PGPEP1

PGPEP1
Identifiers
Aliases	PGPEP1 , PAP-I, PGP, PGP-I, PGPI, Pcp, pyroglutamyl-peptidase I, PGI
External IDs	OMIM: 610694 MGI: 1913772 HomoloGene: 9793 GeneCards: PGPEP1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,369,950 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	70,660,388 bp
RNA expression pattern
	Top expressed in
	cardia; ; renal medulla; ; pylorus; ; inferior ganglion of vagus nerve; ; internal globus pallidus; ; external globus pallidus; ; vena cava; ; ventral tegmental area; ; subthalamic nucleus; ; pancreatic ductal cell;
	Top expressed in
	proximal tubule; ; kidney; ; neural tube; ; adrenal gland; ; yolk sac; ; jejunum; ; ileum; ; left lobe of liver; ; duodenum; ; internal carotid artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	peptidase activity ; cysteine-type peptidase activity ; hydrolase activity ; pyroglutamyl-peptidase activity ;
Cellular component	cytoplasm ; cytosol ;
Biological process	proteolysis ;
	Sources:Amigo / QuickGO
Orthologs
	54858
	66522
	ENSG00000130517
	ENSMUSG00000056204
	Q9NXJ5
	Q9ESW8
NM_001300927 ; NM_001308366 ; NM_017712 ; NM_001329471 ; NM_001329476 ;
	NM_001329477 ; NM_001329478
	NM_023217
NP_001287856 ; NP_001295295 ; NP_001316400 ; NP_001316405 ; NP_001316406 ;
	NP_001316407 ; NP_060182
	NP_075706
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 30, 2022

The PGPEP1 gene in humans encodes the enzyme Pyroglutamyl-peptidase I.^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000130517 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056204 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: PGPEP1 pyroglutamyl-peptidase I".

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Valdivia A, Irazusta J, Fernández D, et al. (2005). "Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia". Regul. Pept. 122 (2): 79–84. doi:10.1016/j.regpep.2004.05.005. PMID 15380924. S2CID 24844740.
Minderman H, O'Loughlin KL, Pendyala L, Baer MR (2004). "VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein". Clin. Cancer Res. 10 (5): 1826–34. doi: 10.1158/1078-0432.CCR-0914-3 . PMID 15014037.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Dando PM, Fortunato M, Strand GB, et al. (2003). "Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme". Protein Expr. Purif. 28 (1): 111–9. doi:10.1016/S1046-5928(02)00632-0. PMID 12651114.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gil J, Larrinaga G, Meana JJ, et al. (2002). "Regional and subcellular distribution of soluble aminopeptidase in the human and the rat brain: a comparative study". Neuropeptides. 35 (5–6): 276–84. doi:10.1054/npep.2001.0870. PMID 12030812. S2CID 39976173.
Charli JL, Mendez M, Vargas MA, et al. (1990). "Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices". Neuropeptides. 14 (3): 191–6. doi:10.1016/0143-4179(89)90044-9. PMID 2575716. S2CID 13735633.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000130517 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056204 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PGPEP1 pyroglutamyl-peptidase I".

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PGPEP1

Related Research Articles

References

Further reading