PIP4K2B

PIP4K2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BO1, 3WZZ, 3X01, 3X02, 3X03, 3X04, 3X05, 3X06, 3X07, 3X08, 3X09, 3X0A, 3X0B, 3X0C
Identifiers
Aliases	PIP4K2B , PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta, PIP5P4KB, phosphatidylinositol-5-phosphate 4-kinase type 2 beta
External IDs	OMIM: 603261; MGI: 1934234; HomoloGene: 2634; GeneCards: PIP4K2B; OMA:PIP4K2B - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q12 Start 38,765,691 bp [1] End 38,800,126 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 D|11 61.07 cM Start 97,605,983 bp [2] End 97,635,530 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Brodmann area 9 right frontal lobe anterior cingulate cortex prefrontal cortex ventricular zone cerebellar hemisphere right hemisphere of cerebellum muscle of leg muscle of thigh Top expressed in dentate gyrus of hippocampal formation granule cell primary visual cortex muscle of thigh internal carotid artery superior frontal gyrus external carotid artery hand gastrocnemius muscle foot facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding 1-phosphatidylinositol-4-phosphate 5-kinase activity kinase activity phosphatidylinositol phosphate kinase activity protein binding ATP binding 1-phosphatidylinositol-3-phosphate 4-kinase activity 1-phosphatidylinositol-5-phosphate 4-kinase activity protein homodimerization activity Cellular component cytoplasm cytosol endoplasmic reticulum membrane membrane plasma membrane autophagosome endoplasmic reticulum nucleus nucleoplasm Biological process phosphatidylinositol metabolic process positive regulation of autophagosome assembly phosphorylation cell surface receptor signaling pathway regulation of autophagy phosphatidylinositol biosynthetic process phosphatidylinositol phosphate biosynthetic process regulation of phosphatidylinositol 3-kinase signaling phospholipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8396 108083 Ensembl ENSG00000277292 ENSG00000276293 ENSMUSG00000018547 UniProt P78356 Q80XI4 RefSeq (mRNA) NM_003559 NM_138687 NM_054051 RefSeq (protein) NP_003550 NP_473392 Location (UCSC) Chr 17: 38.77 – 38.8 Mb Chr 11: 97.61 – 97.64 Mb PubMed search [3] [4]
Wikidata
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Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene. ^{[5] [6] [7] [8]}

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol 4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol 4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. ^[8]

Interactions

PIP4K2B has been shown to interact with TNFRSF1A. ^[5] In addition, PIP4K2B has been shown to interact with PIP4K2A and may modulate the cellular localisation of PIP4K2A. ^[9]

Structure

The structure of PIP4K2B has been determined through X-ray crystallography. ^[10]

References

1. ENSG00000276293 GRCh38: Ensembl release 89: ENSG00000277292, ENSG00000276293 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018547 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV (Apr 1997). "A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase". J Biol Chem. 272 (9): 5861–70. doi: 10.1074/jbc.272.9.5861 . PMID   9038203.
6. Luoh SW, Venkatesan N, Tripathi R (Feb 2004). "Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage". Oncogene. 23 (7): 1354–63. doi: 10.1038/sj.onc.1207251 . PMID   14691457.
7. Rameh LE, Tolias KF, Duckworth BC, Cantley LC (Nov 1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192–6. Bibcode:1997Natur.390..192R. doi:10.1038/36621. PMID   9367159. S2CID   4403301.
8. "Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta".
9. Bultsma Y, Keune WJ, Divecha N (2010-09-01). "PIP4Kβ interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kα" (PDF). Biochemical Journal. 430 (2): 223–235. doi:10.1042/bj20100341. ISSN   0264-6021. PMID   20583997.
10. Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH (1998). "Structure of Type IIβ Phosphatidylinositol Phosphate Kinase". Cell. 94 (6): 829–839. doi: 10.1016/s0092-8674(00)81741-9 . PMID   9753329. S2CID   18221569.

Further reading

• Niiro H, Clark EA (2003). "Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1". Immunity. 19 (5): 637–40. doi: 10.1016/S1074-7613(03)00303-0 . PMID   14614850.
• Carpenter CL (2004). "Btk-dependent regulation of phosphoinositide synthesis". Biochem. Soc. Trans. 32 (Pt 2): 326–9. doi:10.1042/BST0320326. PMID   15046600.
• Rao VD, Misra S, Boronenkov IV, et al. (1998). "Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation". Cell. 94 (6): 829–39. doi: 10.1016/S0092-8674(00)81741-9 . PMID   9753329. S2CID   18221569.
• Boronenkov IV, Loijens JC, Umeda M, Anderson RA (1999). "Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors". Mol. Biol. Cell. 9 (12): 3547–60. doi:10.1091/mbc.9.12.3547. PMC   25675 . PMID   9843587.
• Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Res. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC   135748 . PMID   12136098.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Richardson JP, Wang M, Clarke JH, et al. (2007). "Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation". Cell. Signal. 19 (6): 1309–14. doi:10.1016/j.cellsig.2007.01.010. PMC   1868964 . PMID   17303380.