PFDN2

PFDN2
Identifiers
Aliases	PFDN2 , PFD2, prefoldin subunit 2
External IDs	OMIM: 613466 MGI: 1276111 HomoloGene: 7887 GeneCards: PFDN2
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.3 Start 161,100,556 bp [1] End 161,118,055 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 H3|1 79.35 cM Start 171,173,238 bp [2] End 171,186,822 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary ganglionic eminence amygdala gastrocnemius muscle prefrontal cortex Brodmann area 9 hypothalamus putamen nucleus accumbens substantia nigra Top expressed in lateral hypothalamus paraventricular nucleus of hypothalamus medial vestibular nucleus ventromedial nucleus dorsomedial hypothalamic nucleus cingulate gyrus mammillary body supraoptic nucleus arcuate nucleus globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding protein folding chaperone activity protein binding Cellular component cytoplasm mitochondrion nucleus prefoldin complex cytosol Biological process positive regulation of cytoskeleton organization protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5202 18637 Ensembl ENSG00000143256 ENSMUSG00000006412 UniProt Q9UHV9 O70591 RefSeq (mRNA) NM_012394 NM_011070 NM_001360824 NM_001360825 RefSeq (protein) NP_036526 NP_035200 NP_001347753 NP_001347754 Location (UCSC) Chr 1: 161.1 – 161.12 Mb Chr 1: 171.17 – 171.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Prefoldin subunit 2 is a protein that in humans is encoded by the PFDN2 gene. ^{[5] [6]}

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000143256 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006412 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Eddleston J, Murdoch JN, Copp AJ, Stanier P (Apr 1999). "Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp)". Genomics. 56 (2): 149–59. doi:10.1006/geno.1998.5701. PMID   10051400.
6. "Entrez Gene: PFDN2 prefoldin subunit 2".

Further reading

• Vainberg IE, Lewis SA, Rommelaere H, et al. (1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi: 10.1016/S0092-8674(00)81446-4 . PMID   9630229. S2CID   16011829.
• Hansen WJ, Cowan NJ, Welch WJ (1999). "Prefoldin–Nascent Chain Complexes in the Folding of Cytoskeletal Proteins". J. Cell Biol. 145 (2): 265–77. doi:10.1083/jcb.145.2.265. PMC   2133115 . PMID   10209023.
• Cowan NJ, Lewis SA (2002). "A chaperone with a hydrophilic surface". Nat. Struct. Biol. 6 (11): 990–1. doi:10.1038/14870. PMID   10542082. S2CID   22081346.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gstaiger M, Luke B, Hess D, et al. (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science. 302 (5648): 1208–12. Bibcode:2003Sci...302.1208G. doi:10.1126/science.1088401. PMID   14615539. S2CID   26836888.
• Simons CT, Staes A, Rommelaere H, et al. (2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". J. Biol. Chem. 279 (6): 4196–203. doi: 10.1074/jbc.M306053200 . PMID   14634002.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.