PIP4K2B

PIP4K2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BO1, 3WZZ, 3X01, 3X02, 3X03, 3X04, 3X05, 3X06, 3X07, 3X08, 3X09, 3X0A, 3X0B, 3X0C Contents Interactions ; Structure ; References ; Further reading ;
Identifiers
Aliases	PIP4K2B , PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta, PIP5P4KB, phosphatidylinositol-5-phosphate 4-kinase type 2 beta
External IDs	OMIM: 603261 MGI: 1934234 HomoloGene: 2634 GeneCards: PIP4K2B
Gene location (Human)
Chr.	Chromosome 17 (human)
End	38,800,126 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	97,635,530 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Brodmann area 9; ; prefrontal cortex; ; cerebellar hemisphere; ; muscle of leg; ; Achilles tendon; ; gastrocnemius muscle; ; amygdala; ; stromal cell of endometrium; ; nucleus accumbens;
	Top expressed in
	internal carotid artery; ; superior frontal gyrus; ; external carotid artery; ; hand; ; gastrocnemius muscle; ; foot; ; facial motor nucleus; ; piriform cortex; ; knee joint; ; hippocampus proper;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; 1-phosphatidylinositol-4-phosphate 5-kinase activity ; kinase activity ; phosphatidylinositol phosphate kinase activity ; protein binding ; ATP binding ; 1-phosphatidylinositol-3-phosphate 4-kinase activity ; 1-phosphatidylinositol-5-phosphate 4-kinase activity ; protein homodimerization activity ;
Cellular component	cytoplasm ; cytosol ; endoplasmic reticulum membrane ; membrane ; plasma membrane ; autophagosome ; endoplasmic reticulum ; nucleus ; nucleoplasm ;
Biological process	phosphatidylinositol metabolic process ; positive regulation of autophagosome assembly ; phosphorylation ; cell surface receptor signaling pathway ; regulation of autophagy ; phosphatidylinositol biosynthetic process ; phosphatidylinositol phosphate biosynthetic process ; regulation of phosphatidylinositol 3-kinase signaling ; phospholipid metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	8396
	108083
	ENSG00000277292 ; ENSG00000276293
	ENSMUSG00000018547
	P78356
	Q80XI4
	NM_003559 ; NM_138687
	NM_054051
	NP_003550
	NP_473392
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 09, 2024

Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene.^[5]^[6]^[7]^[8]

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol 4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol 4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.^[8]

Interactions

PIP4K2B has been shown to interact with TNFRSF1A.^[5] In addition, PIP4K2B has been shown to interact with PIP4K2A and may modulate the cellular localisation of PIP4K2A.^[9]

Structure

The structure of PIP4K2B has been determined through X-ray crystallography.^[10]

Related Research Articles

<span class="mw-page-title-main">Phosphoinositide 3-kinase</span> Class of enzymes

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

<span class="mw-page-title-main">Phosphatidylinositol 4,5-bisphosphate</span> Chemical compound

Phosphatidylinositol 4,5-bisphosphate or PtdIns(4,5)P₂, also known simply as PIP₂ or PI(4,5)P₂, is a minor phospholipid component of cell membranes. PtdIns(4,5)P₂ is enriched at the plasma membrane where it is a substrate for a number of important signaling proteins. PIP2 also forms lipid clusters that sort proteins.

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.

Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene.

Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 is an enzyme that in humans is encoded by the PLCG2 gene.

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform is an enzyme that in humans is encoded by the PIK3CB gene.

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide is an enzyme that in humans is encoded by the PIK3C2A gene.

PIKfyve, a FYVE finger-containing phosphoinositide kinase, is an enzyme that in humans is encoded by the PIKFYVE gene.

Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.

Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma is an enzyme that in humans is encoded by the PIP5K1C gene.

Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha is an enzyme that in humans is encoded by the PIP4K2A gene.

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide is a protein that in humans is encoded by the DAPP1 gene.

Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha is an enzyme that in humans is encoded by the PIP5K1A gene.

Phosphatidylinositol 4-kinase 2-alpha is an enzyme that in humans is encoded by the PI4K2A gene.

Phosphatidylinositol-4-phosphate 5-kinase type-1 beta is an enzyme that in humans is encoded by the PIP5K1B gene.

Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.

Phosphatidylinositol 5-phosphate (PtdIns5P) is a phosphoinositide, one of the phosphorylated derivatives of phosphatidylinositol (PtdIns), that are well-established membrane-anchored regulatory molecules. Phosphoinositides participate in signaling events that control cytoskeletal dynamics, intracellular membrane trafficking, cell proliferation and many other cellular functions. Generally, phosphoinositides transduce signals by recruiting specific phosphoinositide-binding proteins to intracellular membranes.

Protein VAC14 homolog, also known as ArPIKfyve, is a protein that in humans is encoded by the VAC14 gene.

Phosphatidylinositol-4-phosphate 5-kinases are a class of enzymes that phosphorylate phosphatidylinositol 4-phosphate. They perform this reaction on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol 4,5-bisphosphate.

References

1 2 3 ENSG00000276293 GRCh38: Ensembl release 89: ENSG00000277292, ENSG00000276293 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018547 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV (Apr 1997). "A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase". J Biol Chem. 272 (9): 5861–70. doi: 10.1074/jbc.272.9.5861 . PMID 9038203.
↑ Luoh SW, Venkatesan N, Tripathi R (Feb 2004). "Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage". Oncogene. 23 (7): 1354–63. doi: 10.1038/sj.onc.1207251 . PMID 14691457.
↑ Rameh LE, Tolias KF, Duckworth BC, Cantley LC (Nov 1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192–6. Bibcode:1997Natur.390..192R. doi:10.1038/36621. PMID 9367159. S2CID 4403301.
1 2 "Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta".
↑ Bultsma Y, Keune WJ, Divecha N (2010-09-01). "PIP4Kβ interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kα" (PDF). Biochemical Journal. 430 (2): 223–235. doi:10.1042/bj20100341. ISSN 0264-6021. PMID 20583997.
↑ Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH (1998). "Structure of Type IIβ Phosphatidylinositol Phosphate Kinase". Cell. 94 (6): 829–839. doi: 10.1016/s0092-8674(00)81741-9 . PMID 9753329. S2CID 18221569.

Niiro H, Clark EA (2003). "Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1". Immunity. 19 (5): 637–40. doi: 10.1016/S1074-7613(03)00303-0 . PMID 14614850.
Carpenter CL (2004). "Btk-dependent regulation of phosphoinositide synthesis". Biochem. Soc. Trans. 32 (Pt 2): 326–9. doi:10.1042/BST0320326. PMID 15046600.
Rao VD, Misra S, Boronenkov IV, et al. (1998). "Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation". Cell. 94 (6): 829–39. doi: 10.1016/S0092-8674(00)81741-9 . PMID 9753329. S2CID 18221569.
Boronenkov IV, Loijens JC, Umeda M, Anderson RA (1999). "Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors". Mol. Biol. Cell. 9 (12): 3547–60. doi:10.1091/mbc.9.12.3547. PMC 25675 . PMID 9843587.
Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Res. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748 . PMID 12136098.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569. S2CID 13709685.
Richardson JP, Wang M, Clarke JH, et al. (2007). "Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation". Cell. Signal. 19 (6): 1309–14. doi:10.1016/j.cellsig.2007.01.010. PMC 1868964 . PMID 17303380.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000276293 GRCh38: Ensembl release 89: ENSG00000277292, ENSG00000276293 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018547 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9038203-5] 1 2 Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV (Apr 1997). "A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase". J Biol Chem. 272 (9): 5861–70. doi: 10.1074/jbc.272.9.5861 . PMID 9038203.

[pmid14691457-6] Luoh SW, Venkatesan N, Tripathi R (Feb 2004). "Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage". Oncogene. 23 (7): 1354–63. doi: 10.1038/sj.onc.1207251 . PMID 14691457.

[pmid9367159-7] Rameh LE, Tolias KF, Duckworth BC, Cantley LC (Nov 1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192–6. Bibcode:1997Natur.390..192R. doi:10.1038/36621. PMID 9367159. S2CID 4403301.

[entrez-8] 1 2 "Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta".

[9] Bultsma Y, Keune WJ, Divecha N (2010-09-01). "PIP4Kβ interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kα" (PDF). Biochemical Journal. 430 (2): 223–235. doi:10.1042/bj20100341. ISSN 0264-6021. PMID 20583997.

[10] Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH (1998). "Structure of Type IIβ Phosphatidylinositol Phosphate Kinase". Cell. 94 (6): 829–839. doi: 10.1016/s0092-8674(00)81741-9 . PMID 9753329. S2CID 18221569.

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PIP4K2B

Contents

Interactions

Structure

Related Research Articles

References

Further reading