hydrophilic surface". Nat. Struct. Biol. 6 (11): 990–1. doi:10.1038/14870. PMID 10542082. S2CID 22081346.
Munnia A, Schütz N, Romeike BF, et al. (2001). "Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor". Oncogene. 20 (35): 4853–63. doi:10.1038/sj.onc.1204650. PMID 11521196. S2CID 1636204.
Rommelaere H, De Neve M, Neirynck K, et al. (2001). "Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families". J. Biol. Chem. 276 (44): 41023–8. doi: 10.1074/jbc.M106591200 . PMID 11535601.
Martín-Benito J, Boskovic J, Gómez-Puertas P, et al. (2003). "Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT". EMBO J. 21 (23): 6377–86. doi:10.1093/emboj/cdf640. PMC 136944 . PMID 12456645.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Bruneel A, Labas V, Mailloux A, et al. (2004). "Proteomic study of human umbilical vein endothelial cells in culture". Proteomics. 3 (5): 714–23. doi:10.1002/pmic.200300409. PMID 12748950. S2CID 19895166.
Gstaiger M, Luke B, Hess D, et al. (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science. 302 (5648): 1208–12. Bibcode:2003Sci...302.1208G. doi:10.1126/science.1088401. PMID 14615539. S2CID 26836888.
Simons CT, Staes A, Rommelaere H, et al. (2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". J. Biol. Chem. 279 (6): 4196–203. doi: 10.1074/jbc.M306053200 . PMID 14634002.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000113068 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024346 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9630229-5] Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi: 10.1016/S0092-8674(00)81446-4 . PMID 9630229. S2CID 16011829.

[entrez-6] 1 2 "Entrez Gene: PFDN1 prefoldin subunit 1".

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PFDN1

Related Research Articles

References

Further reading