PHB2

PHB2
Identifiers
Aliases	PHB2 , BAP, BCAP37, Bap37, PNAS-141, REA, p22, hBAP, prohibitin 2, Prohibitin-2
External IDs	OMIM: 610704 MGI: 102520 HomoloGene: 5263 GeneCards: PHB2
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.31 Start 6,965,327 bp [1] End 6,970,780 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 F2|6 59.17 cM Start 124,689,299 bp [2] End 124,693,913 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vulva nipple vastus lateralis muscle triceps brachii muscle jejunal mucosa thymus human penis embryo body of tongue biceps brachii Top expressed in yolk sac lip esophagus morula superior frontal gyrus spermatocyte duodenum spermatid thymus stomach More reference expression data BioGPS n/a
Gene ontology Molecular function protein N-terminus binding amide binding protein C-terminus binding protein binding estrogen receptor binding sphingolipid binding Cellular component cytoplasm membrane nuclear matrix cell surface mitochondrial outer membrane mitochondrion extracellular exosome nucleus cell periphery mitochondrial inner membrane axon postsynaptic density protein-containing complex presynaptic active zone glutamatergic synapse GABA-ergic synapse Biological process regulation of transcription, DNA-templated mammary gland branching involved in thelarche protein stabilization regulation of branching involved in mammary gland duct morphogenesis mitochondrion organization negative regulation of mammary gland epithelial cell proliferation positive regulation of DNA-binding transcription factor activity positive regulation of exit from mitosis mammary gland alveolus development negative regulation of DNA-binding transcription factor activity transcription, DNA-templated sister chromatid cohesion positive regulation of cell cycle G1/S phase transition positive regulation of ERK1 and ERK2 cascade negative regulation of transcription, DNA-templated negative regulation of intracellular estrogen receptor signaling pathway regulation of complement activation mitochondrial calcium ion transmembrane transport response to wounding negative regulation of apoptotic process cellular response to retinoic acid cellular response to hypoxia protein import into nucleus regulation of cytochrome-c oxidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11331 12034 Ensembl ENSG00000215021 ENSMUSG00000004264 UniProt Q99623 O35129 RefSeq (mRNA) NM_001144831 NM_001267700 NM_007531 RefSeq (protein) NP_001138303 NP_001254629 NP_031557 Location (UCSC) Chr 12: 6.97 – 6.97 Mb Chr 6: 124.69 – 124.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Prohibitin-2 is a protein that in humans is encoded by the PHB2 gene. ^{[5] [6] [7]}

Interactions

PHB2 has been shown to interact with PTMA. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000215021 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004264 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Coates PJ, Nenutil R, McGregor A, Picksley SM, Crouch DH, Hall PA, Wright EG (Apr 2001). "Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence". Exp Cell Res. 265 (2): 262–73. doi:10.1006/excr.2001.5166. PMID   11302691.
6. Coates PJ, Jamieson DJ, Smart K, Prescott AR, Hall PA (Oct 1997). "The prohibitin family of mitochondrial proteins regulate replicative lifespan". Curr Biol. 7 (8): 607–10. Bibcode:1997CBio....7..607C. doi: 10.1016/S0960-9822(06)00261-2 . PMID   9259555. S2CID   7153605.
7. "Entrez Gene: PHB2 prohibitin 2".
8. Martini PG, Katzenellenbogen Benita S (Jun 2003). "Modulation of estrogen receptor activity by selective coregulators". J. Steroid Biochem. Mol. Biol. 85 (2–5): 117–22. doi:10.1016/S0960-0760(03)00207-3. ISSN   0960-0760. PMID   12943695. S2CID   32374864.

Further reading

• Martini PG, Katzenellenbogen BS (2003). "Modulation of estrogen receptor activity by selective coregulators". J. Steroid Biochem. Mol. Biol. 85 (2–5): 117–22. doi:10.1016/S0960-0760(03)00207-3. PMID   12943695. S2CID   32374864.
• Ansari-Lari MA, Muzny DM, Lu J, et al. (1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): 314–26. doi: 10.1101/gr.6.4.314 . PMID   8723724.
• Ansari-Lari MA, Shen Y, Muzny DM, et al. (1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. doi: 10.1101/gr.7.3.268 . PMID   9074930.
• Montano MM, Ekena K, Delage-Mourroux R, et al. (1999). "An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6947–52. Bibcode:1999PNAS...96.6947M. doi: 10.1073/pnas.96.12.6947 . PMC   22022 . PMID   10359819.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Martini PG, Delage-Mourroux R, Kraichely DM, Katzenellenbogen BS (2000). "Prothymosin Alpha Selectively Enhances Estrogen Receptor Transcriptional Activity by Interacting with a Repressor of Estrogen Receptor Activity". Mol. Cell. Biol. 20 (17): 6224–32. doi:10.1128/MCB.20.17.6224-6232.2000. PMC   86097 . PMID   10938099.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Kurtev V, Margueron R, Kroboth K, et al. (2004). "Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases". J. Biol. Chem. 279 (23): 24834–43. doi: 10.1074/jbc.M312300200 . PMID   15140878.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. Bibcode:2006Natur.440..346S. doi: 10.1038/nature04569 . PMID   16541075.
• Kasashima K, Ohta E, Kagawa Y, Endo H (2007). "Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2". J. Biol. Chem. 281 (47): 36401–10. doi: 10.1074/jbc.M605260200 . PMID   17008324.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Takata H, Matsunaga S, Morimoto A, et al. (2007). "PHB2 protects sister-chromatid cohesion in mitosis". Curr. Biol. 17 (15): 1356–61. Bibcode:2007CBio...17.1356T. doi: 10.1016/j.cub.2007.07.009 . PMID   17656096. S2CID   18987683.