PKIB

PKIB
Identifiers
Aliases	PKIB , PRKACN2, protein kinase (cAMP-dependent, catalytic) inhibitor beta, cAMP-dependent protein kinase inhibitor beta
External IDs	OMIM: 606914 MGI: 101937 HomoloGene: 7474 GeneCards: PKIB
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q22.31 Start 122,471,917 bp [1] End 122,726,373 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 B4|10 29.22 cM Start 57,508,077 bp [2] End 57,617,208 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis cerebellar hemisphere rectum placenta bronchial epithelial cell pons islet of Langerhans jejunal mucosa pituitary gland anterior pituitary Top expressed in seminiferous tubule spermatid olfactory epithelium cerebellar vermis suprachiasmatic nucleus supraoptic nucleus carotid body pontine nuclei paraventricular nucleus of hypothalamus piriform cortex More reference expression data BioGPS n/a
Gene ontology Molecular function protein kinase inhibitor activity cAMP-dependent protein kinase inhibitor activity Cellular component cytoplasm nucleus Biological process positive regulation of telomere maintenance via telomerase positive regulation of telomere capping positive regulation of telomerase activity negative regulation of cAMP-dependent protein kinase activity negative regulation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5570 18768 Ensembl ENSG00000135549 ENSMUSG00000019876 UniProt Q9C010 Q04758 RefSeq (mRNA) NM_001270393 NM_001270394 NM_001270395 NM_032471 NM_181794 NM_181795 NM_001039050 NM_001039051 NM_001039052 NM_001039053 NM_001190402 NM_008863 RefSeq (protein) NP_001257322 NP_001257323 NP_001257324 NP_115860 NP_861459 NP_861460 n/a Location (UCSC) Chr 6: 122.47 – 122.73 Mb Chr 10: 57.51 – 57.62 Mb PubMed search [3] [4]
Wikidata
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cAMP-dependent protein kinase inhibitor beta is a protein that in humans is encoded by the PKIB gene. ^{[5] [6]}

The protein encoded by this gene is a member of the cAMP-dependent protein kinase inhibitor family. Studies of a similar protein in rat suggest that this protein may interact with the catalytic subunit of cAMP-dependent protein kinase and act as a competitive inhibitor. At least three alternatively spliced transcript variants encoding the same protein have been reported. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000135549 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019876 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA". Biochem J. 349 (Pt 2): 403–7. doi:10.1042/0264-6021:3490403. PMC   1221161 . PMID   10880337.
6. "Entrez Gene: PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi: 10.1038/nature02055 . PMID   14574404.
• Giangrande PH, Hallstrom TC, Tunyaplin C, et al. (2003). "Identification of E-Box Factor TFE3 as a Functional Partner for the E2F3 Transcription Factor". Mol. Cell. Biol. 23 (11): 3707–20. doi:10.1128/MCB.23.11.3707-3720.2003. PMC   155231 . PMID   12748276.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Qi ZY, Li Y, Ying K, et al. (2002). "Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes". J. Neurooncol. 56 (3): 197–208. doi:10.1023/A:1015079705841. PMID   12061725. S2CID   23878825.
• Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res. 99 (2): 145–9. doi:10.1016/S0169-328X(02)00104-3. PMID   11978406.
• Scarpetta MA, Uhler MD (1993). "Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse". J. Biol. Chem. 268 (15): 10927–31. doi: 10.1016/S0021-9258(18)82074-9 . PMID   7684369.
• Van Patten SM, Ng DC, Th'ng JP, et al. (1991). "Molecular cloning of a rat testis form of the inhibitor protein of cAMP-dependent protein kinase". Proc. Natl. Acad. Sci. U.S.A. 88 (12): 5383–7. Bibcode:1991PNAS...88.5383V. doi: 10.1073/pnas.88.12.5383 . PMC   51877 . PMID   2052616.