PIGB

PIGB
Identifiers
Aliases	PIGB , GPI-MT-III, PIG-B, phosphatidylinositol glycan anchor biosynthesis class B, EIEE80, DEE80
External IDs	OMIM: 604122 MGI: 1891825 HomoloGene: 3570 GeneCards: PIGB
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q21.3 Start 55,318,960 bp [1] End 55,355,648 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 D Start 72,914,701 bp [2] End 72,947,660 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood Achilles tendon monocyte anterior pituitary left lobe of thyroid gland right lobe of thyroid gland body of pancreas gastric mucosa spleen right uterine tube Top expressed in ascending aorta aortic valve supraoptic nucleus superior frontal gyrus morula proximal tubule secondary oocyte lip yolk sac mirror More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity mannosyltransferase activity glycosyltransferase activity glycolipid mannosyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process GPI anchor biosynthetic process preassembly of GPI anchor in ER membrane mannosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9488 55981 Ensembl ENSG00000069943 ENSMUSG00000079469 UniProt Q92521 Q9JJQ0 RefSeq (mRNA) NM_004855 NM_018889 RefSeq (protein) NP_004846 NP_061377 Location (UCSC) Chr 15: 55.32 – 55.36 Mb Chr 9: 72.91 – 72.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GPI mannosyltransferase 3 is an enzyme that in humans is encoded by the PIGB gene. ^{[5] [6]}

This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000069943 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000079469 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Takahashi M, Inoue N, Ohishi K, Maeda Y, Nakamura N, Endo Y, Fujita T, Takeda J, Kinoshita T (Dec 1996). "PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor". EMBO J. 15 (16): 4254–61. doi:10.1002/j.1460-2075.1996.tb00800.x. PMC   452151 . PMID   8861954.
6. "Entrez Gene: PIGB phosphatidylinositol glycan anchor biosynthesis, class B".

Further reading

• Mohney RP, Knez JJ, Ravi L, et al. (1994). "Glycoinositol phospholipid anchor-defective K562 mutants with biochemical lesions distinct from those in Thy-1- murine lymphoma mutants". J. Biol. Chem. 269 (9): 6536–42. doi: 10.1016/S0021-9258(17)37405-7 . PMID   7907094.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Anikster Y, Huizing M, Anderson PD, et al. (2002). "Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A". Am. J. Hum. Genet. 71 (2): 407–14. doi:10.1086/341606. PMC   379173 . PMID   12058346.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.