PLEK2

PLEK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X1G
Identifiers
Aliases	PLEK2 , pleckstrin 2
External IDs	OMIM: 608007 MGI: 1351466 HomoloGene: 8447 GeneCards: PLEK2
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q23.3-q24.1 Start 67,386,984 bp [1] End 67,412,167 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 C3 Start 78,935,465 bp [2] End 78,953,738 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte Left adrenal gland corpus epididymis rectum jejunal mucosa right lobe of thyroid gland duodenum left lobe of thyroid gland pancreatic epithelial cell Top expressed in Paneth cell molar gastric mucosa mucous cell of stomach Epithelium of stomach pyloric antrum duodenum lip intestinal villus left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-3,4-bisphosphate binding phosphatidylinositol-3,5-bisphosphate binding phosphatidylinositol-3-phosphate binding Cellular component cytoplasm plasma membrane cell projection lamellipodium membrane cytoskeleton membrane Biological process intracellular signal transduction actin cytoskeleton organization positive regulation of cell projection organization actin cytoskeleton reorganization positive regulation of plasma membrane bounded cell projection assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26499 27260 Ensembl ENSG00000100558 ENSMUSG00000021118 UniProt Q9NYT0 Q9WV52 RefSeq (mRNA) NM_016445 NM_013738 RefSeq (protein) NP_057529 NP_038766 Location (UCSC) Chr 14: 67.39 – 67.41 Mb Chr 12: 78.94 – 78.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene. ^{[5] [6] [7]} The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000100558 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021118 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lemmon, Mark A.; Ferguson, Kathryn M.; Abrams, Charles S. (2002). "Pleckstrin homology domains and the cytoskeleton". FEBS Letters. 513 (1): 71–76. doi: 10.1016/S0014-5793(01)03243-4 . PMID   11911883.
6. Hamaguchi N, Ihara S, Ohdaira T, Nagano H, Iwamatsu A, Tachikawa H, Fukui Y (Aug 2007). "Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading". Biochem Biophys Res Commun. 361 (2): 270–5. doi:10.1016/j.bbrc.2007.06.132. PMID   17658464.
7. "Entrez Gene: PLEK2 pleckstrin 2".
8. "AceView: PLEK2 gene". AceView. National Library of Medicine. Retrieved 24 April 2011.

Further reading

• Bach TL, Kerr WT, Wang Y, et al. (2007). "PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization". Blood. 109 (3): 1147–55. doi:10.1182/blood-2006-02-001339. PMC   1785144 . PMID   17008542.
• Inazu T, Kuroiwa A, Matsuda Y, Miyamoto K (2005). "Cloning, expression and chromosomal assignment of human pleckstrin 2". Mol. Biol. Rep. 32 (1): 35–40. doi:10.1007/s11033-004-4747-x. PMID   15865208. S2CID   8131790.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Inazu T, Yamada K, Miyamoto K (1999). "Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family". Biochem. Biophys. Res. Commun. 265 (1): 87–93. doi:10.1006/bbrc.1999.1461. PMID   10548495.
• Hu MH, Bauman EM, Roll RL, et al. (1999). "Pleckstrin 2, a widely expressed paralog of pleckstrin involved in actin rearrangement". J. Biol. Chem. 274 (31): 21515–8. doi: 10.1074/jbc.274.31.21515 . PMID   10419454.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.