PFDN1

PFDN1
Identifiers
Aliases	PFDN1 , PDF, PFD1, prefoldin subunit 1
External IDs	OMIM: 604897; MGI: 1914449; HomoloGene: 37644; GeneCards: PFDN1; OMA:PFDN1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q31.3 Start 140,245,035 bp [1] End 140,303,113 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 B2 Start 36,536,729 bp [2] End 36,587,577 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence ventricular zone muscle of thigh islet of Langerhans gonad prefrontal cortex C1 segment apex of heart right frontal lobe Top expressed in ventromedial nucleus mammillary body lateral hypothalamus lateral septal nucleus facial motor nucleus external carotid artery maxillary prominence anterior amygdaloid area lateral geniculate nucleus arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity unfolded protein binding protein folding chaperone activity Cellular component prefoldin complex cytoplasm Biological process regulation of transcription, DNA-templated protein folding cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5201 67199 Ensembl ENSG00000113068 ENSMUSG00000024346 UniProt O60925 Q9CWM4 Q9CQF7 RefSeq (mRNA) NM_002622 NM_026027 RefSeq (protein) NP_002613 NP_080303 Location (UCSC) Chr 5: 140.25 – 140.3 Mb Chr 18: 36.54 – 36.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene. ^{[5] [6]}

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled coils. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000113068 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024346 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi: 10.1016/S0092-8674(00)81446-4 . PMID   9630229. S2CID   16011829.
6. "Entrez Gene: PFDN1 prefoldin subunit 1".

Further reading

• Hartl FU, Hayer-Hartl M (2002). "Molecular chaperones in the cytosol: from nascent chain to folded protein". Science. 295 (5561): 1852–8. Bibcode:2002Sci...295.1852H. doi:10.1126/science.1068408. PMID   11884745. S2CID   15037639.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Iijima M, Kano Y, Nohno T, Namba M (1996). "Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines". Acta Med. Okayama. 50 (2): 73–7. PMID   8744932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Horrigan SK, Bartoloni L, Speer MC, et al. (1999). "A radiation hybrid breakpoint map of the acute myeloid leukemia (AML) and limb-girdle muscular dystrophy 1A (LGMD1A) regions of chromosome 5q31 localizing 122 expressed sequences". Genomics. 57 (1): 24–35. doi:10.1006/geno.1999.5765. PMID   10191080.
• Hansen WJ, Cowan NJ, Welch WJ (1999). "Prefoldin–Nascent Chain Complexes in the Folding of Cytoskeletal Proteins". J. Cell Biol. 145 (2): 265–77. doi:10.1083/jcb.145.2.265. PMC   2133115 . PMID   10209023.
• Cowan NJ, Lewis SA (2002). "A chaperone with a hydrophilic surface". Nat. Struct. Biol. 6 (11): 990–1. doi:10.1038/14870. PMID   10542082. S2CID   22081346.
• Munnia A, Schütz N, Romeike BF, et al. (2001). "Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor". Oncogene. 20 (35): 4853–63. doi:10.1038/sj.onc.1204650. PMID   11521196. S2CID   1636204.
• Rommelaere H, De Neve M, Neirynck K, et al. (2001). "Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families". J. Biol. Chem. 276 (44): 41023–8. doi: 10.1074/jbc.M106591200 . PMID   11535601.
• Martín-Benito J, Boskovic J, Gómez-Puertas P, et al. (2003). "Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT". EMBO J. 21 (23): 6377–86. doi:10.1093/emboj/cdf640. PMC   136944 . PMID   12456645.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bruneel A, Labas V, Mailloux A, et al. (2004). "Proteomic study of human umbilical vein endothelial cells in culture". Proteomics. 3 (5): 714–23. doi:10.1002/pmic.200300409. PMID   12748950. S2CID   19895166.
• Gstaiger M, Luke B, Hess D, et al. (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science. 302 (5648): 1208–12. Bibcode:2003Sci...302.1208G. doi:10.1126/science.1088401. PMID   14615539. S2CID   26836888.
• Simons CT, Staes A, Rommelaere H, et al. (2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". J. Biol. Chem. 279 (6): 4196–203. doi: 10.1074/jbc.M306053200 . PMID   14634002.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.