PHD finger protein 7

PHF7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WEQ
Identifiers
Aliases	PHF7 , HSPC045, HSPC226, NYD-SP6, PHD finger protein 7
External IDs	MGI: 1919088 HomoloGene: 69217 GeneCards: PHF7
Gene location (Human)
Chr.	Chromosome 3 (human)
End	52,423,641 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	30,973,274 bp
RNA expression pattern
	Top expressed in
	sperm; ; sural nerve; ; Achilles tendon; ; rectum; ; transverse colon; ; gastric mucosa; ; body of pancreas; ; gastrocnemius muscle; ; oocyte; ; skin of abdomen;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; Paneth cell; ; internal carotid artery; ; fossa; ; external carotid artery; ; corneal stroma; ; condyle; ; secondary oocyte;
	More reference expression data
	n/a
Orthologs
	51533
	71838
	ENSG00000010318
	ENSMUSG00000021902
	Q9BWX1
	Q9DAG9
	NM_001278221 ; NM_016483 ; NM_173341 ; NM_001321126 ; NM_001321127 Contents Function ; References ; Further reading ;
	NM_027949 ; NM_001360624 ; NM_001360625
	NP_001265150 ; NP_001308055 ; NP_001308056 ; NP_057567
	NP_082225 ; NP_001347553 ; NP_001347554
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

PHD finger protein 7 is a protein that in humans is encoded by the PHF7 gene. ^[5]

Function

Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells.

The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene.

Related Research Articles

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Dual specificity testis-specific protein kinase 1 is an enzyme that in humans is encoded by the TESK1 gene.

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Sperm flagellar protein 2 is a protein that in humans is encoded by the SPEF2 gene.

Transcriptional repressor CTCFL also known as BORIS is a protein that in humans is encoded by the CTCFL gene.

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Dual specificity testis-specific protein kinase 2 is an enzyme that in humans is encoded by the TESK2 gene.

Testis-specific basic protein Y 2 also known as basic charge, Y-linked 2 is a protein that in humans is encoded by the BPY2 gene which resides on the Y chromosome.

Germ cell-less, spermatogenesis associated 1 is a protein that in humans is encoded by the GMCL1 gene.

Tripartite motif containing 69 is a protein that in humans is encoded by the TRIM69 gene.

PHD finger protein 2 is a protein that in humans is encoded by the PHF2 gene.

Zinc finger protein 444 is a protein that in humans is encoded by the ZNF444 gene.

Coiled-coil domain-containing protein 181 (CCDC181) is a protein that in human is encoded by C1orf114, which is located at the Chromosome 1 at 1q24.2. The accession is Q5T1D7. Researches have recently revealed that CCDC 181 is a microtubule-binding protein that interacts with murine Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia. The disruption of Hook1 may lead to inappropriate function of spermatogenesis. The dysfunction may be related to the abnormal head shape of sperm or distinctive structural changes in flagella in sperm, which can result in male infertility. An increased rate of my gene has found in the haploid phase of male cell during meiosis, thus it is believed to relate to sperm cell and aid in spermatogenesis.

TATA-box binding protein associated factor 7 like is a protein that in humans is encoded by the TAF7L gene.

Serine protease 55 is a protein that in humans is encoded by the PRSS55 gene.

MORC family CW-type zinc finger 1 is a protein that in humans is encoded by the MORC1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000010318 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021902 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: PHD finger protein 7" . Retrieved 2017-09-05.

PHD finger protein 7

Contents

Function

Related Research Articles

References

Further reading