PIK3R3

PIK3R3
Identifiers
Aliases	PIK3R3 , p55, p55-GAMMA, p55PIK, phosphoinositide-3-kinase regulatory subunit 3, PI3KR3
External IDs	OMIM: 606076; MGI: 109277; HomoloGene: 2690; GeneCards: PIK3R3; OMA:PIK3R3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p34.1 Start 46,040,140 bp [1] End 46,133,036 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D1 Start 116,078,815 bp [2] End 116,160,253 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis paraflocculus of cerebellum nasal epithelium lower lobe of lung right hemisphere of cerebellum mucosa of paranasal sinus right ventricle right lung testicle ganglionic eminence Top expressed in cerebellar vermis lobe of cerebellum zygote hand ganglionic eminence otic vesicle inferior colliculi suprachiasmatic nucleus pontine nuclei secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol 3-kinase regulator activity protein binding 1-phosphatidylinositol-3-kinase activity phosphotyrosine residue binding 1-phosphatidylinositol-3-kinase regulator activity Cellular component cytosol phosphatidylinositol 3-kinase complex Biological process regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol-3-phosphate biosynthetic process insulin receptor signaling pathway positive regulation of protein phosphorylation cell migration involved in sprouting angiogenesis positive regulation of gene expression protein kinase B signaling positive regulation of cell migration phosphatidylinositol phosphate biosynthetic process phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8503 18710 Ensembl ENSG00000117461 ENSMUSG00000028698 UniProt Q92569 Q64143 RefSeq (mRNA) NM_001114172 NM_001303428 NM_001303429 NM_001328648 NM_001328649 NM_001328650 NM_001328651 NM_001328652 NM_001328653 NM_001328654 NM_003629 NM_181585 NM_001355584 NM_001355585 NM_001355586 RefSeq (protein) NP_001107644 NP_001290357 NP_001290358 NP_001315577 NP_001315578 NP_001315579 NP_001315580 NP_001315581 NP_001315582 NP_001315583 NP_003620 NP_853616 NP_001342513 NP_001342514 NP_001342515 Location (UCSC) Chr 1: 46.04 – 46.13 Mb Chr 4: 116.08 – 116.16 Mb PubMed search [3] [4]
Wikidata
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Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme, which in humans is encoded by the PIK3R3 gene. ^{[5] [6]}

Interactions

PIK3R3 has been shown to interact with Insulin-like growth factor 1 receptor, ^[7] IRS1 ^{[7] [8]} and Retinoblastoma protein. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000117461 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028698 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dey BR, Furlanetto RW, Nissley SP (May 1998). "Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor". Gene. 209 (1–2): 175–83. doi: 10.1016/S0378-1119(98)00045-6 . PMID   9524259.
6. "Entrez Gene: PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)".
7. Mothe, I; Delahaye L; Filloux C; Pons S; White M F; Van Obberghen E (Dec 1997). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Mol. Endocrinol. 11 (13): 1911–23. doi: 10.1210/mend.11.13.0029 . ISSN   0888-8809. PMID   9415396.
8. Xia, X; Serrero G (Aug 1999). "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation". Biochem. J. 341 (3): 831–7. doi:10.1042/0264-6021:3410831. ISSN   0264-6021. PMC   1220424 . PMID   10417350.
9. Xia, Xianmin; Cheng Aiwu; Akinmade Damilola; Hamburger Anne W (Mar 2003). "The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest". Mol. Cell. Biol. 23 (5): 1717–25. doi:10.1128/MCB.23.5.1717-1725.2003. ISSN   0270-7306. PMC   151709 . PMID   12588990.

Further reading

• Pons S, Asano T, Glasheen E, et al. (1995). "The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase". Mol. Cell. Biol. 15 (8): 4453–65. doi:10.1128/MCB.15.8.4453. PMC   230685 . PMID   7542745.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Tuscano JM, Engel P, Tedder TF, et al. (1996). "Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22". Eur. J. Immunol. 26 (6): 1246–52. doi:10.1002/eji.1830260610. PMID   8647200. S2CID   29471624.
• Takahashi-Tezuka M, Hibi M, Fujitani Y, et al. (1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene. 14 (19): 2273–82. doi: 10.1038/sj.onc.1201071 . PMID   9178903.
• Mothe I, Delahaye L, Filloux C, et al. (1998). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Mol. Endocrinol. 11 (13): 1911–23. doi: 10.1210/mend.11.13.0029 . PMID   9415396.
• Xia X, Serrero G (1999). "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation". Biochem. J. 341 (3): 831–7. doi:10.1042/0264-6021:3410831. PMC   1220424 . PMID   10417350.
• Inukai K, Funaki M, Anai M, et al. (2001). "Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations". FEBS Lett. 490 (1–2): 32–8. doi: 10.1016/S0014-5793(01)02132-9 . PMID   11172806.
• Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. PMID   12470648.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Xia X, Cheng A, Akinmade D, Hamburger AW (2003). "The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest". Mol. Cell. Biol. 23 (5): 1717–25. doi:10.1128/MCB.23.5.1717-1725.2003. PMC   151709 . PMID   12588990.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Soroceanu L, Kharbanda S, Chen R, et al. (2007). "Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3466–71. Bibcode:2007PNAS..104.3466S. doi: 10.1073/pnas.0611271104 . PMC   1802005 . PMID   17360667.
• Kallin A, Johannessen LE, Cani PD, et al. (2007). "SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma". J. Lipid Res. 48 (7): 1628–36. doi: 10.1194/jlr.M700136-JLR200 . PMID   17452746.