PFDN4

Last updated
PFDN4
Identifiers
Aliases PFDN4 , C1, PFD4, prefoldin subunit 4
External IDs OMIM: 604898; MGI: 1923512; HomoloGene: 37645; GeneCards: PFDN4; OMA:PFDN4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002623

NM_001013369
NM_001110152
NM_001199902

RefSeq (protein)

NP_002614

n/a

Location (UCSC) Chr 20: 54.21 – 54.23 Mb Chr 2: 170.34 – 170.36 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Prefoldin subunit 4 is a protein that in humans is encoded by the PFDN4 gene. [5] [6] [7]

Contents

Function

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000101132 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052033 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (May 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi: 10.1016/s0092-8674(00)81446-4 . PMID   9630229. S2CID   16011829.
  6. Iijima M, Kano Y, Nohno T, Namba M (Apr 1996). "Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines". Acta Medica Okayama. 50 (2): 73–7. PMID   8744932.
  7. 1 2 Coraboeuf E, Deroubaix E, Hoerter J (May 1976). "Control of ionic permeabilities in normal and ischemic heart". Circulation Research. 38 (5 Suppl 1): I92–8. PMID   5203.

Further reading